{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:47:44Z","timestamp":1782215264054,"version":"3.54.5"},"reference-count":21,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>It has been demonstrated in many studies that angiotensin-converting enzyme (ACE) insertion\/deletion (I\/D) polymorphism is related to Henoch-Schonlein purpura nephritis (HSPN) risk in children. However, this conclusion remains controversial.&lt;br \/&gt;\nIn this study, we systemically retrieved relevant studies in electronic databases such as PUBMED, CNKI, and EMBASE followed by calculation of\u00a0odds ratios (OR) with 95% confidence intervals (CI). In addition, meta-package in STATA version 12.0 was used. Angiotensin-converting enzyme I\/D polymorphism was related to HSPN susceptibility in children (D vs. I: OR 1.47, 95% CI: 1.13\u20131.93; DD vs. II: OR 2.29, 95% CI: 1.29\u20134.07; DI vs. II: OR 1.10, 95% CI: 0.82\u20131.48; dominant model: OR 1.44, 95% CI: 1.09\u20131.89; recessive model: OR 2.26, 95% CI: 1.67\u20133.06). &lt;br \/&gt;\nIn addition, subgroup analysis stratified according to ethnicity indicated a\u00a0significant relationship between this polymorphism and HSPN susceptibility among Asians and Caucasians. The\u00a0data extracted from HaploReg indicated that ACE I\/D polymorphism was not in linkage disequilibrium with other variants in the\u00a0ACE gene.&lt;br \/&gt;\nThe\u00a0research shows that ACE I\/D polymorphism is related to HSPN susceptibility in children.<\/jats:p>","DOI":"10.5114\/pjp.2023.127014","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T03:45:30Z","timestamp":1682567130000},"page":"29-35","source":"Crossref","is-referenced-by-count":1,"title":["Angiotensin-converting enzyme insertion\/deletion gene polymorphism and Henoch-Schonlein purpura nephritis risk in children: a\u00a0meta-analysis"],"prefix":"10.5114","volume":"74","author":[{"given":"Pan","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"ref-1692309","doi-asserted-by":"crossref","unstructured":"Saulsbury FT. 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QJM 2006; 99: 253-265.","DOI":"10.1093\/qjmed\/hcl034"},{"key":"ref-1692313","doi-asserted-by":"crossref","unstructured":"Van der Knaap\u00a0R,\u00a0Siemes C,\u00a0Coebergh JWW,\u00a0et al. Reninangiotensin system inhibitors, angiotensin I-converting enzyme gene insertion\/deletion polymorphism and cancer: the\u00a0Rotterdam Study. Cancer 2008; 112: 748-757.","DOI":"10.1002\/cncr.23215"},{"key":"ref-1692314","unstructured":"Bar\u00e1t E,\u00a0B\u00f6sz\u00f6rm\u00e9nyi-Nagy G,\u00a0Debreczeni LA. Serum angiotensin converting enzyme values in chronic obstructive pulmonary disease. Acta Physiol Hung 1987; 70: 337-342."},{"key":"ref-1692315","doi-asserted-by":"crossref","unstructured":"Castellon R,\u00a0Hamdi HK. Demystifying the\u00a0ACE polymorphism: from genetics to biology. Curr Pharm Des 2007; 13: 1191-1198.","DOI":"10.2174\/138161207780618902"},{"key":"ref-1692316","doi-asserted-by":"crossref","unstructured":"Rigat B,\u00a0Hubert C,\u00a0Alhenc-Gelas F,\u00a0et al. 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Angiotensin-converting enzyme insertion\/deletion polymorphism and susceptibility to Kawasaki disease: a\u00a0meta-analysis. Afr Health Sci 2017; 17: 991-999.","DOI":"10.4314\/ahs.v17i4.6"},{"key":"ref-1692326","doi-asserted-by":"crossref","unstructured":"Sprovieri SR, Sens YA. Polymorphisms of\u00a0the\u00a0renin-angiotensin system genes in Brazilian patients with lupus nephropathy. Lupus 2005; 14: 356-362.\u00a0.","DOI":"10.1191\/0961203305lu2093oa"},{"key":"ref-1692327","doi-asserted-by":"crossref","unstructured":"Zhang X,\u00a0Wu L,\u00a0Chai M, et al. Angiotensin-converting enzyme insertion\/deletion polymorphism and susceptibility to Henoch- Sch\u00f6nlein purpura: a\u00a0meta-analysis. J Renin Angiotensin Aldosterone Syst 2019; 20: 1470320319836302.","DOI":"10.1177\/1470320319836302"},{"key":"ref-1692328","doi-asserted-by":"crossref","unstructured":"Rigat B,\u00a0Hubert C,\u00a0Alhenc-Gelas F, et al. An insertion\/deletion polymorphism in the\u00a0angiotensin I-converting enzyme gene accounting for half the\u00a0variance of\u00a0serum enzyme levels. J Clin Invest\u00a01990; 86: 1343-1346.","DOI":"10.1172\/JCI114844"},{"key":"ref-1692329","doi-asserted-by":"crossref","unstructured":"Perticone F,\u00a0Ceravolo R,\u00a0Maio R, et al. Angiotensin-converting enzyme gene polymorphism is associated with endotheliumdependent vasodilation in never treated hypertensive patients. 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