{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:57:16Z","timestamp":1785473836456,"version":"3.56.0"},"reference-count":35,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"abstract":"Introduction<\/jats:title>Psoriatic arthritis (PsA) is a heterogeneous disease with various manifestations such as dactylitis, enthesitis, spondylitis, and skin involvement. Minimal disease activity (MDA) has been successfully used in daily clinical practice and is considered a reasonable treatment target in patients with PsA. In this study, we aimed to evaluate the MDA status and associated factors in patients with PsA in our tertiary referral clinic.<\/jats:p><\/jats:sec>Material and methods<\/jats:title>This cross-sectional study included patients who met the CASPAR classification criteria and had at least 6 months of follow-up data between 2001 and 2021. Patients who met at least 5 of 7 criteria (tender joint count \u2264 1\/68, swollen joint count \u2264 1\/66, Psoriasis Area Severity Index [PASI] \u2264 1, Visual Analogue Scale [VAS] \u2264 15, patient global VAS \u2264 20, Health Assessment Questionnaire-Disability Index [HAQ-DI] \u2264 0.5, and enthesitis number \u2264 1) were considered to achieve MDA.<\/jats:p><\/jats:sec>Results<\/jats:title>Data from 172 patients (61% female) were analyzed and included in the study. While most patients had polyarticular involvement (33.7%), mono-oligoarthritis was present in 30.2%, mixed type in 26.2%, isolated distal interphalangeal arthritis in 5.8%, isolated spondylitis in 2.9%, and arthritis mutilans in 1.2%. Overall, 95 (55.2%) of the patients were observed at MDA, which was lower in tumor necrosis factor inhibitor (TNFi) users compared to only conventional synthetic disease-modifying antirheumatic drug users. In univariate analysis, MDA was associated with higher patient age, longer psoriasis duration, late-onset PsA, and continued use of first TNFi. In multivariate analysis, higher patient age, late-onset PsA, and higher continuation rate of first TNFi were associated with MDA.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In the study, more than half of our patients achieved MDA status. A higher MDA rate was associated with a higher continuation rate at first-line TNFi treatment. The relatively large po\u00adpulation who could not reach MDA status in our study indicates an unmet need for monitoring and treatment of PsA.<\/jats:p><\/jats:sec>","DOI":"10.5114\/reum\/194595","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T12:56:02Z","timestamp":1730897762000},"source":"Crossref","is-referenced-by-count":1,"title":["Minimal disease activity and associated factors in patients with psoriatic arthritis: cross-sectional study from a single center"],"prefix":"10.5114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-3837","authenticated-orcid":true,"given":"Murat","family":"Bektas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berk","family":"\u00c7elik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9813-2228","authenticated-orcid":false,"given":"Burak","family":"\u0130nce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9357-0456","authenticated-orcid":false,"given":"Yasemin","family":"Yal\u00e7\u0131nkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5659-3955","authenticated-orcid":false,"given":"Bahar Art\u0131m","family":"Esen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8219-3720","authenticated-orcid":false,"given":"Ahmet","family":"G\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6376-5583","authenticated-orcid":false,"given":"Murat","family":"\u0130nan\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"ref-1284049","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2012.09.003"},{"key":"ref-1284050","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160861"},{"key":"ref-1284051","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13306"},{"key":"ref-1284052","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.08.004"},{"key":"ref-1284053","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.129379"},{"key":"ref-1284054","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24046"},{"key":"ref-1284055","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.094946"},{"key":"ref-1284056","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.102053"},{"key":"ref-1284057","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2017-000638"},{"key":"ref-1284058","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23537"},{"key":"ref-1284059","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23337"},{"key":"ref-1284060","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150995"},{"key":"ref-1284061","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key417"},{"key":"ref-1284062","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2016.1220809"},{"key":"ref-1284063","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"ref-1284064","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20155"},{"key":"ref-1284065","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120970"},{"key":"ref-1284066","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203696"},{"key":"ref-1284067","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22576"},{"key":"ref-1284068","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201972"},{"key":"ref-1284069","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew375"},{"key":"ref-1284070","unstructured":"Bakirci S, Solmaz D, Al Osaimi N, et al. 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