{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:49:56Z","timestamp":1782215396047,"version":"3.54.5"},"reference-count":1,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>C1q\/TNF-related protein-9 (CTRP9) has been reported to play roles in several types of\u00a0retinal diseases. However, the\u00a0role and the\u00a0potential mechanism of\u00a0CTRP9 in glaucoma are still incompletely understood. The\u00a0expression of\u00a0CTRP9 in  OGD\/R-induced retinal ganglion cells (RGCs) was detected by quantitative  real-time polymerase chain reaction and western blot assay. &lt;br \/&gt;\nCell proliferation was identified by cell counting Kit-8 assay. Flow cytometry, enzyme-linked immunosorbent assay and western blot assay were performed to assess cell apoptosis. Unfolded protein response (UPR), endoplasmic reticulum (ER) stress and the\u00a0AMPK pathway were evaluated by western blot assay. &lt;br \/&gt;\nThe\u00a0data showed that the\u00a0expression of\u00a0CTRP9 was significantly downregulated in OGD\/R-induced 661W cells. OGD\/R treatment reduced cell viability, promoted cell apoptosis and activated the\u00a0UPR and ER stress. The\u00a0overexpression of\u00a0CTRP9 reversed the\u00a0effects of\u00a0OGD\/R on 661W cell viability, apoptosis, the\u00a0UPR and ER stress, as well as the\u00a0AMPK pathway. However, Compound C, an inhibitor of\u00a0AMPK signaling, reversed the\u00a0protection of\u00a0CTRP9 overexpression against injury from OGD\/R in 661W cells. &lt;br \/&gt;\nIn summary, the\u00a0results revealed that CTRP9 abated the\u00a0apoptosis and UPR of\u00a0OGD\/R-induced RGCs by regulating the\u00a0AMPK pathway, which may provide a\u00a0promising target for the\u00a0treatment of\u00a0glaucoma.<\/jats:p>","DOI":"10.5114\/pjp.2024.136025","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T05:22:05Z","timestamp":1712812925000},"page":"40-53","source":"Crossref","is-referenced-by-count":0,"title":["CTRP 9 mitigates the apoptosis and unfolded protein response of OGD\/R-induced retinal ganglion cells by regulating the AMPK pathway"],"prefix":"10.5114","volume":"75","author":[{"given":"Xiaofan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"ref-1689892","doi-asserted-by":"crossref","unstructured":"Kang JM, Tanna AP. Glaucoma. Med Clin N Am 2021; 105: 493-510.","DOI":"10.1016\/j.mcna.2021.01.004"}],"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-183030-141440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-183030-141440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:06:31Z","timestamp":1782212791000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/CTRP-9-mitigates-the-apoptosis-and-unfolded-protein-response-of-OGD-R-induced-retinal,183030,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,11]]},"references-count":1,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"alternative-id":["183030"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2024.136025","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,11]]}}}