{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:48:23Z","timestamp":1782215303074,"version":"3.54.5"},"reference-count":22,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Lobular capillary hemangioma, a\u00a0benign vascular tumor of\u00a0the\u00a0skin or mucous membranes characterized by rapid growth and a\u00a0friable surface, is widely but  inappropriately termed pyogenic granuloma (now considered a\u00a0misnomer by some  theories) due to lack of\u00a0evidence for infectious etiopathogenesis. Some studies promote the\u00a0theory of\u00a0a\u00a0hyperplastic, neovascular response to an angiogenic stimulus with imbalance of\u00a0promoters and inhibitors. &lt;br \/&gt;\nHere we present a\u00a0series of\u00a04 cases of\u00a0patients who visited the\u00a0Oral Medicine OPD with a\u00a0complaint of\u00a0similar painless malformations showing granulomatous and\/or fibrous tissue proliferation andwhich, after thorough history taking, clinical examination and excisional biopsy, were revealed to be lobular capillary hemangioma under histopathologic diagnosis. &lt;br \/&gt;\nThe following discussion revolves around the\u00a0fact that, even though such exophytic lesions may present with variable features, a\u00a0proper, accurate and logical diagnostic entity may be used to help in better coordination among the\u00a0oral physician, oral pathologist and oral surgeon in framing the\u00a0desired treatment plan.<\/jats:p>","DOI":"10.5114\/pjp.2023.127012","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T03:45:30Z","timestamp":1682567130000},"page":"51-55","source":"Crossref","is-referenced-by-count":1,"title":["In search of an appropriate clinical diagnostic term with indefinite etiology. A case series on lobular capillary hemangioma"],"prefix":"10.5114","volume":"74","author":[{"given":"Biswadip","family":"Shyam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandavi Shailesh","family":"Waghmare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasavi","family":"Santosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavika Sachin","family":"Vhatkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"ref-1692378","unstructured":"Sivapathasundharam B. Shafer\u2019s textbook of\u00a0oral pathology e-book. Elsevier Health Sciences 2016."},{"key":"ref-1692379","unstructured":"Glick M. Burket\u2019s oral medicine. PMPH USA 2015."},{"key":"ref-1692380","doi-asserted-by":"crossref","unstructured":"Chan C, Iv M, Fischbein N, Dahmoush H. Lobular capillary hemangioma of\u00a0the\u00a0mandible: a\u00a0case report. Clin Imaging 2018; 50: 246-249.","DOI":"10.1016\/j.clinimag.2018.04.012"},{"key":"ref-1692381","unstructured":"Available from: https:\/\/www.issva.org\/UserFiles\/file\/ISSVA-Classification-2018.pdf."},{"key":"ref-1692382","doi-asserted-by":"crossref","unstructured":"Kunimoto K, Yamamoto Y, Jinnin M. ISSVA classification of\u00a0vascular anomalies and molecular biology.\u00a0Int J Mol Sci\u00a02022;\u00a023: 2358.","DOI":"10.3390\/ijms23042358"},{"key":"ref-1692383","doi-asserted-by":"crossref","unstructured":"Rachappa MM, Triveni MN. Capillary hemangioma or pyogenic granuloma: a\u00a0diagnostic dilemma. Contemp Clin Dent 2010; 1: 119.","DOI":"10.4103\/0976-237X.68593"},{"key":"ref-1692384","doi-asserted-by":"crossref","unstructured":"Marla V, Shrestha A, Goel K, Shrestha S. The histopathological spectrum of\u00a0pyogenic granuloma: a\u00a0case series.\u00a0Case Rep Dent 2016; ID 1323798: 6.","DOI":"10.1155\/2016\/1323798"},{"key":"ref-1692385","doi-asserted-by":"crossref","unstructured":"Mills SE, Cooper PH, Fechner RE. Lobular capillary hemangioma: the\u00a0underlying lesion of\u00a0pyogenic granuloma. A\u00a0study of\u00a0 73 cases from the\u00a0oral and nasal mucous membranes. Am J Surg Pathol 1980; 4: 470-479.","DOI":"10.1097\/00000478-198010000-00007"},{"key":"ref-1692386","doi-asserted-by":"crossref","unstructured":"Manovijay B, Rajathi P, Fenn SM, Ekar B. Recurrent epulis granulomatosa: a\u00a0second look. J Adv Clin Res Insights 2015; 2: 140-142.","DOI":"10.15713\/ins.jcri.63"},{"key":"ref-1692387","doi-asserted-by":"crossref","unstructured":"Cai Y, Sun R, He KF, Zhao YF, Zhao JH. Sclerotherapy for the\u00a0recurrent granulomatous epulis with pingyangmycin. Med Oral Patol Oral Cir Bucal 2017; 22: e214-e8.","DOI":"10.4317\/medoral.21422"},{"key":"ref-1692388","unstructured":"Ghadimi S, Chiniforush N, Najafi M, Amiri S. Excision of\u00a0epulis granulomatosa with diode laser in 8 years old boy. J Lasers Med Sci 2015; 6: 92-95."},{"key":"ref-1692389","unstructured":"Jain A, Deepa D. Recurrence of\u00a0peripheral ossifying fibroma: a\u00a0case report.\u00a0People\u2019s J Sci Res\u00a02010; 3: 23-25.\u00a0."},{"key":"ref-1692390","unstructured":"Reddy GV, Reddy J, Ramlal G, Ambati M. Peripheral ossifying fibroma: report of\u00a0two unusual cases.\u00a0Indian J Stomatol\u00a02011; 2: 130-133."},{"key":"ref-1692391","doi-asserted-by":"crossref","unstructured":"Effiom OA, Adeyemo WL, Soyele OO. Focal reactive lesions of\u00a0the\u00a0Gingiva: an analysis of\u00a0314 cases at a\u00a0tertiary Health Institution in Nigeria.\u00a0Niger Med J\u00a02011; 52: 35-40.","DOI":"10.4103\/0300-1652.80074"},{"key":"ref-1692392","doi-asserted-by":"crossref","unstructured":"Chadwick BL, Crawford PJ, Aldred MJ. Massive giant cell epulis in a\u00a0child with familial cyclic neutropenia.\u00a0Br Dent J\u00a01989; 167: 279-281.","DOI":"10.1038\/sj.bdj.4806999"},{"key":"ref-1692393","doi-asserted-by":"crossref","unstructured":"Katsikeris N, Kakarantza-Angelopoulou E, Angelopoulos AP. Peripheral giant cell granuloma. Clinicopathologic study of\u00a0224 new cases and review of\u00a0956 reported cases.\u00a0Int J Oral Maxillofac Surg\u00a01988; 17: 94-99.","DOI":"10.1016\/S0901-5027(88)80158-9"},{"key":"ref-1692394","unstructured":"Giansanti JS, Waldron CA. Peripheral giant cell granuloma: review of\u00a0720 cases.\u00a0J Oral Surg\u00a01969; 27: 787-791.\u00a0."},{"key":"ref-1692395","unstructured":"Mastammanavar D, Hunasgi S, Koneru A, Vanishree M, Surekha R, Vardendra M. Aggressive pyogenic granuloma: a\u00a0case report. Int J Oral Maxillofac Pathol 2014; 5: 29-32."},{"key":"ref-1692396","doi-asserted-by":"crossref","unstructured":"Shenoy SS, Dinkar AD. Pyogenic granuloma associated with bone loss in an eight year old child: a\u00a0case report. J Indian Soc Pedodont Prev Dentist 2006; 24: 201-203.","DOI":"10.4103\/0970-4388.28078"},{"key":"ref-1692397","doi-asserted-by":"crossref","unstructured":"LeBoit PE, Berger TG, Egbert BM, Beckstead JH, Yen TS, Stoler MH. Bacillary angiomatosis. The histopathology and differential diagnosis of\u00a0a\u00a0pseudoneoplastic infection in patients with human immunodeficiency virus infection. Am  J Surg Pathol 1989; 13: 909-920.","DOI":"10.1097\/00000478-198911000-00001"},{"key":"ref-1692398","doi-asserted-by":"crossref","unstructured":"Farah CS, Balasubramaniam R, McCullough MJ (eds). Contemporary oral medicine: a\u00a0comprehensive approach to clinical practice. Springer International Publishing 2019.","DOI":"10.1007\/978-3-319-72303-7"},{"key":"ref-1692399","doi-asserted-by":"crossref","unstructured":"Kamal R, Dahiya P, Puri A. Oral pyogenic granuloma: various concepts of\u00a0etiopathogenesis. J Oral Maxillofac Pathol 2012; 16: 79-82.","DOI":"10.4103\/0973-029X.92978"}],"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-159194-136630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-159194-136630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:57:24Z","timestamp":1782212244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/In-search-of-an-appropriate-clinical-diagnostic-term-with-indefinite-etiology-A-case,159194,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,27]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"alternative-id":["159194"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2023.127012","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,27]]}}}