{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T07:07:49Z","timestamp":1778483269125,"version":"3.51.4"},"reference-count":32,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to assess the prevalence of neuropathic pain in rheumatoid arthritis (RA) patients, and to identify associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>We conducted a\u00a0cross-sectional study in patients with RA. Neuropathic pain was evaluated using the DN4 (Douleur Neuropathique 4) and PainDETECT scores. Agreement between the 2 questionnaires was estimated through Cohen\u2019s k. Factors associated with neuropathic pain were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A\u00a0total of 121 patients with RA were included, with a\u00a0mean age of 57 \u00b112.2 years, and a\u00a0predominance of women (83%). The mean duration of RA was 16 \u00b11.0 years. The mean Disease Activity Score in 28 joints (DAS28) was 4.28 \u00b11.0, indicating moderate activity of the RA. According to the DN4 score, 61.2% of patients had neuropathic pain, and according to the PainDETECT score, 47.1% of patients were identified as having possible or likely neuropathic pain. Eighty-four patients (69.4%) had a\u00a0positive DN4 score and\/or a\u00a0positive PainDETECT score. The coefficient of agreement k between the 2 tests was 0.233, indicating a\u00a0fair agreement. Factors significantly associated with the presence of neuropathic pain were: female sex (p = 0.01), prolonged morning stiffness duration (p = 0.01), number of painful joints (p = 0.01), and number of swollen joints (p = 0.03). Additionally, the use of glucocorticosteroids (p = 0.001), analgesics (p = 0.03) and anti-CD20 drugs (p = 0.03) were significantly associated with neuropathic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study suggests a\u00a0potentially high prevalence of neuropathic pain in patients with RA, highlighting the need for early detection and appropriate management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/reum\/208944","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T06:08:09Z","timestamp":1778479689000},"page":"132-138","source":"Crossref","is-referenced-by-count":0,"title":["Neuropathic pain in rheumatoid arthritis: prevalence and associated factors"],"prefix":"10.5114","volume":"64","author":[{"given":"Selma","family":"Bouden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifa","family":"Khemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Rouached","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aicha","family":"Ben Tekaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siwar Ben","family":"Dhia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawdha","family":"Tekaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olfa","family":"Saidane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Abdelmoula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"ref-1855879","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120335"},{"key":"ref-1855880","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001939"},{"key":"ref-1855881","unstructured":"Junker U. Chronic pain: the \u201cmixed pain concept\u201d as a\u00a0new rational. Dtsch Arztebl Int 2004; 101: 1393."},{"key":"ref-1855882","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-020-00217-w"},{"key":"ref-1855883","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00393-7"},{"key":"ref-1855884","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.05.005"},{"key":"ref-1855885","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000860"},{"key":"ref-1855886","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001326"},{"key":"ref-1855887","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2021.01.001"},{"key":"ref-1855888","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2019.1650462"},{"key":"ref-1855889","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2020.1749677"},{"key":"ref-1855890","unstructured":"Freynhagen R, Baron R. The role of peripheral and central mechanisms in the development and persistence of neuropathic pain in rheumatoid arthritis. Rheumatology 2013; 52: 690\u2013698."},{"key":"ref-1855891","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"ref-1855892","doi-asserted-by":"publisher","DOI":"10.1016\/j.rhum"},{"key":"ref-1855893","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X132488"},{"key":"ref-1855894","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.12.010"},{"key":"ref-1855895","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12419"},{"key":"ref-1855896","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-022-00238-3"},{"key":"ref-1855897","unstructured":"Martins Rocha T, Pimenta S, Bernardo A, et al. Determinants of non-nociceptive pain in Rheumatoid Arthritis. Acta Reumatol Port 2018; 43: 291\u2013303."},{"key":"ref-1855898","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000001066"},{"key":"ref-1855899","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S69011"},{"key":"ref-1855900","doi-asserted-by":"publisher","DOI":"10.1177\/2049463713484296"},{"key":"ref-1855901","doi-asserted-by":"publisher","DOI":"10.17116\/jnevro20171178167-71"},{"key":"ref-1855902","doi-asserted-by":"crossref","unstructured":"Lee YC, Cui J, Lu B, et al. Pain persists in DAS28 rheumatoid arthritis remission but not in ACR\/EULAR remission: a\u00a0longitudinal observational study. 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