{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:51:11Z","timestamp":1782215471799,"version":"3.54.5"},"reference-count":19,"publisher":"Termedia Sp. z.o.o.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Nevus sebaceous (NS) is a\u00a0benign hamartomatous lesion; however, benign proliferative lesions are less frequently associated with secondary neoplasms. The\u00a0aim of\u00a0this study is to evaluate the\u00a0prevalence of\u00a0secondary benign and malignant tumours seen in NS lesions, and to reveal the\u00a0histopathological features of\u00a0these lesions.&lt;br \/&gt;\nEighty-six NS cases were retrospectively evaluated for gender, age, lesion location, and accompanying lesions, as well as secondary benign and malignant tumours. The\u00a0data obtained using descriptive statistics were analysed.&lt;br \/&gt;\n66.3% of\u00a0cases were male, 33.7% were female, and the\u00a0mean age was 37.8 years. 61.6% of\u00a0lesions were localised on the\u00a0face, 37.2% on the\u00a0scalp, and 1.2% on the\u00a0back. Secondary lesion development was observed in 39.5% of\u00a0cases. The\u00a0most common malignancy, as reported in the\u00a0literature, was basal cell carcinoma.\u00a0 &lt;br \/&gt;\nAlthough secondary lesions, secondary tumours, and malignancy development are rare in NS lesions, careful follow-up and surgical excision if necessary are recommended, especially in adulthood. This study contributes to the\u00a0literature by revealing the\u00a0pathological characteristics of\u00a0secondary lesions accompanying NS, emphasising the\u00a0need for careful histological evaluation of\u00a0NS excisions in the\u00a0differential diagnosis and raising awareness that malignancies may be present.<\/jats:p>","DOI":"10.5114\/pjp.2025.157906","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:47:31Z","timestamp":1766155651000},"page":"233-238","source":"Crossref","is-referenced-by-count":0,"title":["A\u00a0retrospective analysis of\u00a0secondary malignancy development in nevus sebaceus"],"prefix":"10.5114","volume":"76","author":[{"given":"Fatma Seher","family":"Pehlivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer","family":"Atm\u0131\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanife Seda","family":"Mavili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyker","family":"Temiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref-1687823","doi-asserted-by":"crossref","unstructured":"Dowdle TS, Mehegran DA, Maldonado D, McCaughey CD. Multiple secondary neoplasms in nevus sebaceus excision. Proc (Bayl Univ Med Cent) 2021; 35: 241-242.","DOI":"10.1080\/08998280.2021.1988834"},{"key":"ref-1687824","unstructured":"Baigrie D, Troxell T, Cook C. Nevus sebaceus. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan."},{"key":"ref-1687825","doi-asserted-by":"crossref","unstructured":"Lei T, Lu Y, Feng Y, Ni Y. Case report: basal cell carcinoma arising within the\u00a0nevus sebaceous: report of\u00a04 cases and literature review. Front Oncol 2025; 14: 1478747.","DOI":"10.3389\/fonc.2024.1478747"},{"key":"ref-1687826","unstructured":"Calonje JE, Brenn T, Lazar AJ, Billings SD. mckee\u2019s pathology of\u00a0the\u00a0skin. 5th ed. Medipage, Warszawa 2019."},{"key":"ref-1687827","doi-asserted-by":"crossref","unstructured":"Kamyab-Hesari K, Seirafi H, Jahan S, Aghazadeh N, Hejazi P, Azizpour A, et al. Sebaceous nevus: a\u00a0clinicopathological study of\u00a0168 cases and review of\u00a0the\u00a0literature. Int J Dermatol 2016; 55: 193-200.","DOI":"10.1111\/ijd.12845"},{"key":"ref-1687828","doi-asserted-by":"crossref","unstructured":"Hsu MC, Liau JY, Hong JL, Cheng Y, Liao YH, Chen JS, et al. Secondary neoplasms arising from nevus sebaceus: a\u00a0retrospective study of\u00a0450 cases in Taiwan. J Dermatol 2016; 43: 175-180.","DOI":"10.1111\/1346-8138.13070"},{"key":"ref-1687829","doi-asserted-by":"crossref","unstructured":"Idriss MH, Elston DM. Secondary neoplasms associated with nevus sebaceus of\u00a0Jadassohn: a\u00a0study of\u00a0707 cases. J Am Acad Dermatol 2014; 70: 332-337.","DOI":"10.1016\/j.jaad.2013.10.004"},{"key":"ref-1687830","doi-asserted-by":"crossref","unstructured":"Aslam A, Salam A, Griffiths CE, McGrath JA. Sebaceous nevus: a\u00a0mosaic RASopathy. Clin Exp Dermatol 2014; 39: 1-6.","DOI":"10.1111\/ced.12209"},{"key":"ref-1687831","doi-asserted-by":"crossref","unstructured":"Groesser L, Herschberger E, Ruetten A, Ruivenkamp C, Lopriore E, Zutt M, et al. Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. Nat Genet 2012; 44: 783-787.","DOI":"10.1038\/ng.2316"},{"key":"ref-1687832","doi-asserted-by":"crossref","unstructured":"Kim YS, Park GS, Chung YJ, Lee JH. Whole-exome sequencing of\u00a0secondary tumors arising from nevus sebaceous revealed additional genomic alterations besides RAS mutations. J Dermatol 2023; 50: 1072-1075.","DOI":"10.1111\/1346-8138.16784"},{"key":"ref-1687833","doi-asserted-by":"crossref","unstructured":"Ye Q, Wu Q, Jia M, Li FZ, Fang S. Secondary tumors arising from nevus sebaceus: a\u00a0multicenter collaborative study and literature review. Dermatology 2023; 239: 140-147.","DOI":"10.1159\/000526143"},{"key":"ref-1687834","doi-asserted-by":"crossref","unstructured":"Pang S, Cevik J, Sreedharan S, Wilks DJ. Rate of\u00a0benign and malignant secondary tumors associated with nevus sebaceous: a\u00a0systematic review and meta-analysis. Ann Plast Surg 2024; 92: 711-719.","DOI":"10.1097\/SAP.0000000000003879"},{"key":"ref-1687835","doi-asserted-by":"crossref","unstructured":"Silva Neto MP, de Assis BR, Andrade GR. Sebaceous nevus of\u00a0Jadassohn: review and clinical-surgical approach. An Bras Dermatol 2022; 97: 628-636.","DOI":"10.1016\/j.abd.2021.11.001"},{"key":"ref-1687836","doi-asserted-by":"crossref","unstructured":"Kong SH, Han SH, Kim JH, Oh YW, Park HJ, Suh HS, et al. Optimal timing for surgical excision of\u00a0sebaceous nevus on the\u00a0scalp: a\u00a0single-center experience. Dermatol Surg 2020; 46: 20-25.","DOI":"10.1097\/DSS.0000000000001915"},{"key":"ref-1687837","doi-asserted-by":"crossref","unstructured":"Hashem R, Tynng\u00e5rd N, Lundmark K, Falk L. Microcystic adnexal carcinoma originating in a\u00a0sebaceous nevus: a\u00a0case report of\u00a0a\u00a016-year-old boy. Acta Derm Venereol 2019; 99: 1182-1183.","DOI":"10.2340\/00015555-3272"},{"key":"ref-1687838","doi-asserted-by":"crossref","unstructured":"Pepi C, de Palma L, Trivisano M, Pietrafusa N, Lepri FR, Diociaiuti A, et al. The\u00a0role of\u00a0KRAS mutations in cortical malformation and epilepsy surgery: a\u00a0novel report of\u00a0nevus sebaceous syndrome and review of\u00a0the\u00a0literature. Brain Sci 2021; 11: 793.","DOI":"10.3390\/brainsci11060793"},{"key":"ref-1687839","doi-asserted-by":"crossref","unstructured":"Happle R. Nevus sebaceus is a\u00a0mosaic RASopathy. J Invest Dermatol 2013; 133: 597-600.","DOI":"10.1038\/jid.2012.447"},{"key":"ref-1687840","doi-asserted-by":"crossref","unstructured":"Pan C, Zhou X, Hong A, Fang F,\u00a0Wang Y. Identification of\u00a0KRAS mutation in a\u00a0patient with linear nevus sebaceous syndrome: a\u00a0case report. BMC Med Genomics 2020; 13: 188.","DOI":"10.1186\/s12920-020-00847-1"},{"key":"ref-1687841","doi-asserted-by":"crossref","unstructured":"Fernandes DA, Sang K, Sperling L. Sebaceous nevus with novel HRAS sequence variant mutation misdiagnosed as alopecia areata. Cutis 2023; 111: E30-E32.","DOI":"10.12788\/cutis.0780"}],"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-213691-136506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-213691-136506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:15:26Z","timestamp":1782213326000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/A-retrospective-analysis-of-secondary-malignancy-development-in-nevus-sebaceus,213691,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"alternative-id":["213691"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2025.157906","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]}}}