{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:50:49Z","timestamp":1782215449720,"version":"3.54.5"},"reference-count":41,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>This study determined novel metabolism-related diagnostic biomarkers for ulcer\u00adative colitis (UC) and assessed their correlation with immune cell infiltration levels. Transcriptome data of UC was downloaded from the Gene Expression Omnibus (GEO) database, metabolism-related genes were summarised from the Gene Set Enrichment Analysis (GSEA) database. A total of 537 metabolism-related differen\u00adtially expressed genes (DEGs) in UC were applied to functional enrichment analy\u00adsis. We processed least absolute shrinkage and selection operator (LASSO) regres\u00adsion analysis and support vector machine-recursive feature elimination (SVM-RFE). We obtained 6 potential metabolism-related diagnostic biomarkers (CHST13, ETNK1, LPCAT1, PDE6A, PLA2G2A, and UGT2A3). Expression patterns and diagnostic ROC curves were depicted in both the training and testing co\u00adhorts to verify their diagnostic value. Immune infiltration analysis indicated that UC samples have more abundant infiltration levels of immune cells. Fur\u00adthermore, the upregulated diagnostic biomarkers significantly positively cor\u00adrelated with B cell memory, T cell CD4 memory activated, dendritic cells ac\u00adtivated, etc., while the downregulated ones mainly significantly positively correlated with mast cells resting, NK cells activated, and macrophages M2. Our study primarily identified 6 metabolism regulators (CHST13, ETNK1, LP\u00adCAT1, PDE6A, PLA2G2A, and UGT2A3) as potential diagnostic biomarkers for UC and determined their correlation with immune infiltration.<\/jats:p>","DOI":"10.5114\/pjp.2025.153972","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T09:21:34Z","timestamp":1758532894000},"page":"110-119","source":"Crossref","is-referenced-by-count":0,"title":["Identification of metabolism regulators as diagnostic markers for ulcerative colitis and their correlation with immune infiltration"],"prefix":"10.5114","volume":"76","author":[{"given":"Qilong","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"ref-1688083","doi-asserted-by":"crossref","unstructured":"Gros B, Kaplan GG. 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