{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:40:47Z","timestamp":1787067647962,"version":"build-2736575974"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"published-print":{"date-parts":[[2015,7,30]]},"abstract":"<jats:p>&lt;b&gt;Introduction: &lt;\/b&gt;Human leukocyte antigen B27 (HLA-B27) is considered as a risk factor for development of juvenile idiopathic arthritis (JIA).&lt;br \/&gt;\nThe aim of this study was to analyse the prevalence of HLA-B27 antigen in JIA categories and its influence on disease onset and response to conventional therapy.&lt;br \/&gt;\n&lt;b&gt;Material and methods&lt;\/b&gt;: The retrospective analysis included 461 unselected children with JIA hospitalized in a single reference rheumatology centre between July 2007 and June 2012. The diagnosis was based on criteria by the International League of Association for Rheumatology. HLA-B27 was determined in 387 of all patients (84%) by hybridization of the amplified, labelled product to immobilize it on the microarray probe.&lt;br \/&gt;\n&lt;b&gt;Results: &lt;\/b&gt; HLA-B27 antigen was found in 104 of 383 affected children (27.2%), 48 of 206 girls (23.3%), and 56 of 177 boys (31.6%) \u2013 most frequently in patients with enthesitis-related arthritis (71%), psoriatic arthritis (50%) and unclassified cases (86.7%). The age of JIA onset was slightly (by 1 year) but significantly different in patients with and without HLA-B27 antigen [11 (8.5\u201314) vs. 10 (5\u201313.5) years.; p &lt; 0.001].&lt;br \/&gt;\nThe use of disease-modifying antirheumatic drugs (DMARDs) and corticosteroids was more frequently clinically ineffective in HLA-B27 positive than negative patients (23.1% vs. 15.2%; p = 0.09). Patients with polyarthritis, systemic, and psoriatic arthritis more frequently received biological therapy. HLA-B27 positive patients with enthesitis-related arthritis received biological therapy more frequently than HLA-B27 negative ones (20.4% vs. 0, respectively; p = 0.09).&lt;br \/&gt;\n&lt;b&gt;Conclusions&lt;\/b&gt;: HLA-B27 antigen is a strong risk factor for the development of enthesitis-related arthritis, and to a lesser extent for psoriatic arthritis and extended course of oligoarthritis. The presence of this antigen does not affect the disease onset but seems to predict resistance to therapy with disease-modifying drugs and corticosteroids.<\/jats:p>","DOI":"10.5114\/reum.2015.53133","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T07:25:54Z","timestamp":1444202754000},"page":"125-130","source":"Crossref","is-referenced-by-count":26,"title":["Prevalence of HLA-B27 antigen in patients with juvenile idiopathic arthritis"],"prefix":"10.5114","volume":"53","author":[{"given":"Zbigniew","family":"\u017buber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Turowska-Heydel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Sobczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Chudek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2015,8,7]]},"container-title":["Rheumatology"],"original-title":["Cz\u0119sto\u015b\u0107 wyst\u0119powania antygenu HLA B27 u pacjent\u00f3w choruj\u0105cych na m\u0142odzie\u0144cze idiopatyczne zapalenie staw\u00f3w"],"link":[{"URL":"https:\/\/reu.termedia.pl\/pdf-57284-86455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reu.termedia.pl\/pdf-57284-86455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T15:59:19Z","timestamp":1675094359000},"score":1,"resource":{"primary":{"URL":"https:\/\/reu.termedia.pl\/Prevalence-of-HLA-B27-antigen-in-patients-with-juvenile-idiopathic-arthritis,57284,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,30]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015]]}},"alternative-id":["57284"],"URL":"https:\/\/doi.org\/10.5114\/reum.2015.53133","relation":{},"ISSN":["0034-6233","2084-9834"],"issn-type":[{"value":"0034-6233","type":"print"},{"value":"2084-9834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,30]]}}}