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The novel experimental MMP-targeted treatments in OA and RA are MMP inhibitors eg. 3-B2, taraxasterol, and naringin. While other treatments aim to silence miRNAs, lncRNAs, or transcription factors. Additionally, other recent MMP-related developments include gene polymorphism of MMPs, which has been linked to OA susceptibility, and the MMP-generated neoepitope of CRP, which could serve as a biomarker of OA progression.<\/jats:p>","DOI":"10.5114\/reum\/168503","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T06:30:57Z","timestamp":1689748257000},"page":"191-201","source":"Crossref","is-referenced-by-count":63,"title":["Matrix metalloproteinases in rheumatoid arthritis and osteoarthritis: a state of the art review"],"prefix":"10.5114","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4953-0075","authenticated-orcid":false,"given":"\u0141ukasz","family":"Pulik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-5750","authenticated-orcid":false,"given":"Pawe\u0142","family":"\u0141\u0119gosz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Motyl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2023,7,2]]},"reference":[{"key":"ref-908481","unstructured":"What is arthritis \u2013 inflammatory diseases. 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