{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T18:25:30Z","timestamp":1783362330952,"version":"3.54.6"},"reference-count":30,"publisher":"Termedia Sp. z.o.o.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Placental foetal vascular malperfusion (FVM) may be responsible for complicated foetal or neonatal condition. By highlighting endothelial fragmentation, the\u00a0double E-cadherin\/CD34 immunostain highlights distal villous endothelial fragmentation of\u00a0recent FVM not seen on haematoxylin-eosin stained sections. We routinely perform the\u00a0stain on a\u00a0grossly unremarkable placental sections of\u00a0placentas predominantly from pregnancies with mass-forming foetal anomalies and umbilical cord complications. The\u00a0stain can upgrade the\u00a0FVM and\/or reveal its temporal heterogeneity, both useful in establishing the\u00a0cause of\u00a0foetal death or poor neonatal condition. It also highlights the\u00a0basement membranes of\u00a0syncytiotrophoblastic cells which, in conjunction with endothelial staining, is helpful in the\u00a0diagnosis of\u00a0widening thereof in distal villous hypomaturity. It can distinguish mineralised stem occluding thrombi from mineralised trophoblastic pseudo inclusions \u2013 the\u00a0former outlined by CD34, the\u00a0latter by E-cadherin \u2013 thus helping to differentiate FVM from placental aneuploidies. The\u00a0E-cadherin component helps in the\u00a0diagnosis of\u00a0trophoblastic lesions of\u00a0shallow placental implantation featuring an increased number of\u00a0extravillous trophoblasts in placental membranes and chorionic disc. Therefore, the\u00a0double immunostain is helpful in histological diagnosis of\u00a0placental lesions and patterns of\u00a0injury.<\/jats:p>","DOI":"10.5114\/pjp.2024.142733","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T05:25:25Z","timestamp":1726032325000},"page":"171-181","source":"Crossref","is-referenced-by-count":2,"title":["E-cadherin\/CD34 double immunostaining in placental diagnosis"],"prefix":"10.5114","volume":"75","author":[{"given":"Jerzy","family":"Stanek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"ref-1688991","doi-asserted-by":"crossref","unstructured":"Fox H, Sebire NJ. Pathology of the placenta. Saunders, London 2007.","DOI":"10.1016\/B978-1-4160-2592-4.50018-7"},{"key":"ref-1688992","unstructured":"Heerema-McKenney A, Popek EJ, DePaepe ME (eds). Diagnostic pathology: placenta. 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