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The\u00a0most common symptoms include joint pain, arthritis, tendinitis leading to tendon rupture, acro-osteolysis, calcinosis, myalgia, and myositis. Osteo-articular complications and changes in the\u00a0soft tissues of\u00a0the\u00a0hand lead to finger contracture, which causes deterioration of\u00a0the\u00a0patients\u2019 quality of\u00a0life and disability. To sum up, a\u00a0more detailed understanding of\u00a0the\u00a0aetiology leading to progressive changes in the\u00a0musculoskeletal system may contribute to the\u00a0introduction of\u00a0new therapeutic options, and thus improve the\u00a0quality of\u00a0life and reduce disability in patients with SSc.<\/jats:p>","DOI":"10.5114\/reum\/190576","type":"journal-article","created":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T15:14:00Z","timestamp":1723994040000},"source":"Crossref","is-referenced-by-count":1,"title":["Musculoskeletal involvement in systemic sclerosis"],"prefix":"10.5114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2193-7778","authenticated-orcid":false,"given":"Ewa","family":"Wielosz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9058-3172","authenticated-orcid":true,"given":"Marcin Grzegorz","family":"Hy\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2024,8,18]]},"reference":[{"key":"ref-1237496","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2023.01.008"},{"key":"ref-1237497","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2014.03.027"},{"key":"ref-1237498","doi-asserted-by":"publisher","DOI":"10.1177\/2397198318779532"},{"key":"ref-1237499","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.05.024"},{"key":"ref-1237500","doi-asserted-by":"publisher","DOI":"10.1177\/0394632015572750"},{"key":"ref-1237501","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4569826"},{"key":"ref-1237502","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14070669"},{"key":"ref-1237503","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.31.3.341"},{"key":"ref-1237504","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2013.10.003"},{"key":"ref-1237505","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2205-3"},{"key":"ref-1237506","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2019.11.003"},{"key":"ref-1237507","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-004-0830-6"},{"key":"ref-1237508","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq310"},{"key":"ref-1237509","doi-asserted-by":"publisher","DOI":"10.1136\/ard.41.2.147"},{"key":"ref-1237510","doi-asserted-by":"publisher","DOI":"10.1136\/ard.41.2.147"},{"key":"ref-1237511","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.044602"},{"key":"ref-1237512","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken179"},{"key":"ref-1237513","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091165"},{"key":"ref-1237514","unstructured":"B\u00e1lint Z, Farkas H, Farkas N, et al. 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