{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T08:09:26Z","timestamp":1763453366922,"version":"3.45.0"},"reference-count":48,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"abstract":"<jats:p>The risk of neoplasm is elevated in patients with various autoimmune diseases. Although the\u00a0overall risk of cancer in systemic lupus erythematosus (SLE) patients is slightly elevated, the\u00a0standardized incidence ratio of several cancers is above 3.0. The\u00a0main risk factor for neoplasm in this group is dysfunction of the\u00a0immune system caused by the\u00a0disease and by immunosuppressive drugs. The\u00a0most common cancers in patients with SLE are related to viral latent infections caused by human herpesvirus 8, Epstein-Barr virus, and human papillomavirus. The\u00a0risk of sarcoma has not been established in large cohort studies, but several case reports have been published. It remains uncertain whether there is a\u00a0direct relationship between sarcoma and SLE.\nWe performed a\u00a0systematic review of case reports and case series and analyzed the\u00a0detailed data of 26 SLE patients with sarcoma. The\u00a0most common sarcomas were Kaposi\u2019s sarcoma and leiomyosarcoma\u00a0\u2013\u00a02 neoplasms that are potentially related to viral infection.<\/jats:p>","DOI":"10.5114\/reum\/209383","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T08:04:46Z","timestamp":1763453086000},"source":"Crossref","is-referenced-by-count":0,"title":["Sarcoma in patients with systemic lupus erythematosus. A systematic review."],"prefix":"10.5114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7988-8708","authenticated-orcid":true,"given":"Wojciech","family":"Wo\u0142yniec","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz","family":"Szajewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz","family":"Na\u0142\u0119cz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"ref-1595544","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24425"},{"key":"ref-1595545","doi-asserted-by":"publisher","DOI":"10.1002\/art.21029"},{"key":"ref-1595546","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.4.437"},{"key":"ref-1595547","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2016-000156"},{"key":"ref-1595548","doi-asserted-by":"publisher","DOI":"10.3390\/genes-15091215"},{"key":"ref-1595549","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2016.03.001"},{"key":"ref-1595550","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(99)70372-0"},{"key":"ref-1595551","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03624.x"},{"key":"ref-1595552","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000202"},{"key":"ref-1595553","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)39886-5"},{"key":"ref-1595554","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.12.009"},{"key":"ref-1595555","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2017.1384054"},{"key":"ref-1595556","doi-asserted-by":"publisher","DOI":"10.1002\/art.21458"},{"key":"ref-1595557","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9151-8"},{"key":"ref-1595558","doi-asserted-by":"publisher","DOI":"10.1002\/art.30483"},{"key":"ref-1595559","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.50000"},{"key":"ref-1595560","doi-asserted-by":"crossref","unstructured":"Klein MB, Pereira FA, Kantor I. Kaposi Sarcoma complicating systemic lupus erythematosus treated with immunosuppression. Arch Dermatol 1974; 110: 602\u2013604.","DOI":"10.1001\/archderm.1974.01630100058014"},{"key":"ref-1595561","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(83)90351-5"},{"key":"ref-1595562","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.4.346"},{"key":"ref-1595563","unstructured":"el Maghraoui A, Sekkach Y, Qacif H, et al. Iatrogenic Kaposi\u2019s sarcoma following immunosuppressive therapy for systemic lupus erythematosus. Clin Exp Rheumatol 2003; 21: 674."},{"key":"ref-1595564","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.21.1.166"},{"key":"ref-1595565","doi-asserted-by":"publisher","DOI":"10.1080\/00313020701329864"},{"key":"ref-1595566","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2007.01967.x"},{"key":"ref-1595567","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1626-1-301"},{"key":"ref-1595568","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-3-39"},{"key":"ref-1595569","doi-asserted-by":"publisher","DOI":"10.1002\/art.33421"},{"key":"ref-1595570","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-11-244"},{"key":"ref-1595571","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-172"},{"key":"ref-1595572","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/830814"},{"key":"ref-1595573","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13154345"},{"key":"ref-1595574","unstructured":"Papazisis KT, Boura P, Foukas P, Dimitriadis KA. Corticosteroid-induced Kaposi\u2019s sarcoma in a\u00a0patient with systemic lupus erythematosus. Archive of Oncology 2000; 8: 181\u2013182."},{"key":"ref-1595575","doi-asserted-by":"publisher","DOI":"10.5603\/rdatf.103842"},{"key":"ref-1595576","unstructured":"Greenfield DI, Trinh P, Fulenwider A, Barth WF. Kaposi\u2019s sarcoma in a\u00a0patient with SLE. J Rheumatol 1986; 13: 637\u2013640."},{"key":"ref-1595577","unstructured":"Tamura G, Kaizuka H, Iwasaki T, et al. A\u00a0case report of angiosarcoma of the\u00a0breast. Gan No Rinsho 1987; 33: 1085\u20131089 [Article in Japanese]."},{"key":"ref-1595578","unstructured":"Fyfe AI, Huckell VF, Burr LH, Stonier PM. Leiomyosarcoma of the\u00a0left atrium: case report and review of the\u00a0literature. Can J Cardiol 1991; 7: 193\u2013196."},{"key":"ref-1595579","unstructured":"Fagone S, Cavaleri A, Camuto M, et al. Hyperkeratotic Kaposi sarcoma with leg lymphoedema after prolonged corticosteroid therapy for SLE. Case report and review of the\u00a0literature. Minerva Med 2001; 92: 177\u2013202 [Article in Italian]."},{"key":"ref-1595580","unstructured":"Ashfaq A, Haller JE, Mossey R, et al. Recurrent membranous nephropathy and leiomyosarcoma in the\u00a0renal allograft of a\u00a0lupus patient. J Nephrol 2004; 17: 134\u2013138."},{"key":"ref-1595581","unstructured":"Kim IK, Cho HY, Chang KS, et al. Kaposi\u2019s sarcoma of maxillary gingiva in systemic lupus erythematosus. Maxillofacial Plastic and Reconstructive Surgery 2009, 31: 343\u2013348 [Article in Korean]."},{"key":"ref-1595582","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.08.1995"},{"key":"ref-1595583","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0035"},{"key":"ref-1595584","unstructured":"Silva ME, D\u00e1bague J, Avila Casado MC, et al. Does heart sarcoma mimick lupus erythematosus and vasculitis? Report of 2 cases. 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Z Haut Geschlechtskr 1950; 8: 255\u2013258 [Article in Undetermined language]."},{"key":"ref-1595587","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19881201)62:11"},{"key":"ref-1595588","doi-asserted-by":"publisher","DOI":"10.4081\/dr.2024.9916"},{"key":"ref-1595589","doi-asserted-by":"publisher","DOI":"10.3390\/ph16040485"},{"key":"ref-1595590","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2013.13144"},{"key":"ref-1595591","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315598245"}],"container-title":["Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/reu.termedia.pl\/pdf-209383-132186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reu.termedia.pl\/pdf-209383-132186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T08:04:50Z","timestamp":1763453090000},"score":1,"resource":{"primary":{"URL":"https:\/\/reu.termedia.pl\/Sarcoma-in-patients-with-systemic-lupus-erythematosus-A-systematic-review-,209383,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":48,"alternative-id":["209383"],"URL":"https:\/\/doi.org\/10.5114\/reum\/209383","relation":{},"ISSN":["0034-6233","2084-9834"],"issn-type":[{"value":"0034-6233","type":"print"},{"value":"2084-9834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]}}}