{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:54:07Z","timestamp":1787313247401,"version":"build-2736575974"},"reference-count":40,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The aims were to study the sociodemographic characteristics of patients presenting to the clinic and to study the clinical and serological pattern of systemic lupus erythematosus (SLE) in a new rheumatology clinic of a predominantly Yoruba population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>This was a retrospective, cross-sectional study conducted over 7 years (January 2017 \u2013 December 2023). Patients who satisfied the 1997 American College of Rheumatology (ACR) and\/or the 2012 Systemic Lupus International Collaborating Clinics (SLICC) classification criteria were enrolled using their medical records. Patients with overlap syndromes and other inflammatory or noninflammatory rheumatic diseases were excluded from the study. Their sociodemographic, clinical, laboratory, and treatment data were retrieved from their medical records and analysed using IBM SPSS version 23.0 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 65 patients were diagnosed with SLE with a frequency of 15.8%. The mean age \u00b1SD of the patients at presentation was 33.85 years \u00b111.01 and the female to male ratio was 9.8 : 1. The median (IQR) duration of symptoms at presentation was 7.0 months (3\u201324). The common clinical presentations included synovitis (86.2%), acute cutaneous rash (53.8%), oral ulcers (52.3%), nonscarring alopecia (50.8%), and serositis (47.7%). Proteinuria was seen in 37.7% of the patients and the predominant renal histopathological feature was Class IV. Antinuclear antibody was 100% positive with 50.94% of the patients having a titre of 1 : 5,120 and above. Anti- double-stranded deoxyribonucleic acid and anti-Smith antibodies each had 50% prevalence. Dyslipidaemia was found in 76.7% of the patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study\u2019s findings are largely consistent with similar studies done in Africa. Further prospective multi-centred studies are needed to further determine the epidemiological characteristics of the disease in Nigeria with a multi-ethnic population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/reum\/187208","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T10:05:29Z","timestamp":1715335529000},"page":"83-93","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and laboratory profiles of systemic lupus erythematosus patients in a new rheumatology clinic in southwestern Nigeria"],"prefix":"10.5114","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5995-5678","authenticated-orcid":false,"given":"Gbenga Joshua","family":"Odunlami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4431-2570","authenticated-orcid":false,"given":"Adeola","family":"Ajibade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolanle Aderonke","family":"Omotosho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-5241","authenticated-orcid":false,"given":"Muzamil Olamide","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeyemi Abiola","family":"Adefidipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2922-5038","authenticated-orcid":false,"given":"Fatai Olatunde","family":"Olanrewaju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademola Olusegun","family":"Enitan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4205-9399","authenticated-orcid":false,"given":"Tajudin Adesegun","family":"Adetunji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olumide Akinniyi","family":"Akinyele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluyomi","family":"Okunola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"ref-1176228","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.09.004"},{"key":"ref-1176229","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.11.001"},{"key":"ref-1176230","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex260"},{"key":"ref-1176231","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00668-1"},{"key":"ref-1176232","doi-asserted-by":"crossref","unstructured":"Lee YH, Choi SJ, Ji JD, Song GG. 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