{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:48:58Z","timestamp":1782215338875,"version":"3.54.5"},"reference-count":16,"publisher":"Termedia Sp. z.o.o.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>A\u00a0diffuse leptomeningeal glioneuronal tumours (DLGNT) are very rare tumours of\u00a0the\u00a0central nervous system, typically characterized by enhancement of\u00a0subarachnoid space with cystic lesions, diffuse leptomeningeal infiltration, and no primary mass. We report an atypical clinical presentation of\u00a0DLGNT. A\u00a048-year-old male was admitted to hospital with symptoms of\u00a0ischaemic stroke. Magnetic resonance imaging of\u00a0the\u00a0head revealed contrast enhancement of\u00a0the\u00a0meninges and other parts of\u00a0the\u00a0brain. A\u00a0stereotactic frame biopsy was performed on the\u00a0patient, which revealed the\u00a0DLGNT. Diffuse leptomeningeal glioneuronal tumours are mostly seen in individuals less than 18 years old and are characterized by slow growth and low-grade histological appearance. Diffuse leptomeningeal glioneuronal tumours can be aggressive in adults.<\/jats:p>","DOI":"10.5114\/pjp.2022.125822","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T05:57:30Z","timestamp":1679291850000},"page":"371-375","source":"Crossref","is-referenced-by-count":2,"title":["Atypical clinical presentation mimicking stroke in an adult patient caused by a rare diffuse leptomeningeal glioneuronal tumour"],"prefix":"10.5114","volume":"73","author":[{"given":"Angelika","family":"Stapi\u0144ska-Syniec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gogol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Acewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Sobstyl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Wierzba-Bobrowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wies\u0142awa","family":"Grajkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"ref-1692776","doi-asserted-by":"crossref","unstructured":"Wesseling P, Capper D. WHO 2016 classification of\u00a0gliomas.\u00a0Neuropathol Appl Neurobiol 2018; 44: 139-150.","DOI":"10.1111\/nan.12432"},{"key":"ref-1692777","doi-asserted-by":"crossref","unstructured":"Gardiman MP, Fassan M, Orvieto E, et al. Diffuse leptomeningeal glioneuronal tumors: a\u00a0new entity? Brain Pathol 2010; 20: 361-366.","DOI":"10.1111\/j.1750-3639.2009.00285.x"},{"key":"ref-1692778","doi-asserted-by":"crossref","unstructured":"Fiaschi P, Badaloni F, Cagetti B, et al. Disseminated oligodendroglial-like leptomeningeal tumor in the\u00a0adult: case report and review of\u00a0the\u00a0literature.\u00a0World Neurosurg 2018; 114: 53-57.","DOI":"10.1016\/j.wneu.2018.02.160"},{"key":"ref-1692779","doi-asserted-by":"crossref","unstructured":"Cho HJ, Myung JK, Kim H, et al. Primary diffuse leptomeningeal glioneuronal tumors.\u00a0Brain Tumor Pathol 2015; 32: 49-55.","DOI":"10.1007\/s10014-014-0187-z"},{"key":"ref-1692780","doi-asserted-by":"crossref","unstructured":"Louis DN, Perry A, Reifenberger G, et al. The 2016 World Health Organization Classification of\u00a0Tumors of\u00a0the\u00a0Central Nervous System: a\u00a0summary.\u00a0Acta Neuropathol 2016; 131: 803-820.","DOI":"10.1007\/s00401-016-1545-1"},{"key":"ref-1692781","doi-asserted-by":"crossref","unstructured":"Ghoniya R, Raheja A. Imaging in diffuse leptomeningeal glioneuronal tumor.\u00a0Neurol India 2019; 67: 615-616.","DOI":"10.4103\/0028-3886.258051"},{"key":"ref-1692782","doi-asserted-by":"crossref","unstructured":"Lakhani DA, Mankad K, Chhabda S, et al. Diffuse leptomeningeal glioneuronal tumor of\u00a0childhood.\u00a0 Am J Neuroradiol 2020; 41: 2155-2159.","DOI":"10.3174\/ajnr.A6737"},{"key":"ref-1692783","doi-asserted-by":"crossref","unstructured":"Tiwari S, Yadav T, Pamnani J, et al. Diffuse leptomeningeal glioneuronal tumor: a\u00a0unique leptomeningeal tumor entity.\u00a0World Neurosurg 2020; 135: 297-300.","DOI":"10.1016\/j.wneu.2019.12.119"},{"key":"ref-1692784","doi-asserted-by":"crossref","unstructured":"Aguilera D, Castellino RC, Janss A, et al. Clinical responses of\u00a0patients with diffuse leptomeningeal glioneuronal tumors to chemotherapy.\u00a0Childs Nerv Syst 2018; 34:29-334.","DOI":"10.1007\/s00381-017-3584-x"},{"key":"ref-1692785","doi-asserted-by":"crossref","unstructured":"Deng MY, Sill M, Chiang J, et al. Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features.\u00a0Acta Neuropathol 2018; 136: 239-253.","DOI":"10.1007\/s00401-018-1865-4"},{"key":"ref-1692786","doi-asserted-by":"crossref","unstructured":"Xu H, Chen F, Zhu H, Luo L, Zhang R. Diffuse leptomeningeal glioneuronal tumor in a\u00a0Chinese adult: a\u00a0novel case report and review of\u00a0literature.\u00a0Acta neurologica Belgica 2020;\u00a0120: 247-256.","DOI":"10.1007\/s13760-019-01262-9"},{"key":"ref-1692787","doi-asserted-by":"crossref","unstructured":"Kang JH, Buckley AF, Nagpal S, Fischbein N, Peters KB. A\u00a0diffuse leptomeningeal glioneuronal tumor without diffuse leptomeningeal involvement: detailed molecular and clinical characterization.\u00a0J Neuropathol Exp Neurol 2018; 77: 751-756.","DOI":"10.1093\/jnen\/nly053"},{"key":"ref-1692788","doi-asserted-by":"crossref","unstructured":"Tiwari N, Tamrazi B, Robison N, Krieger M, Ji J, Tian D. Unusual radiological and histological presentation of\u00a0a\u00a0diffuse leptomeningeal glioneuronal tumor (DLGNT) in a\u00a013-year-old girl.\u00a0Childs Nerv Syst 2019; 35: 1609-1614.","DOI":"10.1007\/s00381-019-04074-7"},{"key":"ref-1692789","doi-asserted-by":"crossref","unstructured":"Appay R, Pages M, Colin C, Jones DTW, Varlet P, Figarella- Branger D. Diffuse leptomeningeal glioneuronal tumor: a\u00a0double misnomer? A\u00a0report of\u00a0two cases.\u00a0Acta Neuropathol Commun 2020; 8: 95.","DOI":"10.1186\/s40478-020-00978-7"},{"key":"ref-1692790","doi-asserted-by":"crossref","unstructured":"Karlowee V, Kolakshyapati M, Amatya VJ, et al. Diffuse leptomeningeal glioneuronal tumor (DLGNT) mimicking Whipple\u2019s disease: a\u00a0case report and literature review.\u00a0Childs Nerv Syst 2017; 33: 1411-1414.","DOI":"10.1007\/s00381-017-3405-2"},{"key":"ref-1692791","doi-asserted-by":"crossref","unstructured":"Lee JK, Ko HC, Choi JG, Lee YS, Son BC. A\u00a0case of\u00a0diffuse leptomeningeal glioneuronal tumor misdiagnosed as chronic tuberculous meningitis without brain biopsy.\u00a0Case Rep Neurol Med 2018; 2018: 1391943.","DOI":"10.1155\/2018\/1391943"}],"container-title":["Polish Journal of Pathology"],"original-title":["Nietypowy przebieg kliniczny na\u015bladuj\u0105cy udar spowodowany rzadkim przypadkiem rozlanego leptomeningialnego glioneuronalnego guza u doros\u0142ego pacjenta. 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