{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T21:08:34Z","timestamp":1773436114352,"version":"3.50.1"},"reference-count":31,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Radiol"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Primary hyperparathyroidism is mainly caused by parathyroid adenomas. Preoperative imaging can be performed using different imaging modalities, e.g. ultrasound (US), radionuclide scanning, magnetic resonance imaging, and computed tomography, often used in combination. Currently, US-guided blue dyes, especially methylene blue (MB) injection, are used to identify parathyroid tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This was a retrospective study of 228 patients. Preoperative ultrasound, scintigraphy, and bio\u00adchemistry were performed on all patients, and fine-needle aspiration procedures were performed on suspected patients. Using preoperative US-G injection with MB dye, target tumours were injected in all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 163 patients were female and 65 were male. The mean age was 42.5 years. US was positive in 203 (89%) cases, 25 (11%) were negative, and all had a positive sestamibi scan (100%). US-G needle injections with MB dye of target tumours were successful in all cases. The average diameter of the lesions was 18 mm. All had positive intraoperative identification of parathyroid adenoma and MB staining (100% accuracy, 100% sensitivity, and 100% specificity). Operating time (min \u00b1 SD) was 22.7 \u00b1 11.5 minutes, and the success rate was 100%. All were parathyroid adenomas histologically. Intraoperative parathormone hormone decreased in all patients. In postoperative follow-up, all were normocalcaemic with no local or systemic complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Localisation of small parathyroid adenomas by US-guided blue dye injection is a safe, simple, and useful tool when performing parathyroidectomy with no complications.<\/jats:p><\/jats:sec>","DOI":"10.5114\/pjr.2024.136402","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T09:39:34Z","timestamp":1710841174000},"page":"134-139","source":"Crossref","is-referenced-by-count":2,"title":["Preoperative localisation of parathyroid adenomas using ultrasound-guided methylene blue dye injection"],"prefix":"10.5114","volume":"89","author":[{"given":"Mohamed M.","family":"Harraz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed H.","family":"Abouissa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Ibrahim","family":"Tawfik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Monir","family":"Eltantawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"ref-1161291","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/jso.20873","article-title":"Radio-guided nonpalpable metastatic lymph node localization in patients with recurrent thyroid cancer","volume":"96","author":"T\u00fckenmez M","year":"2007","unstructured":"T\u00fckenmez M, Erbil Y, Barbaros U, et al. 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Br Med J 1971; 3: 680-681.","journal-title":"Br Med J"},{"key":"ref-1161294","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1210\/jc.2006-0386","article-title":"Hook needle-guided excision of recurrent differentiated thyroid cancer in previously operated neck compartments: a safe technique for small, nonpalpable recurrent disease","volume":"91","author":"Triponez F","year":"2006","unstructured":"Triponez F, Poder L, Zarnegar R, et al. Hook needle-guided excision of recurrent differentiated thyroid cancer in previously operated neck compartments: a safe technique for small, nonpalpable recurrent disease. 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Intraoperative guidance in parathyroid surgery using near-infrared fluorescence imaging and low-dose Methylene Blue. Surgery 2015; 158: 1323-1330.","journal-title":"Surgery"},{"key":"ref-1161297","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00268-008-9797-0","article-title":"Localization of recurrent thyroid cancer using intraoperative ultrasound-guided dye injection","volume":"33","author":"Sippel RS","year":"2009","unstructured":"Sippel RS, Elaraj DM, Poder L, et al. Localization of recurrent thyroid cancer using intraoperative ultrasound-guided dye injection. World J Surg 2009; 33: 434-439.","journal-title":"World J Surg"},{"key":"ref-1161298","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/bjs.5574","article-title":"Minimally invasive parathyroidectomy without intraoperative monitoring in patients with primary hyperparathyroidism","volume":"94","author":"Mihai R","year":"2007","unstructured":"Mihai R, Palazzo F, Gleeson FV, et al. Minimally invasive parathyroidectomy without intraoperative monitoring in patients with primary hyperparathyroidism. Br J Surg 2007; 94: 42-47.","journal-title":"Br J Surg"},{"key":"ref-1161299","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/BF01665301","article-title":"Surgical treatment of primary hyperparathyroidism: an institutional perspective","volume":"15","author":"van Heerden JA","year":"1991","unstructured":"van Heerden JA, Grant CS. Surgical treatment of primary hyperparathyroidism: an institutional perspective. 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World J Surg 2009; 33: 434-439.","journal-title":"World J Surg"},{"key":"ref-1161308","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1002\/lary.23863","article-title":"The diagnostic value of parathyroid hormone washout after fine-needle aspiration of suspicious cervical lesions in patients with hyperparathyroidism","volume":"123","author":"Abdelghani R","year":"2013","unstructured":"Abdelghani R, Noureldine S, Abbas A, et al. The diagnostic value of parathyroid hormone washout after fine-needle aspiration of suspicious cervical lesions in patients with hyperparathyroidism. Laryngoscope 2013; 123: 1310-1313.","journal-title":"Laryngoscope"},{"key":"ref-1161309","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/BF01655524","article-title":"Clinical management of persistent and\/or recurrent primary hyperparathyroidism","volume":"10","author":"Grant CS","year":"1986","unstructured":"Grant CS, van Heerden JA, Charboneau JW, et al. 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Institutional experience of PTH evaluation on fine-needle washouting after aspiration biopsy to locate hyperfunctioning parathyroid tissue. J Zhejiang Univ Sci B 2009; 10: 323-330.","journal-title":"J Zhejiang Univ Sci B"},{"issue":"11 Pt 1","key":"ref-1161316","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1097\/00005537-200111000-00005","article-title":"Methylene blue and sestamibi: complementary tools for localizing parathyroids","volume":"111","author":"Orloff LA","year":"2001","unstructured":"Orloff LA. Methylene blue and sestamibi: complementary tools for localizing parathyroids. Laryngoscope 2001; 111 (11 Pt 1): 1901-1904.","journal-title":"Laryngoscope"},{"key":"ref-1161317","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1677\/erc.0.0080063","article-title":"Localization of parathyroid tumors in the minimally invasive era: which technique should be chosen? 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Acta Radiol 1996; 37: 720-726.","journal-title":"Acta Radiol"},{"key":"ref-1161319","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1148\/radiology.218.3.r01fe38783","article-title":"Comparison between MR imaging and 99mTc MIBI scintigraphy in the evaluation of recurrent persistent hyperparathyroidism","volume":"218","author":"Gotway MB","year":"2001","unstructured":"Gotway MB, Reddy GP, Webb WR, et al. Comparison between MR imaging and 99mTc MIBI scintigraphy in the evaluation of recurrent persistent hyperparathyroidism. Radiology 2001; 218: 783-790.","journal-title":"Radiology"},{"key":"ref-1161320","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s00268-003-6991-y","article-title":"Clinical value of parathyroid scintigraphy with technetium-99m methoxyiso-butylisonitrile discrepancies in clinical data and a systematic metaanalysis of the literature","volume":"28","author":"Gotthardt M","year":"2004","unstructured":"Gotthardt M, Lohmann B, Behr TM, et al. 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