{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:47:18Z","timestamp":1782215238437,"version":"3.54.5"},"reference-count":39,"publisher":"Termedia Sp. z.o.o.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Podoplanin (D2-40) is a\u00a0lymphatic endothelial marker that is considered as a\u00a0specific marker for lymphatic endothelial cells and lymphangiogenesis in salivary gland carcinomas (SGCs). Aim: the\u00a0present study aimed to investigate the\u00a0immunohistochemical expression of\u00a0podoplanin in SGCs and to correlate its expression with the\u00a0clinicopathological parameters and patients\u2019 survival. &lt;br \/&gt;\nForty-nine SGC cases were electronically selected. Demographic, clinical, laboratory, and survival data were reviewed and tabulated. Immunohistochemistry was performed using antipodoplanin. Cases were divided into low and high expression based on a\u00a0scoring system. A\u00a0score of\u00a00 and 1 was considered low expression, while &gt; 1 was considered high expression. &lt;br \/&gt;\nPodoplanin high expression was seen in 46.9% of\u00a0cases, and 53.1% of\u00a0cases showed low expression. Significant statistical associations were seen between podoplanin expression and tumour grade ( p \u2264 0.001), tumour-nodal- metastasis (TNM) stage (p \u2264 0.001), tumour size (p \u2264 0.001), nodal metastasis (p \u2264 0.001), tumour type  (p = 0.03), prognosis (p \u2264 0.001), and mortality (p \u2264 0.001). The overall survival and progression-free survival differed significantly in cases with high and low expression (p \u2264 0.001). &lt;br \/&gt;\nPodoplanin overexpression might be a\u00a0significant prognostic indicator for patients with SGCs, implicating that it is a\u00a0potential therapeutic target to improve survival in these cancer patients.<\/jats:p>","DOI":"10.5114\/pjp.2022.125820","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T05:57:30Z","timestamp":1679291850000},"page":"320-329","source":"Crossref","is-referenced-by-count":0,"title":["Podoplanin expression in salivary gland carcinomas and its clinical significance. An immunohistochemical study"],"prefix":"10.5114","volume":"73","author":[{"given":"Samar","family":"Soliman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud F","family":"Elsherbeny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Sheta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelaty Shawky","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha M","family":"Fawzy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa H.","family":"Sakr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Lotfy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"ref-1692581","doi-asserted-by":"crossref","unstructured":"Ansari MH. 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Angiogenesis and lymphangiogenesis in salivary gland adenoid cystic carcinoma and mucoepidermoid carcinoma. 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