{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T07:52:59Z","timestamp":1774597979188,"version":"3.50.1"},"reference-count":27,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is a\u00a0complex autoimmune disease with clinical and laboratory characteristics influenced by the\u00a0age of\u00a0onset. Despite its significance, data on late-onset SLE (Lo-SLE) compared to early-onset SLE (Eo-SLE) remain limited, particularly in the\u00a0Polish population. We investigated differences between Lo-SLE and Eo-SLE patients (using 50 years as a\u00a0cutoff), aiming to improve the\u00a0diagnosis and management of\u00a0SLE patients across different age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>We conducted a\u00a0retrospective analysis of\u00a0medical records from all SLE patients treated at the\u00a0University Hospital in Krakow, Poland, from 2012 to 2022. All included patients met the\u00a02019 European Alliance of\u00a0Associations for Rheumatology and American College of\u00a0Rheumatology classification criteria for SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analyzed 710 patients with Eo-SLE (77.9%) and 201 patients with Lo-SLE (22.1%). Compared to the\u00a0Eo-SLE group, the\u00a0Lo-SLE group exhibited shorter disease duration (p &lt; 0.001), a\u00a0higher mortality rate (p &lt; 0.001), and distinct clinical features: less involvement of\u00a0the\u00a0central nervous system (n = 5, 2.5% vs. n = 51, 7.23%, p = 0.014) and kidney (n = 49, 24.38% vs. n = 294, 41.41%, p &lt; 0.001), more frequent interstitial lung disease (n = 19, 9.45% vs. n = 27, 3.84%, p = 0.001), and a\u00a0higher prevalence of\u00a0cardiovascular, metabolic, and neoplastic comorbidities (p &lt; 0.05, for all). Autoantibody profiles also differed: in Lo-SLE compared to Eo-SLE patients, anti-SSB were more common, while anti-histone, anti-nucleosome, anti-RNP, and anti-dsDNA antibodies were less pre\u00advalent. Late-onset SLE patients received immunosuppressive treatment less often than Eo-SLE patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Late-onset SLE patients exhibit different disease manifestations but with a\u00a0higher prevalence of\u00a0interstitial lung disease, internal medicine comorbidities, malignancies, and cardiovascular events compared to Eo-SLE. Our findings highlight the\u00a0need for tailored management stra\u00adtegies in elderly SLE patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/reum\/208170","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T07:01:39Z","timestamp":1774594899000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical and laboratory differences in characteristics of\u00a0patients with early-onset and late-onset systemic lupus erythematosus: a\u00a0single-center retrospective study"],"prefix":"10.5114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0321-3557","authenticated-orcid":true,"given":"Rados\u0142aw","family":"Dziedzic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2221-614X","authenticated-orcid":false,"given":"Lech","family":"Zar\u0119ba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-0248","authenticated-orcid":false,"given":"And\u017celika","family":"Siwiec-Ko\u017alik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2209-1436","authenticated-orcid":false,"given":"Magdalena","family":"Spa\u0142kowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6492-6521","authenticated-orcid":false,"given":"Agnieszka","family":"Padjas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9634-0963","authenticated-orcid":false,"given":"Stanis\u0142awa","family":"Bazan-Socha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1749-9739","authenticated-orcid":true,"given":"Mariusz","family":"Korkosz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1013-2253","authenticated-orcid":true,"given":"Joanna","family":"Kosa\u0142ka-W\u0119giel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"ref-1725676","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)-00398-2"},{"key":"ref-1725677","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60128-8"},{"key":"ref-1725678","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.16810"},{"key":"ref-1725679","doi-asserted-by":"crossref","unstructured":"Celi\u0144ska-L\u00f6wenhoff M, Musia\u0142 J. Late-onset systemic lupus erythematosus: clinical manifestations, course, and prognosis. Pol Arch Intern Med 2015; 125: 497\u2013499.","DOI":"10.20452\/pamw.2947"},{"key":"ref-1725680","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-024-05784-1"},{"key":"ref-1725681","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa477"},{"key":"ref-1725682","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2024.101938"},{"key":"ref-1725683","doi-asserted-by":"publisher","DOI":"10.1177\/0961203317696593"},{"key":"ref-1725684","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.2963"},{"key":"ref-1725685","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2019.09.009"},{"key":"ref-1725686","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-024-05579-4"},{"key":"ref-1725687","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:4"},{"key":"ref-1725688","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31822edf7f"},{"key":"ref-1725689","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.290723.los"},{"key":"ref-1725690","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.01.010"},{"key":"ref-1725691","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314563134"},{"key":"ref-1725692","unstructured":"Luppi F, Sebastiani M, Silva M, et al. Interstitial lung disease in Sj\u00f6gren\u2019s syndrome: a\u00a0clinical review. Clin Exp Rheumatol 2020; 38 Suppl 126: 291\u2013300."},{"key":"ref-1725693","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead297"},{"key":"ref-1725694","unstructured":"Maddison P, Farewell V, Isenberg D, et al.; Systemic Lupus International Collaborating Clinics. The\u00a0rate and pattern of organ damage in late onset systemic lupus erythematosus. J Rheumatol 2002; 29: 913\u2013917."},{"key":"ref-1725695","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-024-05623-3"},{"key":"ref-1725696","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad787"},{"key":"ref-1725697","doi-asserted-by":"crossref","unstructured":"Mahir L, Ezzahra Hsai F, Drissi Bourhanbour A, El Bakkouri J. Performance evaluation of\u00a0immunoblot for the\u00a0detection of anti-DNA antibodies compared to indirect immunofluorescence on Crithidia luciliae. J Hum Virol Retrovirol 2023; 10: 30\u201332.","DOI":"10.15406\/jhvrv.2023.10.00261"},{"key":"ref-1725698","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0284-3"},{"key":"ref-1725699","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215089"},{"key":"ref-1725700","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.45.4.354"},{"key":"ref-1725701","doi-asserted-by":"publisher","DOI":"10.1590\/1518-8345.1316.2800"},{"key":"ref-1725702","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/jgsyos"}],"container-title":["Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/reu.termedia.pl\/pdf-208170-137729","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reu.termedia.pl\/pdf-208170-137729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T07:01:42Z","timestamp":1774594902000},"score":1,"resource":{"primary":{"URL":"https:\/\/reu.termedia.pl\/Clinical-and-laboratory-differences-in-characteristics-of-patients-with-early-onset,208170,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":27,"alternative-id":["208170"],"URL":"https:\/\/doi.org\/10.5114\/reum\/208170","relation":{},"ISSN":["0034-6233","2084-9834"],"issn-type":[{"value":"0034-6233","type":"print"},{"value":"2084-9834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]}}}