{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T11:11:29Z","timestamp":1760613089487,"version":"build-2065373602"},"reference-count":16,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Radiol"],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>The objective of this study is to analyse the characteristics of hepatic haemodynamics disturbances identified through perfusion computed tomography (PCT) in patients with portal hypertension of various aetiologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The study included 110 individuals aged 18 to 67 years, divided into 4 groups based on the degree of portal circulation impairment: 63 patients with intrahepatic postsinusoidal occlusion associated with liver cirrhosis; 10 patients with intrahepatic presinusoidal occlusion associated with liver fibrosis (LF); 13 patients with intrahepatic occlusion in extrahepatic portal hypertension (EPH); and a\u00a0control group of 24 healthy volunteers. The average age of the participants was 38.6 \u00b1 1.1 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PCT of the liver is a\u00a0valuable diagnostic tool for assessing the arterial fraction (AF), portal fraction (PF), and portal index (PI), providing insights into haemodynamic changes in portal hypertension. In presinusoidal obstruction (as in LF), the PF increases, while in cirrhosis with post-sinusoidal obstruction, it decreases with a\u00a0compensatory rise in arterial perfusion and PI. The most significant changes occur in infrahepatic obstruction, marked by reduced or absent portal flow and a\u00a0sharply elevated PI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In LF, preserved PF with slight AF and moderate PI increases suggests early vascular remodeling with limited arterial compensation. Cirrhosis showed reduced PF and elevated AF and PI, reflecting increased sinusoidal resistance. In EPH, PF was markedly decreased with pronounced AF and PI elevations, indicating strong arterial compensation. In congenital cavernous transformation, AF exceeded cirrhotic levels, pointing to early and dominant arterial substitution.<\/jats:p><\/jats:sec>","DOI":"10.5114\/pjr\/207720","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:34:56Z","timestamp":1760610896000},"page":"490-497","source":"Crossref","is-referenced-by-count":0,"title":["Portal hypertension of diverse origins: Special features of hepatic hemodynamics based on perfusion computed tomography assessment"],"prefix":"10.5114","volume":"90","author":[{"given":"Nigora","family":"Djurayeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adham","family":"Ikramov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azam","family":"Babadzhanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aybek","family":"Amirkhamzaev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khanum","family":"Abdulkhalimova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khakim","family":"Shamirzaev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisher","family":"Sultanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saodat","family":"Magzumova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"ref-1563483","doi-asserted-by":"crossref","unstructured":"Nazyrov FG, Devyatov AV, Babadzhanov AKh, Raimov SA. Peculiarities of development and course of liver cirrhosis complications depending on the etiological factor. Novosti Khirurgii 2013; 21: 45-50 [In Russian].","DOI":"10.18484\/2305-0047.2013.4.45"},{"key":"ref-1563484","unstructured":"The World Health Organization. Global Burden of Disease Study 2017. Availbale at: https:\/\/ghdx.healthdata.org\/gbd-2017."},{"key":"ref-1563485","doi-asserted-by":"crossref","unstructured":"Cosgrove D, Piscaglia F, Bamber J, Bojunga J, Correas JM, Gilja OH, et al. EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 2: Clinical applications. Ultraschall Med 2013; 34: 238-253.","DOI":"10.1055\/s-0033-1335375"},{"key":"ref-1563486","doi-asserted-by":"crossref","unstructured":"Yoon JH, Lee JM, Klotz E, Jeon JH, Lee KB, Han JK, Choi BI. Estimation of hepatic extracellular volume fraction using multiphasic liver computed tomography for hepatic fibrosis grading. Invest. Radiol 2015; 50: 290-296.","DOI":"10.1097\/RLI.0000000000000123"},{"key":"ref-1563488","doi-asserted-by":"crossref","unstructured":"Rossle M, Blanke P, Fritz B, et al. Free hepatic vein pressure is not useful to calculate the portal pressure gradient in cirrhosis: a\u00a0morphologic and hemodynamic study. J Vasc Interv Radiol 2016; 27: 1130-1137.","DOI":"10.1016\/j.jvir.2016.03.028"},{"key":"ref-1563489","doi-asserted-by":"crossref","unstructured":"Silva-Junior G, Baiges A, Turon F, et al. The prognostic value of hepatic venous pressure gradient in patients with cirrhosis is highly dependent on the accuracy of the technique. Hepatology 2015; 62: 1584-1592.","DOI":"10.1002\/hep.28031"},{"key":"ref-1563490","doi-asserted-by":"crossref","unstructured":"Bonekamp D, Bonekamp S, Geiger B, Kamel IR. An elevated arterial enhancement fraction is associated with clinical and imaging indices of liver fibrosis and cirrhosis. J Comput Assist Tomogr 2012; 36: 681-689.","DOI":"10.1097\/RCT.0b013e3182702ee3"},{"key":"ref-1563491","unstructured":"Wang L, Fan J, Ding X, Sun J, Zhang M. Assessment of liver fibrosis in the early stages with perfusion CT. Int J Clin Exp Med 2015; 8: 15276-15282."},{"key":"ref-1563492","doi-asserted-by":"crossref","unstructured":"Van Beers BE, Leconte I, Materne R, Smith AM, Jamart J, Horsmans Y. Hepatic perfusion parameters in chronic liver disease: dynamic CT measurements correlated with disease severity. AJR Am J Roentgenol 2001; 176: 667-673.","DOI":"10.2214\/ajr.176.3.1760667"},{"key":"ref-1563493","doi-asserted-by":"crossref","unstructured":"Chen ML, Zeng QY, Huo JW, et al. Assessment of the hepatic microvascular changes in liver cirrhosis by perfusion computed tomography. World J Gastroenterol 2009; 15: 3532-3537.","DOI":"10.3748\/wjg.15.3532"},{"key":"ref-1563494","doi-asserted-by":"crossref","unstructured":"Kumar M, Sakhuja P, Kumar A, et al. Histological subclassification of cirrhosis based on histological-haemodynamic correlation. Aliment Pharmacol Ther 2008; 27: 771-779.","DOI":"10.1111\/j.1365-2036.2008.03653.x"},{"key":"ref-1563495","doi-asserted-by":"crossref","unstructured":"Bandula S, Punwani S, Rosenberg WM, Jalan R, Hall AR, Dhillon A, Moon JC, Taylor SA. Equilibrium contrast-enhanced CT imaging to evaluate hepatic fibrosis: initial validation by comparison with histopathologic sampling. Radiology 2015; 275: 136-143.","DOI":"10.1148\/radiol.14141435"},{"key":"ref-1563496","doi-asserted-by":"crossref","unstructured":"Dai DF, Swanson PE, Krieger EV, Liou IW, Carithers RL, Yeh MM. Congestive hepatic fibrosis score: a\u00a0novel histologic assessment of clinical severity. Mod Pathol 2014; 27: 1552-1558.","DOI":"10.1038\/modpathol.2014.79"},{"key":"ref-1563497","doi-asserted-by":"crossref","unstructured":"Hytiroglou P, Snover DC, Alves V. et al. Beyond \u2018cirrhosis\u2019 A\u00a0proposal from the International Liver Pathology Study Group. Am J Clin Pathol 2012; 137: 5-9.","DOI":"10.1309\/AJCP2T2OHTAPBTMP"},{"key":"ref-1563498","doi-asserted-by":"crossref","unstructured":"Kar\u00e7aaltincaba M, Sirlin CB. CT and MRI of diffuse lobar involvement pattern in liver pathology. Diagn Interv Radiol 2011; 17: 334-342.","DOI":"10.4261\/1305-3825.DIR.4033-10.0"},{"key":"ref-1563499","doi-asserted-by":"crossref","unstructured":"Liu C, Song JL, Lu WS, Yang JY, et al. Hepatic arterial buffer response maintains the homeostasis of graft hemodynamics in patient receiving living donor liver transplantation. 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