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The inflammatory processes occurring in the intestines may lead to disruption of tight junctions and increased concentrations of pro-inflammatory cytokines, resulting in increased permeability of intestines, causing low-grade inflammation, including in the joints. Methods of altering the GMB composition to reduce the inflammatory and joint dege\u00adnerative processes are known only to some extent, and long-term research is required. \nOsteoarthritis, a particularly well-known and very widespread disease due to the aging population, is characterized by moderate and local inflammation. It occurs due to the effects of biomechanical cartilage wear with damage of joint structures, primarily through degenerative processes. OA represents a therapeutic challenge, and any element that can influence its inhibition is highly sought after. Therefore, these methods seem to offer a promising additional approach to treatment.<\/jats:p>","DOI":"10.5114\/reum\/197061","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T09:18:07Z","timestamp":1739438287000},"source":"Crossref","is-referenced-by-count":0,"title":["The gut microbiome and osteoarthritis"],"prefix":"10.5114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2369-2396","authenticated-orcid":true,"given":"Wiktoria Maria","family":"Krupka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9311-6748","authenticated-orcid":false,"given":"Gabriela","family":"Motyl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3884-6883","authenticated-orcid":false,"given":"Joanna","family":"Dmowska-Chalaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"ref-1385771","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.12.007"},{"key":"ref-1385772","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00163-7"},{"key":"ref-1385773","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-022-00226-9"},{"key":"ref-1385774","unstructured":"Man G, Mologhianu G. 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