{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:51:14Z","timestamp":1782215474676,"version":"3.54.5"},"reference-count":20,"publisher":"Termedia Sp. z.o.o.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Borderline ovarian tumors (BOT) in effusion cytology are rare, and to date only limited literature has existed. &lt;br \/&gt;\nThe\u00a0current study used the\u00a0International System for Reporting Fluid Cytopathology (ISRSFC) criteria to reclassify 321 effusion cytology cases from 302 patients, analyzed diagnostic performance among different positive groups and evaluated the\u00a0risk of\u00a0malignancy (ROM). A\u00a0total of\u00a014 BOTs were included, majority of\u00a0them were mucinous borderline and these tumors were reclassified into atypia of\u00a0uncertain significance (AUS) and suspicious for malignancy (SFM) intermediate categories. According to ISRSFC criteria, effusion cases were categorized into five different groups: non-diagnostic (ND), negative for malignancy, AUS, SFM and malignant. &lt;br \/&gt;\nThe\u00a0corresponding overall ROMs were 23.3%, 19.4%, 44%, 87.8% and 100%. Morphologically, mucinous BOTs in effusions presented mostly as acellular mucin, while serous BOTs exhibited mesothelial cells with few atypical cells showing mild to moderate nuclear atypia. &lt;br \/&gt;\nThese findings highlight the\u00a0diagnostic difficulty of\u00a0BOTs in effusion cytology and the\u00a0need to apply ISRSFC criteria especially for AUS and SFM grey zone categories for standard reporting and clinical guidance.<\/jats:p>","DOI":"10.5114\/pjp.2025.159329","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T10:21:22Z","timestamp":1772533282000},"page":"329-337","source":"Crossref","is-referenced-by-count":0,"title":["Towards standardized categorization of\u00a0serous effusions: application of\u00a0the\u00a0International System for Reporting Serous Fluid Cytopathology diagnostic framework with a\u00a0special emphasis on borderline ovarian tumors"],"prefix":"10.5114","volume":"76","author":[{"given":"Suguna","family":"Badiginchala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhuja","family":"GV","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukmangadha","family":"Nandyala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna Kumari","family":"Prayaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"ref-1687572","doi-asserted-by":"crossref","unstructured":"Zamboni MM, da Silva CT Jr., Baretta R, Cunha ET, Cardo-\u00ad\u00ad so GP. Important prognostic factors for survival in patients with malignant pleural effusion. BMC Pulm Med 2015; 15: 29.","DOI":"10.1186\/s12890-015-0025-z"},{"key":"ref-1687573","doi-asserted-by":"crossref","unstructured":"Chandra A, Crothers B, Kurtycz D, Schmitt F. Announcement: the\u00a0International System for Reporting Serous Fluid Cytopathology. Acta Cytol 2019; 63: 349-351.","DOI":"10.1159\/000501536"},{"key":"ref-1687574","doi-asserted-by":"crossref","unstructured":"Chandra A, Crothers B, Kurtycz D, Schmitt F. The\u00a0International System for Reporting Serous Fluid Cytopathology. 1st ed. Cham: Springer, Berlin 2020.\u00a0.","DOI":"10.1007\/978-3-030-53908-5_1"},{"key":"ref-1687575","doi-asserted-by":"crossref","unstructured":"Srinivasan R, Rekhi B, Rajwanshi A, Pathuthara S, Mathur S, Jain D, et al. Indian Academy of\u00a0Cytologists Guidelines for Collection, Preparation, Interpretation, and Reporting of\u00a0Serous Effusion Fluid Samples. J Cytol 2020; 37: 1-11.","DOI":"10.4103\/JOC.JOC_157_19"},{"key":"ref-1687576","doi-asserted-by":"crossref","unstructured":"Kundu R, Srinivasan R, Dey P, Gupta N, Gupta P, Rohilla M, et al. Application of\u00a0Indian Academy of\u00a0Cytologists guidelines for reporting serous effusions: an institutional experience.  J Cytol 2021; 38: 1-7.","DOI":"10.4103\/JOC.JOC_224_20"},{"key":"ref-1687577","doi-asserted-by":"crossref","unstructured":"Yang H, Zhu J, Wang P. Application of\u00a0the\u00a0International System for Reporting Serous Fluid Cytopathology (ISRSFC) in reporting serous effusion. A\u00a0retrospective study. Medicine 2023; 102: 43.","DOI":"10.1097\/MD.0000000000035707"},{"key":"ref-1687578","doi-asserted-by":"crossref","unstructured":"Pergaris A, Stefanou D, Keramari P, Sousouris S, Kavantzas N, Gogas H, et al. Application of\u00a0the\u00a0International System for Reporting Serous Fluid Cytopathology with Cytohistological Correlation and Risk of\u00a0Malignancy Assessment. Diagnostics (Basel) 2021; 11: 2223.","DOI":"10.3390\/diagnostics11122223"},{"key":"ref-1687579","doi-asserted-by":"crossref","unstructured":"Straccia P, Chiappetta M, Magnini D, Cancellieri A. Application of\u00a0the\u00a0International System for Reporting Serous Fluid Cytopathology (TIS): a\u00a0retrospective institutional study. Cytopathology 2022; 33: 305-311.","DOI":"10.1111\/cyt.13113"},{"key":"ref-1687580","doi-asserted-by":"crossref","unstructured":"Rooper LM,\u00a0Ali SZ,\u00a0Olson MT.\u00a0A\u00a0minimum fluid volume of\u00a0 75 ml is needed to ensure adequacy in a\u00a0pleural effusion: a\u00a0retrospective analysis of\u00a02540 cases.\u00a0Cancer Cytopathol\u00a02014;\u00a0122: 657-665.","DOI":"10.1002\/cncy.21452"},{"key":"ref-1687581","doi-asserted-by":"crossref","unstructured":"Pinto D, Cruz E, Branco D, Linares C, Carvalho C, Silva A, et al. Cytohistological correlation in pleural effusions based on the\u00a0International System for Reporting Serous Fluid Cytopathology. Diagnostics (Basel) 2021; 11: 1126.","DOI":"10.3390\/diagnostics11061126"},{"key":"ref-1687582","doi-asserted-by":"crossref","unstructured":"Lobo C, Costa J, Petronilho S, Monteiro P, Le\u00e7a L, Schmitt F. Cytohistological correlation in serous effusions using the\u00a0newly proposed International System for Reporting Serous Fluid Cytopathology: Experience of\u00a0an oncological center. Diagn Cytopathol 2021; 49: 596-605.","DOI":"10.1002\/dc.24440"},{"key":"ref-1687583","doi-asserted-by":"crossref","unstructured":"Rakheja G, Singh M, Priyadarshnee B, Marimuthu B, Dhar L, Jain S, et al. Categorisation of\u00a0peritoneal serous effusions using the\u00a0International System for Reporting Serous Fluid Cytopathology \u2013 a\u00a0study on gynaecological samples. Cytopathology 2023; 34: 138-145.","DOI":"10.1111\/cyt.13201"},{"key":"ref-1687584","doi-asserted-by":"crossref","unstructured":"Rajeswaran PK, Srinivasan V, Mahesh SSV, Ashok AU. A\u00a0retrospective analysis of\u00a0the\u00a0application of\u00a0the\u00a0newly proposed International System for Reporting Serous Fluid Cytopathology on serous effusion specimens: an institutional experience. Acta Cytologica 2023; 67: 70\u201179.","DOI":"10.1159\/000527398"},{"key":"ref-1687585","doi-asserted-by":"crossref","unstructured":"Song MJ, Jo U, Jeong JS, Cho KJ, Gong G, Cho YM, et al. Clinico-cytopathologic analysis of\u00a0574 pericardial effusion specimens: application of\u00a0the\u00a0international system for reporting serous fluid cytopathology (ISRSFC) and long-term clinical  follow-up. Cancer Med 2021; 10: 8899-908.","DOI":"10.1002\/cam4.4408"},{"key":"ref-1687586","doi-asserted-by":"crossref","unstructured":"Wang M, Sun T, Jiao J, Wang H. Application of\u00a0the\u00a0International System for Reporting Serous Fluid Cytopathology to pericardial fluid: root-cause analysis of\u00a0indeterminate diagnoses, cyto-histological correlation, and assessment of\u00a0risk of\u00a0malignancy. Cancer Cytopathol 2023; 131: 433-441.","DOI":"10.1002\/cncy.22696"},{"key":"ref-1687587","doi-asserted-by":"crossref","unstructured":"Da Silva DJC, Dos Santos CR, Xavier-J\u00fanior JCC. Risk of\u00a0Malignancy in Effusions according to the\u00a0International System for Serous Fluid Cytopathology: a\u00a0review. Acta Cytol 2024; 68: 384-393.","DOI":"10.1159\/000540414"},{"key":"ref-1687588","doi-asserted-by":"crossref","unstructured":"Zhu YL, Ren WH, Wang Q, Jin HZ, Guo YY, Lin DM. A\u00a0retrospective analysis of\u00a0serous effusions based on the\u00a0newly proposed international system for reporting serous fluid cytopathology: a\u00a0report of\u00a03633 cases in an oncological center. Diagn Path 2022; 17: 56.","DOI":"10.1186\/s13000-022-01241-4"},{"key":"ref-1687589","doi-asserted-by":"crossref","unstructured":"Sharma S, Mohapatra DS, Gupta N, Srinivasan R, Rajwanshi A, Dey P. Cytology of\u00a0peritoneal implants of\u00a0borderline serous tumor of\u00a0ovaries in ascitic fluid. Cytojournal 2021; 18: 17.","DOI":"10.25259\/Cytojournal_56_2020"},{"key":"ref-1687590","doi-asserted-by":"crossref","unstructured":"Lu CH, Liu CY, Jhuang JY, Chen CC. Comprehensive evaluation of\u00a0benign and malignant etiologies of\u00a0different serous effusions with the\u00a0International System for Reporting Serous Fluid Cytopathology: a\u00a0multi-institutional study in Taiwan. Cancer Cytopathol 2024; 132: 169-178.","DOI":"10.1002\/cncy.22783"},{"key":"ref-1687591","doi-asserted-by":"crossref","unstructured":"Lim KH, Ahmed SS, Cheng XM, Hwang JSG, Karunanithi J, Mantoo S et al. A\u00a0single tertiary institution review of\u00a0the\u00a0International System for Serous Fluid Cytopathology and the\u00a0impact of\u00a0cell block and ancillary studies on its performance.  J Am Soc Cytopathol 2023; 12: 48-57.","DOI":"10.1016\/j.jasc.2022.09.001"}],"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-214442-136495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-214442-136495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:15:54Z","timestamp":1782213354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/Towards-standardized-categorization-of-serous-effusions-application-of-the-International,214442,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"alternative-id":["214442"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2025.159329","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]}}}