{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T07:56:35Z","timestamp":1793519795289,"version":"4.5.0"},"reference-count":11,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>To study the clinicopathological features of malignant transformation of the epithelial component of a\u00a0Warthin tumour into adenocarcinoma. The histological and immunophenotypic features of the malignant transformation of the epithelial component of a\u00a0Warthin tumour into adenocarcinoma were studied, and the literature was reviewed. The patient had a\u00a0history of surgery for a\u00a0Warthin tumour 3\u00a0years previously, and the typical histological manifestations of a\u00a0Warthin tumour were observed under the microscope following biopsy. Scattered tumour tissue infiltration was observed in the lymphatic interstitium, and a\u00a0transitional area of benign and malignant epithelial cells was observed locally. The\u00a0tumour cells were solid, nested, and glandular and grew infiltratively in the salivary gland tissue. There was diffuse positive staining for CK7 and CK19 in the cytoplasm of tumour cells. CK5\/6 was\u00a0positively expressed in the cytoplasm of basal cells in the tumour tissue, and P63 was positively expressed in the basal cell nuclei. Ki-67 positivity reached approximately 10% in tumour tissues. The\u00a0MAML2 fracture probe result was negative. The\u00a0final diagnosis was malignant transformation of a\u00a0Warthin tumour, with malignant transformation of epithelial components into adenocarcinoma. Malignant transformation of a\u00a0Warthin tumour is rare, and the intraoperative histopathological diagnosis based on frozen sectioning should be made with caution. The\u00a0key to diagnosis is to determine whether there is migration between benign and malignant epithelium.<\/jats:p>","DOI":"10.5114\/pjp.2025.149536","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T06:02:15Z","timestamp":1744869735000},"page":"64-69","source":"Crossref","is-referenced-by-count":2,"title":["Malignant transformation of the epithelial component of a\u00a0Warthin tumour into adenocarcinoma"],"prefix":"10.5114","volume":"76","author":[{"given":"WenBin","family":"Gou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BeiWen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KeJia","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Qiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"ref-1688551","doi-asserted-by":"crossref","unstructured":"Mylarappa DA, Haragannvar VC, Gopalkrishna AH, et\u00a0al. 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