{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:53:14Z","timestamp":1792000394448,"version":"4.4.0"},"reference-count":19,"publisher":"Termedia Sp. z.o.o.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Beh\u00e7et\u2019s disease (BD) presents with highly variable clinical manifestations and a\u00a0hete\u00adrogeneous pattern of\u00a0symptom development. This study aimed to assess the\u00a0chronology of\u00a0symptom onset and clinical findings in BD patients at a\u00a0nationally recognized Beh\u00e7et\u2019s referral center and to examine associations between symptom progression and patient- and disease-related characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>A\u00a0retrospective review of\u00a0BD patients from a\u00a0national referral center in Iran was conducted between March 2007 and March 2017. Patients with \u2265 2 years of\u00a0follow-up were included. Demographic data, clinical characteristics, and laboratory findings were extracted. The\u00a0initial symptom and the\u00a0sequence of\u00a0symptom development were analyzed. The\u00a0time between symptom onset and diagnosis was recorded, and comparisons were made based on sex, age, human leukocyte antigen (HLA) type, and initial presenting symptom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A\u00a0total of\u00a02,615 patients (58.7% male) were included. The\u00a0mean age at BD diagnosis was 25.0 \u00b110.1 years, with a\u00a0median follow-up of\u00a026 years. Oral ulcers were the\u00a0most common manifestation (98.9% overall) and the\u00a0most frequent initial symptom (90.3%). Genital ulcers were observed in 61.3% of\u00a0patients, with a\u00a0mean onset 4.6 \u00b15.7 years after diagnosis. Ocular and vascular manifestations had the\u00a0longest latency from diagnosis. Male patients had a\u00a0shorter time to onset of\u00a0oral ulcers (p\u00a0=\u00a00.04) and ocular lesions (p\u00a0=\u00a00.04). Age correlated inversely with the\u00a0time to onset of\u00a0genital ulcers, skin, ocular, and vascular manifestations (all p\u00a0&lt;\u00a00.001). The\u00a0HLA-B5\/B51 carriers exhibited an\u00a0earlier onset of\u00a0genital ulcers (p\u00a0=\u00a00.004) and skin manifestations (p\u00a0=\u00a00.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings highlight substantial temporal heterogeneity in BD symptom progression. While oral ulcers appear early, genital ulcers and skin manifestations tend to develop later, and ocular and vascular lesions exhibit the\u00a0longest delay. The\u00a0chronology of\u00a0symptom onset is significantly influenced by age, sex, HLA-B5\/B51 status, and initial presenting symptom. These findings underscore the\u00a0importance of\u00a0long-term follow-up in BD management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/reum\/202818","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T08:48:01Z","timestamp":1762850881000},"page":"296-303","source":"Crossref","is-referenced-by-count":2,"title":["Clinical features and chronology of clinical manifestations in Beh\u00e7et\u2019s disease: A cohort of 2615 patients"],"prefix":"10.5114","volume":"63","author":[{"given":"Shokufe","family":"Sadeghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Tahereh","family":"Faezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Haerian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Nejadhosseinian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0783-9207","authenticated-orcid":true,"given":"Azarakhsh","family":"Baghdadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Shahram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massoomeh","family":"Akhlaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Alikhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilava","family":"Hedayati Emam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereydoun","family":"Davatchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"ref-1592737","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.12.006"},{"key":"ref-1592738","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2012.723112"},{"key":"ref-1592739","doi-asserted-by":"crossref","unstructured":"Davatchi F, Chams-Davatchi C, Shams H, et al. Behcet\u2019s disease: epidemiology, clinical manifestations, and diagnosis. Expert Rev Clin Immunol 2017; 13: 57\u201365, DOI: 10.1080\/1744666X.2016.1205486.","DOI":"10.1080\/1744666X.2016.1205486"},{"key":"ref-1592741","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12107"},{"key":"ref-1592742","doi-asserted-by":"crossref","unstructured":"Criteria for diagnosis of\u00a0Beh\u00e7et\u2019s disease. International Study Group for Beh\u00e7et\u2019s Disease. Lancet 1990; 335: 1078\u20131080.","DOI":"10.1016\/0140-6736(90)92643-V"},{"key":"ref-1592743","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1430-6"},{"key":"ref-1592744","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.208"},{"key":"ref-1592745","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08116.x"},{"key":"ref-1592746","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2007.48.4.573"},{"key":"ref-1592747","doi-asserted-by":"crossref","unstructured":"Calamia KT, Wilson FC, Icen M, et al. 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Chronology of\u00a0Clinical Manifestations in Beh\u00e7et\u2019s Disease. In: Zouboulis CC (ed). Ada\u00admantiades-Beh\u00e7et\u2019s Disease. Advances in Experimental Medicine and Biology, vol 528. 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