{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:54:09Z","timestamp":1789178049308,"version":"build-2803163510"},"reference-count":36,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"abstract":"\n Objectives<\/jats:title>\n Magnesium is essential in numerous physiological processes, including the inflammatory response. However, its role in the pathogenesis and progression of juvenile idiopathic arthritis (JIA) remains underexplored. This study aimed to assess dietary magnesium intake and serum magnesium levels in children with JIA and to evaluate their potential impact on the clinical course of the disease.<\/jats:p>\n <\/jats:sec>\n \n Material and methods<\/jats:title>\n This case-control study included 42 children with JIA and 67 healthy controls aged 2 to 18 years. Juvenile idiopathic arthritis was diagnosed according to International League of Associations for Rheumatology criteria. Dietary magnesium intake was assessed in 26 JIA patients using a food frequency questionnaire, which collected information on the weekly consumption of foods rich in magnesium. The average weekly and daily magnesium intake was calculated and compared with national and international dietary recommendations. Serum magnesium levels were measured using the colorimetric method.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Children with JIA had significantly lower dietary magnesium intake (median: 227.71 mg\/day vs. 261.18 mg\/day, <i>p<\/i> = 0.040) and serum magnesium concentrations (mean: 0.79 mmol\/l vs. 0.94 mmol\/l, <i>p<\/i> = 0.009) than healthy controls. Insufficient dietary intake was more prevalent in the JIA group (50.0%) compared to controls (26.9%) (<i>p<\/i> < 0.034). Juvenile idiopathic arthritis patients with insufficient dietary magnesium intake were more likely to be male (<i>p<\/i> = 0.006), older than 12 years (<i>p<\/i> = 0.049), and residing in urban areas (<i>p<\/i> = 0.002). Hypomagnesemia was more common in boys (<i>p<\/i> = 0.030). However, neither low magnesium intake nor hypomagnesemia significantly influenced JIA disease activity.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Children with JIA demonstrate significantly lower dietary and serum magnesium levels than their healthy peers. Larger pediatric studies are needed to clarify the potential contribution of magnesium to the development and clinical course of JIA.<\/jats:p>\n <\/jats:sec>","DOI":"10.5114\/reum\/214398","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:19:33Z","timestamp":1781158773000},"source":"Crossref","is-referenced-by-count":1,"title":["Dietary and serum magnesium in children with juvenile idiopathic arthritis: a case-control study"],"prefix":"10.5114","author":[{"given":"Oksana","family":"Boyarchuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliia","family":"Kovalchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vira","family":"Synytska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"ref-1899468","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S42054"},{"key":"ref-1899469","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2014"},{"key":"ref-1899470","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020320"},{"key":"ref-1899471","doi-asserted-by":"publisher","DOI":"10.1093\/ndtplus\/sfr163"},{"key":"ref-1899472","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2022-005623"},{"key":"ref-1899473","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2020.102010"},{"key":"ref-1899474","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-022-03810-4"},{"key":"ref-1899475","doi-asserted-by":"publisher","DOI":"10.15574\/SP.2023.135.7"},{"key":"ref-1899476","doi-asserted-by":"publisher","DOI":"10.3390\/nu14091714"},{"key":"ref-1899477","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214064"},{"key":"ref-1899478","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1992.263.3.R734"},{"key":"ref-1899479","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuy002"},{"key":"ref-1899480","doi-asserted-by":"publisher","DOI":"10.3390\/nu10121863"},{"key":"ref-1899481","doi-asserted-by":"publisher","DOI":"10.3390\/nu9020168"},{"key":"ref-1899482","unstructured":"Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. National Academies Press (US), Washington (DC) 1997."},{"key":"ref-1899483","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1477814"},{"key":"ref-1899484","unstructured":"Petty RE, Southwood TR, Manners P, et al; International League of Associations for Rheumatology. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 2004; 31: 390\u2013392."},{"key":"ref-1899485","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20497"},{"key":"ref-1899486","unstructured":"U.S. Department of Agriculture, Agricultural Research Service. Usual Nutrient Intake from Food and Beverages, by Gender and Age, What We Eat in America, NHANES 2013-2016; 2019."},{"key":"ref-1899487","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2021.107590"},{"key":"ref-1899488","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2020.98431"},{"key":"ref-1899489","unstructured":"Kremer JM, Bigaouette J. Nutrient intake of patients with rheumatoid arthritis is deficient in pyridoxine, zinc, copper, and magnesium. J Rheumatol 1996; 23: 990\u2013994."},{"key":"ref-1899490","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-039640"},{"key":"ref-1899491","doi-asserted-by":"publisher","DOI":"10.3390\/nu11020378"},{"key":"ref-1899492","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2018.77979"},{"key":"ref-1899493","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-16906-y"},{"key":"ref-1899494","doi-asserted-by":"publisher","DOI":"10.1186\/s41043-024-00597-1"},{"key":"ref-1899495","doi-asserted-by":"publisher","DOI":"10.2217\/whe.11.41"},{"key":"ref-1899496","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831\/a000255"},{"key":"ref-1899497","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.11.002"},{"key":"ref-1899498","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104603"},{"key":"ref-1899499","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00003.2017"},{"key":"ref-1899500","doi-asserted-by":"publisher","DOI":"10.3390\/nu16234247"},{"key":"ref-1899501","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2015\/12206.5740"},{"key":"ref-1899502","unstructured":"Afridi HI, Kazi TG, Kazi N, et al. Evaluation of calcium, magnesium, potassium, and sodium in biological samples (scalp hair, serum, blood, and urine) of Pakistani referents and arthritis patients of different age groups. Clin Lab 2012; 58: 7\u201318."},{"key":"ref-1899503","doi-asserted-by":"publisher","DOI":"10.1002\/art.1790060103"}],"container-title":["Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/reu.termedia.pl\/pdf-214398-141230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reu.termedia.pl\/pdf-214398-141230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:19:35Z","timestamp":1781158775000},"score":1,"resource":{"primary":{"URL":"https:\/\/reu.termedia.pl\/Dietary-and-serum-magnesium-in-children-with-juvenile-idiopathic-arthritis-a-case,214398,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":36,"alternative-id":["214398"],"URL":"https:\/\/doi.org\/10.5114\/reum\/214398","relation":{},"ISSN":["0034-6233","2084-9834"],"issn-type":[{"value":"0034-6233","type":"print"},{"value":"2084-9834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]}}}