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MiR-133a promotes osteoclastogenesis and inhibits osteogenesis, while miR-214-3p suppresses osteogenesis by targeting factors such as osterix. MiR-125b is upregulated in osteoporosis, negatively affecting osteogenic markers, and miR-21-5p shows complex, context-dependent effects on bone cells. Emerging candidates include miR-483-5p, miR-497-5p, and miR-422. These molecules provide insight into osteoporosis mechanisms and hold potential as diagnostic and therapeutic targets. Although miRNA-based therapies are promising, further studies are required to validate the findings and improve delivery strategies. Advances in miRNA research may enable earlier diagnosis and more effective osteoporosis treatment.<\/jats:p>","DOI":"10.5114\/reum\/220000","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:58:07Z","timestamp":1784271487000},"page":"338-344","source":"Crossref","is-referenced-by-count":0,"title":["MicroRNAs in osteoporosis: current evidence and clinical perspectives"],"prefix":"10.5114","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9002-8880","authenticated-orcid":false,"given":"Marta","family":"\u015awiecka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8126-8786","authenticated-orcid":true,"given":"Micha\u0142","family":"Chmielewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"ref-1935400","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2024.01.011"},{"key":"ref-1935401","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldaa005"},{"key":"ref-1935402","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116240"},{"key":"ref-1935403","doi-asserted-by":"publisher","DOI":"10.1007\/BF01622200"},{"key":"ref-1935404","doi-asserted-by":"publisher","DOI":"10.1007\/s43465-023-01059-2"},{"key":"ref-1935405","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-025-07422-3"},{"key":"ref-1935406","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137167"},{"key":"ref-1935407","doi-asserted-by":"publisher","DOI":"10.2174\/1389201023666220602102133"},{"key":"ref-1935408","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell"},{"key":"ref-1935409","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz097"},{"key":"ref-1935410","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21238887"},{"key":"ref-1935411","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034641"},{"key":"ref-1935412","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2014.935957"},{"key":"ref-1935413","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmy006"},{"key":"ref-1935414","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2021.0206"},{"key":"ref-1935415","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02278-w"},{"key":"ref-1935416","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107613"},{"key":"ref-1935417","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28818"},{"key":"ref-1935418","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1164252"},{"key":"ref-1935419","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.04.002"},{"key":"ref-1935420","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2015.1017205"},{"key":"ref-1935421","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2003.10.013"},{"key":"ref-1935422","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3026"},{"key":"ref-1935423","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934917"},{"key":"ref-1935424","doi-asserted-by":"publisher","DOI":"10.1159\/000443036"},{"key":"ref-1935425","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136745"},{"key":"ref-1935426","doi-asserted-by":"publisher","DOI":"10.1159\/000457013"},{"key":"ref-1935427","doi-asserted-by":"crossref","unstructured":"Chen H, Jiang H, Can D, et al. 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