{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:39:35Z","timestamp":1787031575410,"version":"build-2736575974"},"reference-count":27,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Radiol"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Right ventricular (RV) outflow tract obstruction (RVOTO) was demonstrated to be protective against RV dilatation in patients with repaired tetralogy of Fallot and chronic pulmonary regurgitation (PR). We hypothesised that the presence of additional haemodynamic abnormalities (more than mild tricuspid regurgitation, residual ventricular septal defect) reduces this protective association. Accordingly, we aimed to assess the impact of PR on RV size and function in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>Consecutive patients with additional haemodynamic abnormalities after tetralogy of Fallot (TOF) repair, who had undergone cardiovascular magnetic resonance, were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 90 patients studied, 18 individuals (mean age 32.5 \u00b1 10.7 years, 72.2% males) met the inclusion criteria. There were no differences in RV volumes and ejection fraction between patients with and without RVOTO. Neither PR fraction (PRF) nor PR volume (PRV) correlated with RV end-diastolic volume (r = 0.36; p = 0.15 and r = 0.37; p = 0.14, respectively, for PRF and PRV) or RV end-systolic volume (r = 0.2; p = 0.42 and r = 0.19; p = 0.45, respectively, for PRF and PRV). Similarly, no significant correlations were observed between PRF or PRV and RV ejection fraction (r = \u20130.04; p = 0.87 and r = \u20130.03; p = 0.9, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Additional haemodynamic abnormalities are associated with the abolition of the protective effect of RVOTO on RV size. There was no significant relationship between measures of PR and RV volumes in patients after TOF repair with concomitant haemodynamic abnormalities. These abnormalities acted as confounding factors in the assessment of the impact of pulmonary regurgitation on RV size and function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/pjr.2020.101058","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T15:35:56Z","timestamp":1609774556000},"page":"607-612","source":"Crossref","is-referenced-by-count":7,"title":["The impact of pulmonary regurgitation on right ventricular size and function in patients with repaired tetralogy of Fallot and additional haemodynamic abnormalities"],"prefix":"10.5114","volume":"85","author":[{"given":"Mateusz","family":"\u015apiewak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Petryka-Mazurkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Mazurkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Mi\u0142osz-Wieczorek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miros\u0142aw","family":"Kowalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta K.","family":"Biernacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Marczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"ref-1142896","first-page":"e714","article-title":"ACC\/AHA 2008 Guidelines for the Management of Adults with Congenital Heart Disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (writing committee to develop guidelines on the management of adults with congenital heart disease)","volume":"118","author":"Warnes CA","year":"2008","unstructured":"Warnes CA, Williams RG, Bashore TM, et al. ACC\/AHA 2008 Guidelines for the Management of Adults with Congenital Heart Disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (writing committee to develop guidelines on the management of adults with congenital heart disease). Circulation 2008; 118: e714-833.","journal-title":"Circulation"},{"key":"ref-1142897","first-page":"e698","article-title":"AHA\/ACC Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"139","author":"Stout KK","year":"2019","unstructured":"Stout KK, Daniels CJ, Aboulhosn JA, et al. 2018 AHA\/ACC Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 2019; 139: e698-e800.","journal-title":"Circulation"},{"key":"ref-1142898","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1016\/S0828-282X(10)70355-X","article-title":"Canadian Cardiovascular Society 2009 Consensus Conference on the management of adults with congenital heart disease: outflow tract obstruction, coarctation of the aorta, tetralogy of Fallot, Ebstein anomaly and Marfan\u2019s syndrome","volume":"26","author":"Silversides CK","year":"2010","unstructured":"Silversides CK, Kiess M, Beauchesne L, et al. Canadian Cardiovascular Society 2009 Consensus Conference on the management of adults with congenital heart disease: outflow tract obstruction, coarctation of the aorta, tetralogy of Fallot, Ebstein anomaly and Marfan\u2019s syndrome. Can J Cardiol 2010; 26: e80-97.","journal-title":"Can J Cardiol"},{"key":"ref-1142899","first-page":"2915","article-title":"ESC Guidelines for the management of grown-up congenital heart disease (new version 2010): The Task Force on the Management of Grown-up Congenital Heart Disease of the European Society of Cardiology (ESC)","author":"Baumgartner H","unstructured":"Baumgartner H, Bonhoeffer P, De Groot NM, et al. ESC Guidelines for the management of grown-up congenital heart disease (new version 2010): The Task Force on the Management of Grown-up Congenital Heart Disease of the European Society of Cardiology (ESC). Endorsed by the Association for European Paediatric Cardiology (AEPC). Eur Heart J 2010; 31: 2915-2957.","journal-title":"Endorsed by the Association for European Paediatric Cardiology (AEPC)"},{"key":"ref-1142900","first-page":"934","article-title":"Range of ventricular dimensions and function by steady-state free precession cine MRI in repaired tetralogy of Fallot: right ventricular outflow tract patch vs","author":"Samyn MM","unstructured":"Samyn MM, Powell AJ, Garg R, et al. Range of ventricular dimensions and function by steady-state free precession cine MRI in repaired tetralogy of Fallot: right ventricular outflow tract patch vs. conduit repair. J Magn Reson Imaging 2007; 26: 934-940.","journal-title":"conduit repair"},{"key":"ref-1142901","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0140-6736(00)02714-8","article-title":"Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: a multicentre study","volume":"356","author":"Gatzoulis MA","year":"2000","unstructured":"Gatzoulis MA, Balaji S, Webber SA, et al. Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: a multicentre study. Lancet 2000; 356: 975-981.","journal-title":"Lancet"},{"key":"ref-1142902","first-page":"2257","article-title":"Pulmonary regurgitation in the late postoperative follow-up of tetralogy of Fallot","author":"Rebergen S","unstructured":"Rebergen S, Chin J, Ottenkamp J, et al. Pulmonary regurgitation in the late postoperative follow-up of tetralogy of Fallot. Volumetric quantitation by nuclear magnetic resonance velocity mapping. Circulation 1993; 88: 2257-2266.","journal-title":"Volumetric quantitation by nuclear magnetic resonance velocity mapping"},{"key":"ref-1142903","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1136\/heart.88.5.510","article-title":"Influence of the pulmonary annulus diameter on pulmonary regurgitation and right ventricular pressure load after repair of tetralogy of Fallot","volume":"88","author":"Uebing A","year":"2002","unstructured":"Uebing A, Fischer G, Bethge M, et al. Influence of the pulmonary annulus diameter on pulmonary regurgitation and right ventricular pressure load after repair of tetralogy of Fallot. Heart 2002; 88: 510-514.","journal-title":"Heart"},{"key":"ref-1142904","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.athoracsur.2006.03.038","article-title":"Brain natriuretic peptide and magnetic resonance imaging in tetralogy with right ventricular dilatation","volume":"82","author":"Dodge-Khatami A","year":"2006","unstructured":"Dodge-Khatami A, Buchel EV, Knirsch W, et al. Brain natriuretic peptide and magnetic resonance imaging in tetralogy with right ventricular dilatation. Ann Thorac Surg 2006; 82: 983-988.","journal-title":"Ann Thorac Surg"},{"key":"ref-1142905","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.amjcard.2005.10.047","article-title":"Effects of volume and\/or pressure overload secondary to congenital heart disease (tetralogy of Fallot or pulmonary stenosis) on right ventricular function using cardiovascular magnetic resonance and B-type natriuretic peptide levels","volume":"97","author":"Oosterhof T","year":"2006","unstructured":"Oosterhof T, Tulevski II, Vliegen HW, et al. Effects of volume and\/or pressure overload secondary to congenital heart disease (tetralogy of Fallot or pulmonary stenosis) on right ventricular function using cardiovascular magnetic resonance and B-type natriuretic peptide levels. Am J Cardiol 2006; 97: 1051-1055.","journal-title":"Am J Cardiol"},{"key":"ref-1142906","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/S0735-1097(02)02566-4","article-title":"Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction","volume":"40","author":"Davlouros PA","year":"2002","unstructured":"Davlouros PA, Kilner PJ, Hornung TS, et al. Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction. J Am Coll Cardiol 2002; 40: 2044-2052.","journal-title":"J Am Coll Cardiol"},{"key":"ref-1142907","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.jacc.2003.10.045","article-title":"Factors associated with impaired clinical status in long-term survivors of tetralogy of Fallot repair evaluated by magnetic resonance imaging","volume":"43","author":"Geva T","year":"2004","unstructured":"Geva T, Sandweiss BM, Gauvreau K, et al. Factors associated with impaired clinical status in long-term survivors of tetralogy of Fallot repair evaluated by magnetic resonance imaging. J Am Coll Cardiol 2004; 43: 1068-1074.","journal-title":"J Am Coll Cardiol"},{"key":"ref-1142908","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/eurheartj\/ehn595","article-title":"Refining the assessment of pulmonary regurgitation in adults after tetralogy of Fallot repair: should we be measuring regurgitant fraction or regurgitant volume?","volume":"30","author":"Wald RM","year":"2009","unstructured":"Wald RM, Redington AN, Pereira A, et al. Refining the assessment of pulmonary regurgitation in adults after tetralogy of Fallot repair: should we be measuring regurgitant fraction or regurgitant volume? Eur Heart J 2009; 30: 356-361.","journal-title":"Eur Heart J"},{"key":"ref-1142909","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1016\/j.ejrad.2010.07.009","article-title":"Quantitative assessment of pulmonary regurgitation in patients with and without right ventricular outflow tract obstruction","volume":"80","author":"Spiewak M","year":"2011","unstructured":"Spiewak M, Biernacka EK, Ma\u0142ek LA, et al. Quantitative assessment of pulmonary regurgitation in patients with and without right ventricular outflow tract obstruction. Eur J Radiol 2011; 80: e164-168.","journal-title":"Eur J Radiol"},{"key":"ref-1142910","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/eurheartj\/ehp586","article-title":"Recommendations for cardiovascular magnetic resonance in adults with congenital heart disease from the respective working groups of the European Society of Cardiology","volume":"31","author":"Kilner PJ","year":"2010","unstructured":"Kilner PJ, Geva T, Kaemmerer H, et al. Recommendations for cardiovascular magnetic resonance in adults with congenital heart disease from the respective working groups of the European Society of Cardiology. Eur Heart J 2010; 31: 794-805.","journal-title":"Eur Heart J"},{"key":"ref-1142911","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10554-009-9501-y","article-title":"Intra-observer and interobserver variability of biventricular function, volumes and mass in patients with congenital heart disease measured by CMR imaging","volume":"26","author":"Luijnenburg SE","year":"2010","unstructured":"Luijnenburg SE, Robbers-Visser D, Moelker A, et al. Intra-observer and interobserver variability of biventricular function, volumes and mass in patients with congenital heart disease measured by CMR imaging. Int J Cardiovasc Imaging 2010; 26: 57-64.","journal-title":"Int J Cardiovasc Imaging"},{"key":"ref-1142912","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1056\/NEJM199308263290901","article-title":"Long-term outcome in patients undergoing surgical repair of tetralogy of Fallot","volume":"329","author":"Murphy JG","year":"1993","unstructured":"Murphy JG, Gersh BJ, Mair DD, et al. Long-term outcome in patients undergoing surgical repair of tetralogy of Fallot. N Engl J Med 1993; 329: 593-599.","journal-title":"N Engl J Med"},{"key":"ref-1142913","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1055\/s-2007-1013719","article-title":"Long-term results of total repair of tetralogy of Fallot in adulthood: 35 years follow-up in 104 patients corrected at the age of 18 or older","volume":"45","author":"Nollert G","year":"1997","unstructured":"Nollert G, Fischlein T, Bouterwek S, et al. Long-term results of total repair of tetralogy of Fallot in adulthood: 35 years follow-up in 104 patients corrected at the age of 18 or older. Thorac Cardiovasc Surg 1997; 45: 178-181.","journal-title":"Thorac Cardiovasc Surg"},{"key":"ref-1142914","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0022-5223(20)31435-5","article-title":"Prevalence and risk factors of tricuspid regurgitation after correction of tetralogy of Fallot","volume":"102","author":"Kobayashi J","year":"1991","unstructured":"Kobayashi J, Kawashima Y, Matsuda H, et al. Prevalence and risk factors of tricuspid regurgitation after correction of tetralogy of Fallot. J Thorac Cardiovasc Surg 1991; 102: 611-616.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref-1142915","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/jmri.22532","article-title":"Right ventricular outflow tract obstruction as a confounding factor in the assessment of the impact of pulmonary regurgitation on the right ventricular size and function in patients after repair of tetralogy of Fallot","volume":"33","author":"Spiewak M","year":"2011","unstructured":"Spiewak M, Biernacka EK, Ma\u0142ek LA, et al. Right ventricular outflow tract obstruction as a confounding factor in the assessment of the impact of pulmonary regurgitation on the right ventricular size and function in patients after repair of tetralogy of Fallot. J Magn Reson Imaging 2011; 33: 1040-1046.","journal-title":"J Magn Reson Imaging"},{"key":"ref-1142916","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.amjcard.2007.06.038","article-title":"Cardiac magnetic resonance imaging correlates of exercise capacity in patients with surgically repaired tetralogy of Fallot","volume":"100","author":"Meadows J","year":"2007","unstructured":"Meadows J, Powell AJ, Geva T, et al. Cardiac magnetic resonance imaging correlates of exercise capacity in patients with surgically repaired tetralogy of Fallot. Am J Cardiol 2007; 100: 1446-1450.","journal-title":"Am J Cardiol"},{"key":"ref-1142917","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.amjcard.2004.11.037","article-title":"Optimal timing for pulmonary valve replacement in adults after tetralogy of Fallot repair","volume":"95","author":"Therrien J","year":"2005","unstructured":"Therrien J, Provost Y, Merchant N, Williams W, Colman J, Webb G. Optimal timing for pulmonary valve replacement in adults after tetralogy of Fallot repair. Am J Cardiol 2005; 95: 779-782.","journal-title":"Am J Cardiol"},{"key":"ref-1142918","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1148\/radiol.12120051","article-title":"Repaired tetralogy of Fallot: ratio of right ventricular volume to left ventricular volume as a marker of right ventricular dilatation","volume":"265","author":"Spiewak M","year":"2012","unstructured":"Spiewak M, Ma\u0142ek \u0141A, Petryka J, et al. Repaired tetralogy of Fallot: ratio of right ventricular volume to left ventricular volume as a marker of right ventricular dilatation. Radiology 2012; 265: 78-86.","journal-title":"Radiology"},{"key":"ref-1142919","first-page":"1","article-title":"Non-invasive estimation of pulmonary outflow tract obstruction: a comparative study of cardiovascular phase contrast magnetic resonance and Doppler echocardiography versus cardiac catheterization","volume":"10","author":"Kowallick JT","year":"2015","unstructured":"Kowallick JT, Steinmetz M, Schuster A, et al. Non-invasive estimation of pulmonary outflow tract obstruction: a comparative study of cardiovascular phase contrast magnetic resonance and Doppler echocardiography versus cardiac catheterization. Int J Cardiol Heart Vasc 2015; 10: 1-7.","journal-title":"Int J Cardiol Heart Vasc"},{"key":"ref-1142920","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3109\/10976640009148691","article-title":"Reduction in sample size for studies of remodeling in heart failure by the use of cardiovascular magnetic resonance","volume":"2","author":"Bellenger NG","year":"2000","unstructured":"Bellenger NG, Davies LC, Francis JM, et al. Reduction in sample size for studies of remodeling in heart failure by the use of cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2000; 2: 271-278.","journal-title":"J Cardiovasc Magn Reson"},{"key":"ref-1142921","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/jmri.1052","article-title":"Measurement of left ventricular dimensions and function in patients with dilated cardiomyopathy","volume":"13","author":"Strohm O","year":"2001","unstructured":"Strohm O, Schulz-Menger J, Pilz B, et al. Measurement of left ventricular dimensions and function in patients with dilated cardiomyopathy. J Magn Reson Imaging 2001; 13: 367-371.","journal-title":"J Magn Reson Imaging"},{"key":"ref-1142922","doi-asserted-by":"crossref","first-page":"e511","DOI":"10.5114\/pjr.2019.91203","article-title":"Multi-detector computed tomography angiographic evaluation of right ventricular outflow tract obstruction and other associated cardiovascular anomalies in tetralogy of Fallot patients","volume":"84","author":"Singh RK","year":"2019","unstructured":"Singh RK, Jain N, Kumar S, Garg N. Multi-detector computed tomography angiographic evaluation of right ventricular outflow tract obstruction and other associated cardiovascular anomalies in tetralogy of Fallot patients. Pol J Radiol 2019; 84: e511-e516.","journal-title":"Pol J Radiol"}],"container-title":["Polish Journal of Radiology"],"original-title":[],"link":[{"URL":"https:\/\/www.polradiol.com\/pdf-122794-108810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polradiol.com\/pdf-122794-108810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T07:33:46Z","timestamp":1716363226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polradiol.com\/The-impact-of-pulmonary-regurgitation-on-right-ventricular-size-and-function-in-patients,122794,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,3]]},"references-count":27,"alternative-id":["122794"],"URL":"https:\/\/doi.org\/10.5114\/pjr.2020.101058","relation":{},"ISSN":["1899-0967"],"issn-type":[{"value":"1899-0967","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,3]]}}}