{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:39:54Z","timestamp":1790397594011,"version":"4.1.0"},"reference-count":20,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Radiol"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study was designed to investigate mandibular lesions using volumetric analysis with bone single-photon emission computed tomography\/computed tomography (SPECT\/CT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Eight patients with mandibular lesions underwent SPECT\/CT scan acquisition 4 hours after injection of Tc-99m hydroxymethylene diphosphonate (HMDP). Regarding volumetric analysis, maximum standar\u00addized uptake value (SUV) was obtained using software and a\u00a0workstation (Q.Volumetrix MI and GEniE-Xeleris 4 DR, respectively). The localization and size of the volume of interest (VOI) can be drawn over the lesion, mesial, distal, and opposite side as normal using the CT, SPECT, and SPECT\/CT transaxials, coronals, and sagittals as the anatomical reference. Q.Volumetrix MI can analyse SUV of lesions by organ segmentation using optional pan and zoom imaging. Then, the dosimetry software provided multiple quantitative data for a\u00a0given VOI. Statistical analyses for the maximum SUV were performed by Mann-Whitney U\u00a0test. A\u00a0p-value lower than 0.05 was considered as statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maximum SUVs for medication-related osteonecrosis of the jaw (n = 4, 25.4 \u00b1 4.9), chronic osteomyelitis (n = 3, 14.6 \u00b1 3.1), and squamous cell carcinoma (n = 1, 31.7) were significantly higher than those of the opposite side as normal mandible (3.8 \u00b1 0.7, 4.6 \u00b1 1.8, and 7.4, respectively; p = 0.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Volumetric analysis with SPECT\/CT could be useful for the evaluation of mandibular lesions, such as detecting and surgical planning.<\/jats:p><\/jats:sec>","DOI":"10.5114\/pjr.2022.117569","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T06:54:47Z","timestamp":1657608887000},"page":"311-315","source":"Crossref","is-referenced-by-count":7,"title":["Volumetric analysis of mandibular lesions with SPECT\/CT: a pilot clinical study of maximum standardized uptake value"],"prefix":"10.5114","volume":"87","author":[{"given":"Yoshiyuki","family":"Minami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruri","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"ref-1154013","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1148\/radiol.2016152294","article-title":"Maximum standardized uptake value of 99mTc hydroxymethylene diphosphonate SPECT\/CT for the evaluation of temporomandibular joint disorder","volume":"280","author":"Suh MS","year":"2016","unstructured":"Suh MS, Lee WW, Kim YK, et al. Maximum standardized uptake value of 99mTc hydroxymethylene diphosphonate SPECT\/CT for the evaluation of temporomandibular joint disorder. Radiology 2016; 280: 890-896.","journal-title":"Radiology"},{"key":"ref-1154014","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1007\/s00784-019-02862-8","article-title":"Comparative evaluation of SPECT\/CT and CBCT in patients with mandibular osteomyelitis and osteonecrosis","volume":"23","author":"Malina-Altzinger J","year":"2019","unstructured":"Malina-Altzinger J, Klaeser B, Suter VGA, et al. Comparative evaluation of SPECT\/CT and CBCT in patients with mandibular osteomyelitis and osteonecrosis. Clin Oral Investig 2019; 23: 4213-4222.","journal-title":"Clin Oral Investig"},{"key":"ref-1154015","doi-asserted-by":"crossref","first-page":"108917","DOI":"10.1016\/j.ejrad.2020.108917","article-title":"Evaluation of SPECT\/CT in the assessment of inflammatory jaw pathologies","volume":"125","author":"Modabber A","year":"2020","unstructured":"Modabber A, Schick D, M\u00f6hlhenrich SC, et al. Evaluation of SPECT\/CT in the assessment of inflammatory jaw pathologies. Eur J Radiol 2020; 125: 108917.","journal-title":"Eur J Radiol"},{"key":"ref-1154016","doi-asserted-by":"crossref","first-page":"20200516","DOI":"10.1259\/dmfr.20200516","article-title":"Analysis of medication-related osteonecrosis of the jaw with bone SPECT\/CT: relationship between patient characteristics and maximum standardized uptake value","volume":"50","author":"Ogawa R","year":"2021","unstructured":"Ogawa R, Ogura I. Analysis of medication-related osteonecrosis of the jaw with bone SPECT\/CT: relationship between patient characteristics and maximum standardized uptake value. Dentomaxillofac Radiol 2021; 50: 20200516.","journal-title":"Dentomaxillofac Radiol"},{"key":"ref-1154017","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jcms.2019.03.013","article-title":"Clinical value of 3D SPECT\/CT imaging for assessing jaw bone invasion in oral cancer patients","volume":"47","author":"Miyashita H","year":"2019","unstructured":"Miyashita H, Nakahara T, Asoda S, et al. Clinical value of 3D SPECT\/CT imaging for assessing jaw bone invasion in oral cancer patients. J Craniomaxillofac Surg 2019; 47: 1139-1146.","journal-title":"J Craniomaxillofac Surg"},{"key":"ref-1154018","doi-asserted-by":"crossref","first-page":"20190208","DOI":"10.1259\/dmfr.20190208","article-title":"Three-dimensional radiologic-pathologic correlation of medication-related osteonecrosis of the jaw using 3D bone SPECT\/CT imaging","volume":"48","author":"Miyashita H","year":"2019","unstructured":"Miyashita H, Kameyama K, Morita M, et al. Three-dimensional radiologic-pathologic correlation of medication-related osteonecrosis of the jaw using 3D bone SPECT\/CT imaging. Dentomaxillofac Radiol 2019; 48: 20190208.","journal-title":"Dentomaxillofac Radiol"},{"key":"ref-1154019","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.clinimag.2018.06.009","article-title":"Semiquantitative analysis using standardized uptake value in 123I-FP-CIT SPECT\/CT","volume":"52","author":"Toriihara A","year":"2018","unstructured":"Toriihara A, Daisaki H, Yamaguchi A, et al. Semiquantitative analysis using standardized uptake value in 123I-FP-CIT SPECT\/CT. Clin Imaging 2018; 52: 57-61.","journal-title":"Clin Imaging"},{"key":"ref-1154020","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12149-019-01425-x","article-title":"Quantification evaluation of 99mTc-MDP concentration in the lumbar spine with SPECT\/CT: compare with bone mineral density","volume":"34","author":"Huang K","year":"2020","unstructured":"Huang K, Feng Y, Liu D, et al. Quantification evaluation of 99mTc-MDP concentration in the lumbar spine with SPECT\/CT: compare with bone mineral density. 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