{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:42:20Z","timestamp":1788925340721,"version":"build-2803163510"},"reference-count":28,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Radiol"],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Tubal patency examination is an essential part of the infertility workup; HyFoSy is a recommended substitute for the standard Hystero-Salpingo Graphy (HSG). This study aims to determine the diagnostic concordance of HyFoSy and  HSG and to determine impact of uterus position on test performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>A prospective observational cohort study enrolled 80 infertile women referred for assessing tubal patency at Al Yarmouk Hospital.Parameters recorded: demographics ( age, parity, uterus position) and tubal patency test interpreted ( patent, unilateral, or bilateral blocked tubes). HyFoSy was performed first, followed by HSG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Age and parity were insignificant. HyFoSy showed a high degree of diagnostic concordance with HSG ( 85%) with 0.3 (95% CI: 0.05\u20130.55) Cohen's kappa coefficient . Gwet's AC1 coefficient was 0.84 (95% CI: 0.74\u20130.94), indicating strong agreement. McNemar's test revealed significant systematic bias between the methods (P &lt; 0.001), suggesting that HyFoSy and HSG are not interchangeable, which was further confirmed by Bland-Altman analysis showing a mean bias of +0.25 in favor of HyFoSy.The latter has a tendency to overestimate tubal patency among women with a retroverted uterus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HyFoSy is a promising tool to be used as a complementary infertility test showing high concordance with HSG. However, it should not be used as a stand-in for HSG without clinical judgment, especially in women with a retroverted uterus. The best of both approaches may be provided by a hybrid strategy that uses HyFoSy as a first-line test and saves HSG for cases that are unclear or high-risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/pjr\/216144","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:36:14Z","timestamp":1778931374000},"page":"222-229","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic performance of HyFoSy versus HSG for tubal patency: accuracy and agreement analysis"],"prefix":"10.5114","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7029-0451","authenticated-orcid":true,"given":"Shaymaa K.","family":"Abdulqader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassan","family":"Nori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajaa A.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wisam","family":"Akram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8964-8943","authenticated-orcid":true,"given":"Nabeeha N.","family":"Akram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"ref-1864595","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2024.104380"},{"key":"ref-1864596","doi-asserted-by":"crossref","unstructured":"Tanaka K, Chua J, Cincotta R, Ballard EL, Duncombe G. Hysterosalpingo-foam sonography (HyFoSy): tolerability, safety and the occurrence of pregnancy post-procedure. Aust N Z J Obstet Gynaecol 2018; 58: 114-118.","DOI":"10.1111\/ajo.12716"},{"key":"ref-1864597","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2020.102004"},{"key":"ref-1864598","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-022-01606-3"},{"key":"ref-1864599","doi-asserted-by":"crossref","unstructured":"Lo Monte G, Capobianco G, Piva I, Caserta D, Dessole S, Marci R. Hysterosalpingo contrast sonography (HyCoSy): let\u2019s make the point! Arch Gynecol Obstet 2015; 291: 19-30.","DOI":"10.1007\/s00404-014-3465-4"},{"key":"ref-1864600","doi-asserted-by":"crossref","unstructured":"Boned-L\u00f3pez J, Alc\u00e1zar JL, Errasti T, Ruiz-Zambrana A, Rodriguez I, Pascual MA, Guerriero S. Severe pain during hysterosalpingo-contrast sonography (HyCoSy): a systematic review and meta-analysis. Arch Gynecol Obstet 2021; 304: 1389-1398.","DOI":"10.1007\/s00404-021-06188-3"},{"key":"ref-1864601","doi-asserted-by":"crossref","unstructured":"Frinking P, Segers T, Luan Y, Tranquart F. Three decades of ultrasound contrast agents: a review of the past, present and future improvements. Ultrasound Med Biol 2020; 46: 892-908.","DOI":"10.1016\/j.ultrasmedbio.2019.12.008"},{"key":"ref-1864602","doi-asserted-by":"crossref","unstructured":"Lim SL, Jung JJ, Yu SL, Rajesh H. A comparison of hysterosalpingo-foam sonography (HyFoSy) and hysterosalpingo-contrast sonography with saline medium (HyCoSy) in the assessment of tubal patency. Eur J Obstet Gynecol Reprod Biol 2015; 195: 168-172.","DOI":"10.1016\/j.ejogrb.2015.10.008"},{"key":"ref-1864603","doi-asserted-by":"crossref","unstructured":"Rajesh H, Lim SL, Yu SL. Hysterosalpingo-foam sonography: patient selection and perspectives. Int J Womens Health 2017; 9: 23-32.","DOI":"10.2147\/IJWH.S123710"},{"key":"ref-1864604","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead093.325"},{"key":"ref-1864605","doi-asserted-by":"crossref","unstructured":"Kamphuis D, van Eekelen R, van Welie N, Dreyer K, van Rijswijk J, van Hooff MHA, et al. Hysterosalpingo-foam sonography versus hysterosalpingography during fertility workup: an economic evaluation alongside a randomized controlled trial. Hum Reprod 2024; 39: 1222-1230.","DOI":"10.1093\/humrep\/deae071"},{"key":"ref-1864606","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11195946"},{"key":"ref-1864607","doi-asserted-by":"crossref","unstructured":"Nori W, Helmi ZR. Can follicular fluid 8-oxo-2\u00a2-deoxyguanosine predict the clinical outcomes in ICSI cycle among couples with normospermia male? Obstet Gynecol Sci 2023; 66: 430-440.","DOI":"10.5468\/ogs.22170"},{"key":"ref-1864608","doi-asserted-by":"crossref","unstructured":"Van Welie N, van Rijswijk J, Dreyer K, van Hooff MH, Peter de Bruin J, Verhoeve HR, et al. Can hysterosalpingo-foam sonography replace hysterosalpingography as first-choice tubal patency test? A randomized non-inferiority trial. Hum Reprod 2022; 37: 969-979.","DOI":"10.1093\/humrep\/deac034"},{"key":"ref-1864609","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10184169"},{"key":"ref-1864610","doi-asserted-by":"crossref","unstructured":"McHugh ML. Interrater reliability: the kappa statistic. Biochem Med (Zagreb) 2012; 22: 276-282.","DOI":"10.11613\/BM.2012.031"},{"key":"ref-1864611","doi-asserted-by":"crossref","unstructured":"Emanuel MH, van Vliet M, Weber M, Exalto N. First experiences with hysterosalpingo-foam sonography (HyFoSy) for office tubal patency testing. Hum Reprod 2011; 27: 114-117.","DOI":"10.1093\/humrep\/der367"},{"key":"ref-1864612","doi-asserted-by":"crossref","unstructured":"Li Y, Chen X, Wang Q, Wang J. Factors influencing the visualization of fallopian tubes in hysterosalpingo-contrast sonography (HyCoSy) \u2013 the value of multimodal HyCoSy in visualizing the fallopian tubes. J Ultrasound Med 2024; 43: 1957-1967.","DOI":"10.1002\/jum.16530"},{"key":"ref-1864613","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-025-03598-2"},{"key":"ref-1864614","doi-asserted-by":"crossref","unstructured":"Revzin MV, Moshiri M, Katz DS, Pellerito JS, Gettle LM, Menias CO. Imaging evaluation of fallopian tubes and related disease: a primer for radiologists. Radiographics 2020; 40: 1473-1501.","DOI":"10.1148\/rg.2020200051"},{"key":"ref-1864615","doi-asserted-by":"crossref","unstructured":"Exacoustos C, Pizzo A, Lazzeri L, Pietropolli A, Piccione E, Zupi E. Three-dimensional hysterosalpingo contrast sonography with gel foam: methodology and feasibility to obtain 3-dimensional volumes of tubal shape. J Minim Invasive Gynecol 2017; 24: 827-832.","DOI":"10.1016\/j.jmig.2017.04.007"},{"key":"ref-1864616","doi-asserted-by":"crossref","unstructured":"Grigovich M, Kacharia VS, Bharwani N, Hemingway A, Mijatovic V, Rodgers SK. Evaluating fallopian tube patency: what the radiologist needs to know. Radiographics 2021; 41: 1876-1896.","DOI":"10.1148\/rg.2021210033"},{"key":"ref-1864617","doi-asserted-by":"crossref","unstructured":"Rajesh H, Lim SL, Yu SL. Hysterosalpingo-foam sonography: patient selection and perspectives. Int J Womens Health 2016; 9: 23-32.","DOI":"10.2147\/IJWH.S123710"},{"key":"ref-1864618","doi-asserted-by":"crossref","unstructured":"Piccioni MG, Riganelli L, Filippi V, Fuggetta E, Colagiovanni V, Imperiale L, et al. Sonohysterosalpingography: comparison of foam and saline solution. J Clin Ultrasound 2017; 45: 67-71.","DOI":"10.1002\/jcu.22412"},{"key":"ref-1864619","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20201386"},{"key":"ref-1864620","doi-asserted-by":"crossref","unstructured":"Le Lous M, Klein M, Tesson C, Berthelemy J, Lavoue V, Jannin P. Metrics used to evaluate obstetric ultrasound skills on simulators: a systematic review. Eur J Obstet Gynecol Reprod Biol 2021; 258: 16-22.","DOI":"10.1016\/j.ejogrb.2020.12.034"},{"key":"ref-1864621","doi-asserted-by":"publisher","DOI":"10.47723\/nz221421"},{"key":"ref-1864622","doi-asserted-by":"crossref","unstructured":"Wong SC, Yung KS, Chan RL, Luk WH. Hysterosalpingographic findings from uterus to peritoneal cavity: a pictorial essay. Hong Kong J Radiol 2023, 26: 153-160.","DOI":"10.12809\/hkjr2317410"}],"container-title":["Polish Journal of Radiology"],"original-title":[],"link":[{"URL":"https:\/\/www.polradiol.com\/pdf-216144-139996","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polradiol.com\/pdf-216144-139996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:36:23Z","timestamp":1778931383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polradiol.com\/Diagnostic-performance-of-HyFoSy-versus-HSG-for-tubal-patency-accuracy-and-agreement,216144,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,16]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"alternative-id":["216144"],"URL":"https:\/\/doi.org\/10.5114\/pjr\/216144","relation":{},"ISSN":["1899-0967"],"issn-type":[{"value":"1899-0967","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,16]]}}}