{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:50:34Z","timestamp":1783075834270,"version":"3.54.6"},"reference-count":18,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"published-print":{"date-parts":[[2017,4,28]]},"abstract":"<b>Objectives<\/b>: The pathergy skin test is a hypersensitivity reaction to a prick skin trauma caused by a pin or a needle, which is considered as a specific presentation in Beh\u00e7et\u2019s disease (BD) and the precise mechanism of this test is not well elucidated. This study was designed to evaluate the association of pathergy reaction (PR) with the active clinical manifestations of BD patients, to assess the clinical importance of PR.<br \/>\n<b>Materials and methods<\/b>: This was a cohort study on 1675 BD patients who fulfilled the entry criteria based on the International Criteria for Beh\u00e7et\u2019s Disease (ICBD) from 1975 to 2011. The patients were divided into two groups; the pathergy positive group included 841 patients (50.2%) and the pathergy negative group 834 patients (49.8%). The active mucocutaneous and systemic disease manifestations were analyzed according to the presence of the PR. The odds ratio and 95% confidence interval (95% CI) were calculated for each item.<br \/>\n<b>Results<\/b>: In this study, 841 patients (50.2%) had a positive pathergy test. Patient\u2019s mean age and mean disease duration were similar in the two groups (pathergy positive and pathergy negative patients). There was no association between positive pathergy test and age of patients, or disease duration. The PR was associated with male gender (p = 0.013), oral aphthosis (p < 0.001), pseudofolliculitis (p < 0.001), anterior uveitis (p = 0.001) and posterior uveitis (p = 0.028).<br \/>\n<b>Conclusions<\/b>: The presence of PR was associated with male gender, as well as some of mucocutaneous manifestations and uveitis in adult patients. There was no association with retinitis and vascular involvements. PR isn\u2019t associated with the severity of the disease.<\/jats:p>","DOI":"10.5114\/reum.2017.67602","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T11:18:55Z","timestamp":1496229535000},"page":"79-83","source":"Crossref","is-referenced-by-count":18,"title":["The association of pathergy reaction and active clinical presentations of Beh\u00e7et\u2019s disease"],"prefix":"10.5114","volume":"55","author":[{"given":"Shirin","family":"Assar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereydoun","family":"Davatchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyedeh Zahra","family":"Ghodsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolhadi","family":"Nadji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Shahram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farimah","family":"Ashofte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyedeh Roghieh","family":"Larimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2017,4,28]]},"reference":[{"key":"ref-795139","doi-asserted-by":"crossref","unstructured":"Davatchi F. Davatchi F. Beh\u00e7et\u2019s disease. In: Ashit S.Text book of rheumatology: Principals and Practice. Japee Brotheus; 2010: 249-268.","DOI":"10.5005\/jp\/books\/11169_17"},{"key":"ref-795140","unstructured":"Shahram F, Davatchi F, Akbarian M. The1996 survey of Behcet\u2019s disease in Iran, study of 3153 cases. In: Beh\u00e7et\u2019s Disease. Hamza M (ed.). Pub Adhoua, Tunisia 1997; 165-169."},{"key":"ref-795141","doi-asserted-by":"crossref","unstructured":"Gul A, Esin S, Dilsen N, et al. Immunohistology of skin pathergy reaction in Behcet\u2019s disease. Dermatol 1995; 132: 901-907.","DOI":"10.1111\/j.1365-2133.1995.tb16946.x"},{"key":"ref-795142","unstructured":"Chams-Davatchi C, Davatchi F, Shahram F, et al. Longitudinal study of the Pathergy phenomenon in Behcet\u2019s disease. In: Beh\u00e7et\u2019s Disease. Hamza M (ed.). Pub Adhoua, Tunisia 1997; 356-358."},{"key":"ref-795143","doi-asserted-by":"crossref","unstructured":"Davatchi F, Shahram F, Chams C, et al. Beh\u00e7et\u2019s disease. Acta Medica Iranica 2005; 43: 233-242.","DOI":"10.1111\/j.1479-8077.2005.00121.x"},{"key":"ref-795144","doi-asserted-by":"crossref","unstructured":"Davatchi F, Shahram F, Chams-Davatchi C, et al. Behcet\u2019s disease: from east to west. Clin Rheumatol 2010; 29: 823-833.","DOI":"10.1007\/s10067-010-1430-6"},{"key":"ref-795145","doi-asserted-by":"crossref","unstructured":"Davatchi F, Chams C, Ghodsi Z. Diagnostic value of Pathergy Test in Behcet\u2019s Disease according to the change of incidence over the time. Clin Rheumatol 2011; 30: 1151-1155.","DOI":"10.1007\/s10067-011-1694-5"},{"key":"ref-795146","unstructured":"International Team for the Revision of the International Criteria for Behcet\u2019s Disease. Revision of the international criteria for Behcet\u2019s disease (ICBD). Clin Exp Rheumatol 2006; 24: S14-15."},{"key":"ref-795147","doi-asserted-by":"crossref","unstructured":"Chang HK, Cheon KS. 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Royal Society of Medicine Services, London 1986: 177-180."}],"container-title":["Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/reu.termedia.pl\/pdf-70341-86306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reu.termedia.pl\/pdf-70341-86306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T20:54:03Z","timestamp":1675112043000},"score":1,"resource":{"primary":{"URL":"https:\/\/reu.termedia.pl\/The-association-of-pathergy-reaction-and-active-clinical-presentations-of-Behcet,70341,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,28]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017]]}},"alternative-id":["70341"],"URL":"https:\/\/doi.org\/10.5114\/reum.2017.67602","relation":{},"ISSN":["0034-6233","2084-9834"],"issn-type":[{"value":"0034-6233","type":"print"},{"value":"2084-9834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,28]]}}}