{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T07:07:48Z","timestamp":1778483268470,"version":"3.51.4"},"reference-count":18,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The\u00a0relationship between lipid metabolism and inflammatory activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) remains unclear. This study evaluated whether serum low-density lipoprotein cholesterol (LDL-C) levels are associated with synovial vascularization measured by quantitative power Doppler ultrasonography (PDUS) in patients with active RA and PsA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>The\u00a0single-center study enrolled 60 patients diagnosed with RA and a\u00a0group of\u00a020 patients with PsA with the\u00a0clinical presentation resembling RA. Serum LDL-C levels were measured, and disease activity was assessed using the\u00a0Disease Activity Score in 28 joints with erythro\u00adcyte sedimentation rate and the\u00a0Simplified Disease Activity Index. Synovial membrane vascularization was quantified using PDUS, and a\u00a0vascularity index \u2013 the\u00a0PDUS index (INDEX%) \u2013 was calculated in the\u00a0region of\u00a0interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant correlation was found between serum LDL-C concentration and INDEX% for both groups (r = 0.2). The\u00a0majority of\u00a0patients in both groups (76.2%) had LDL-C levels in the\u00a0normal range, consistent with the\u00a0lipid paradox in inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum LDL-C levels were not correlated with INDEX%. These findings suggest that LDL-C levels do not significantly influence synovial membrane vascularization in patients with active RA or PsA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/reum\/213263","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T06:08:09Z","timestamp":1778479689000},"page":"77-82","source":"Crossref","is-referenced-by-count":0,"title":["Serum low-density lipoprotein and synovial vascularity in patients with active rheumatoid arthritis and psoriatic arthritis"],"prefix":"10.5114","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0783-7017","authenticated-orcid":true,"given":"Micha\u0142 Piotr","family":"Jakubaszek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-1830","authenticated-orcid":false,"given":"Brygida","family":"Kwiatkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3965-7146","authenticated-orcid":false,"given":"Mateusz","family":"P\u0142aza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2211-0302","authenticated-orcid":true,"given":"Maria","family":"Ma\u015bli\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"ref-1855691","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102735"},{"key":"ref-1855692","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2021.0929"},{"key":"ref-1855693","doi-asserted-by":"publisher","DOI":"10.1002\/art.42700"},{"key":"ref-1855694","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174500"},{"key":"ref-1855695","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054901"},{"key":"ref-1855696","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303566"},{"key":"ref-1855697","unstructured":"Linton MRF, Yancey PG, Davies SS, et al. The\u00a0Role of\u00a0Lipids and Lipoproteins in Atherosclerosis. [Updated 2019 Jan 3]. In: Fein\u00adgold KR, Ahmed SF, Anawalt B, et al. (eds.). Endotext [Internet]. MDText.com, Inc, South Dartmouth 2000. Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK343489\/ (Access: 10.07.2025)."},{"key":"ref-1855698","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03823-z"},{"key":"ref-1855699","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwae175.367"},{"key":"ref-1855700","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010533"},{"key":"ref-1855701","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P084277"},{"key":"ref-1855702","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.12.009"},{"key":"ref-1855703","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1254753"},{"key":"ref-1855704","doi-asserted-by":"publisher","DOI":"10.3390\/nu14061240"},{"key":"ref-1855705","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2018.74021"},{"key":"ref-1855706","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13761"},{"key":"ref-1855707","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3344-4"},{"key":"ref-1855708","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-12-20"}],"container-title":["Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/reu.termedia.pl\/pdf-213263-139737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reu.termedia.pl\/pdf-213263-139737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T06:08:12Z","timestamp":1778479692000},"score":1,"resource":{"primary":{"URL":"https:\/\/reu.termedia.pl\/Serum-low-density-lipoprotein-and-synovial-vascularity-in-patients-with-active-rheumatoid,213263,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"alternative-id":["213263"],"URL":"https:\/\/doi.org\/10.5114\/reum\/213263","relation":{},"ISSN":["0034-6233","2084-9834"],"issn-type":[{"value":"0034-6233","type":"print"},{"value":"2084-9834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]}}}