{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:07:05Z","timestamp":1784012825494,"version":"3.55.0"},"reference-count":39,"publisher":"Termedia Sp. z.o.o.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The\u00a0use of\u00a0currently recommended treatments for fibromyalgia (FM), combining pharmacological and exercise-based therapies, is often challenging in clinical practice. Poor efficacy and adverse effects of\u00a0the\u00a0available drugs and low adherence to exercise-based therapies resulting from physical fatigue have often led to inadequate FM-related chronic pain relief. Hyperbaric oxygen the\u00adrapy (HBOT) has been reported to be a\u00a0potential emerging therapy for FM, offering pain relief with minimal physical burden and adverse effects. This review aims to evaluate the\u00a0efficacy and safety of\u00a0HBOT in managing FM, explicitly in female populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>A\u00a0systematic review and meta-analysis was performed in accordance with the\u00a0PRISMA flowchart in three databases, PubMed\/MEDLINE, Cochrane Library, and ScienceDirect, to identify studies published up to the\u00a0year 2025. The\u00a0Cochrane risk of\u00a0bias 2.0 tool was used to assess the\u00a0quality of\u00a0the\u00a0included studies. Statistical analyses were conducted using RevMan 5.4.1 software on studies that reported the\u00a0required numerical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This review included 5 eligible studies with a\u00a0total of\u00a0227 female participants with FM. The\u00a0results indicated that HBOT was associated with a\u00a0significantly greater reduction in pain compared to the\u00a0control [mean difference (MD) = \u20133.41, 95% CI: from \u20136.24 to \u20130.59]. Patients treated with HBOT showed reduced symptom severity compared to the\u00a0control (MD = 5.27, 95% CI: 2.11\u20138.44). Quality of\u00a0life was enhanced in HBOT, though it was not statistically significant. Furthermore, HBOT was well tolerated, with no serious adverse events reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HBOT appears to be a\u00a0promising adjunctive treatment for FM, demonstrating signi\u00adficant pain reduction, with no serious adverse events reported. However, the\u00a0current evidence is limited, and further high-quality studies are needed to confirm its effects on quality of\u00a0life and long-\nterm outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/reum\/217148","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:39:22Z","timestamp":1784011162000},"page":"181-191","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of\u00a0hyperbaric oxygen therapy for women with fibromyalgia: a\u00a0systematic review and meta-analysis of\u00a0randomized controlled trials"],"prefix":"10.5114","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7887-1162","authenticated-orcid":false,"given":"Maggie","family":"Liberty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2464-9907","authenticated-orcid":false,"given":"Andi Raga","family":"Ginting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2434-3118","authenticated-orcid":false,"given":"Dewi Masyithah","family":"Darlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0522-0523","authenticated-orcid":false,"given":"Peggy","family":"Liberty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0118-5841","authenticated-orcid":false,"given":"Satria","family":"Gohtama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"ref-1930284","doi-asserted-by":"publisher","DOI":"10.5114\/reum\/163094"},{"key":"ref-1930285","unstructured":"Bhargava J, Hurley JA. Fibromyalgia. In: StatPearls. StatPearls Publishing, Treasure Island (FL) 2025.\u00a0Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK540974\/."},{"key":"ref-1930286","doi-asserted-by":"publisher","DOI":"10.1016\/j.aehs.2024.09.004"},{"key":"ref-1930287","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11020223"},{"key":"ref-1930288","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocpiqo"},{"key":"ref-1930289","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2022"},{"key":"ref-1930290","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.18692"},{"key":"ref-1930291","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-"},{"key":"ref-1930292","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6541798"},{"key":"ref-1930293","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000001222"},{"key":"ref-1930294","doi-asserted-by":"publisher","DOI":"10.1177\/1759720x231182894"},{"key":"ref-1930295","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2023.12.016"},{"key":"ref-1930296","unstructured":"Pejic W, Frey N. Hyperbaric oxygen therapy for the\u00a0treatment of\u00a0chronic pain: a\u00a0review of\u00a0clinical effectiveness and cost-effectiveness. Canadian Agency for Drugs and Technologies in Health, Ottawa (ON) 2018. Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537956\/."},{"key":"ref-1930297","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"ref-1930298","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"ref-1930299","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-62161-5"},{"key":"ref-1930300","doi-asserted-by":"crossref","unstructured":"Izquierdo-Alventosa R, Ingl\u00e9s M, Cort\u00e9s-Amador S, et al. Comparative study of\u00a0the\u00a0effectiveness of\u00a0a\u00a0low-pressure hyper\u00adbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial. Ther Adv Musculoskelet Dis 2020; 12: 1759720X20930493, DOI: 10.1177\/ 1759720X20930493.","DOI":"10.1177\/1759720X20930493"},{"key":"ref-1930301","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2018.02495"},{"key":"ref-1930302","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127012"},{"key":"ref-1930303","doi-asserted-by":"publisher","DOI":"10.4103\/mgr.MEDGASRES-D-24-00013"},{"key":"ref-1930304","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232112926"},{"key":"ref-1930305","unstructured":"Barilaro G, Francesco Masala I, Parracchini R, et al. The\u00a0role of hyperbaric oxygen therapy in orthopedics and rheumatological diseases. Isr Med Assoc J 2017; 19: 429\u2013434.\u00a0."},{"key":"ref-1930306","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57090864"},{"key":"ref-1930307","doi-asserted-by":"crossref","unstructured":"Curtis K, Katz J, Djaiani C, et al. Evaluation of\u00a0a\u00a0hyperbaric oxy\u00adgen therapy intervention in individuals with fibromyalgia. Pain Med 2021; 22: 1324\u20131332, DOI:\u00a010.1093\/pm\/pnaa416.","DOI":"10.1093\/pm\/pnaa416"},{"key":"ref-1930308","doi-asserted-by":"publisher","DOI":"10.1177\/08850666890040-0204"},{"key":"ref-1930309","doi-asserted-by":"publisher","DOI":"10.4103\/mgr.MEDGASRES-D-24-"},{"key":"ref-1930310","doi-asserted-by":"publisher","DOI":"10.3390\/biom10091247"},{"key":"ref-1930311","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3172679"},{"key":"ref-1930312","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079995"},{"key":"ref-1930313","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-019-01569-w"},{"key":"ref-1930314","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2023.10.027"},{"key":"ref-1930315","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.157"},{"key":"ref-1930316","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1450134"},{"key":"ref-1930317","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget"},{"key":"ref-1930318","doi-asserted-by":"publisher","DOI":"10.1016\/j.jesf.2024.04.005"},{"key":"ref-1930319","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.924405"},{"key":"ref-1930320","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16173173"},{"key":"ref-1930321","doi-asserted-by":"crossref","unstructured":"Singhal AB, Maas MB, Goldstein JN, et al. High-flow oxygen therapy for treatment of\u00a0acute migraine: a\u00a0randomized crossover trial. Cephalalgia 2017 Jul; 37: 730\u2013736, DOI: 10.1177\/ 0333102416651453.","DOI":"10.1177\/0333102416651453"},{"key":"ref-1930322","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005219.pub3"}],"container-title":["Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/reu.termedia.pl\/pdf-217148-141998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reu.termedia.pl\/pdf-217148-141998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:39:29Z","timestamp":1784011169000},"score":1,"resource":{"primary":{"URL":"https:\/\/reu.termedia.pl\/Efficacy-and-safety-of-hyperbaric-oxygen-therapy-for-women-with-fibromyalgia-a-systematic,217148,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"alternative-id":["217148"],"URL":"https:\/\/doi.org\/10.5114\/reum\/217148","relation":{},"ISSN":["0034-6233","2084-9834"],"issn-type":[{"value":"0034-6233","type":"print"},{"value":"2084-9834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]}}}