{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:48:32Z","timestamp":1782215312955,"version":"3.54.5"},"reference-count":27,"publisher":"Termedia Sp. z.o.o.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>This study aimed to evaluate the clinicopathologic significance of the combined immunohistochemical expression of the epithelial-mesenchymal transition marker E-cadherin and the angiogenesis marker CD105 in laryngeal squamous cell carcinoma and assess correlation of their expression. &lt;br \/&gt;\nEighty-five patients who underwent complete resection as primary treatment were selected for this study. E-cadherin and CD105 expression levels were determined by immunohistochemistry. The receiver operating curve approach was applied to determine the cut-off value and separate patients with high and low expression of markers. &lt;br \/&gt;\nThe high-risk group (\u201cCD105 high\u201d and \u201cE-cadherin low\u201d expression) showed statistically significant correlations with age less than 66 years (p = 0.039), advanced T-status (T3\u20134) (p = 0.046), aggressive TNM stage (stage III\u2013IV) (p = 0.003) and locoregional recurrence of disease (p = 0.004). In the Kaplan-Meier analyses, the high-risk group had significantly worse prognoses than other risk groups (log-rank test  \uf0632 = 9.415, p = 0.024). &lt;br \/&gt;\nSpearman\u2019s correlation coefficient analysis showed a\u00a0nonsignificant negative correlation between the expression of E-cadherin and CD105 (rho = \u20130.073,  p = 0.505). Simultaneous consideration of E-cadherin and CD105 is a\u00a0simple panel of markers to determine aggressive tumour phenotype with a\u00a0higher risk of disease recurrence in patients with laryngeal cancer.<\/jats:p>","DOI":"10.5114\/pjp.2023.134316","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:26:40Z","timestamp":1706516800000},"page":"225-231","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic significance of a\u00a0panel of two biomarkers (E-cadherin and CD105) in laryngeal cancer"],"prefix":"10.5114","volume":"74","author":[{"given":"Elvir","family":"Zvrko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljiljana","family":"Vuckovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miodrag","family":"Radunovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"ref-1691378","doi-asserted-by":"crossref","unstructured":"Sung H, Ferlay J, Siegel RL, et al. 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