{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T07:07:54Z","timestamp":1778483274470,"version":"3.51.4"},"reference-count":47,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Juvenile dermatomyositis (JDM) is the\u00a0most common inflammatory myopathy in childhood and exhibits a\u00a0heterogeneous disease course. This study aimed to analyse and identify phenotypic clusters by examining the\u00a0laboratory findings, nailfold capillaroscopy results, and myositis- specific autoantibodies (MSAs) in patients with JDM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included data from patients with JDM treated at the\u00a0Paediatric Rheumatology Departments of\u00a014 advanced health centres in Turkey. A\u00a0categorical principal component analysis (CATPCA)-based hierarchical cluster analysis method was employed for clustering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A\u00a0total of\u00a0176 JDM patients were enrolled, and 5 phenotypic clusters were identified using 23\u00a0categorical variables. These clusters were interpreted as follows: Cluster A\u00a0with severe muscle weakness and oesophageal involvement requiring intensive immunosuppressive treatment; Cluster B with amyopathic\/hypomyopathic patients; Cluster C with skin manifestations and lung involvement; Cluster D with complicated skin manifestations; and Cluster E with classic JDM. The\u00a0clinical and laboratory findings and treatments of\u00a0these 5 clusters were compared. Fatigue, myalgia, photosensiti\u00advity, Raynaud\u2019s phenomenon, and the\u00a0use of\u00a0pulse glucocorticosteroids, intravenous immuno\u00adglobulin, and cyclophosphamide treatments differed between the\u00a0groups (p &lt; 0.001, p = 0.002, p = 0.015, p = 0.036, p = 0.002, p = 0.006, and p = 0.024, respectively). Myositis-specific autoantibodies results were available for 119 patients (65.3%). The\u00a0most frequent MSAs were antinuclear matrix protein 2 (26.1%) and anti-transcription intermediary factor 1 (20.9%). However, no significant differences were found in MSAs or nailfold capillaroscopy findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identified 5 clusters based on patient symptoms and findings. The\u00a0identification of\u00a0these 5 clusters can guide more effective treatment strategies in clinical practice. Additionally, these approaches may contribute to improving patients\u2019 quality of\u00a0life and long-term outcomes by increasing the\u00a0feasibility of\u00a0individualised treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/reum\/209913","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T06:08:09Z","timestamp":1778479689000},"page":"83-93","source":"Crossref","is-referenced-by-count":0,"title":["A\u00a0multicentre study for clinical phenotype prediction in juvenile dermatomyositis: categorical principal component analysis-based hierarchical clustering"],"prefix":"10.5114","volume":"64","author":[{"given":"R\u00fcya","family":"Torun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00fc\u015ferref Kasap","family":"C\u00fcceo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Arslano\u011flu","family":"Ayd\u0131n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selen Duygu","family":"Ar\u0131k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayb\u00fcke","family":"G\u00fcnalp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadir","family":"Ulu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fclya","family":"K\u00f6se","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7isem","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zge","family":"Baba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceyhun","family":"A\u00e7ar\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00fcbra","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl\u015fah","family":"K\u0131lba\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice Ad\u0131g\u00fczel","family":"D\u00fcndar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sel\u00e7uk","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukaddes","family":"Kalyoncu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafize Emine","family":"S\u00f6nmez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevcan","family":"Bakkalo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara \u015eebnem","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bet\u00fcl","family":"S\u00f6zeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zg\u00fcr","family":"Kasap\u00e7opur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuray Aktay","family":"Ayaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Ba\u011flan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelda","family":"Bilginer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pembe","family":"Keskino\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erbil","family":"\u00dcnsal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"ref-1855709","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-"},{"key":"ref-1855710","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep302"},{"key":"ref-1855711","unstructured":"Pilkington CA, Feldman BM, Sontichai W. 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