{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:14:32Z","timestamp":1784402072009,"version":"3.55.0"},"reference-count":30,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"published-print":{"date-parts":[[2019,4,29]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Eosinophilic fasciitis (EF) was described in 1974 by Shulman as a rare fibrosing connective tissue disease of unknown etiology. An undetermined trigger is thought to lead to the degranulation of eosinophils that interact with fibroblasts and express fibrogenic cytokines including the transforming factor of tumor growth a and b and interleukins 1 and 6. The purpose of this study was to summarize seven cases of EF in a central hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This was a retrospective and descriptive study of a population with EF of a central hospital. All patients diagnosed with EF in a hospital unit were admitted to the study between January 1, 2005, and April 30, 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of seven patients diagnosed with EF were analyzed. The median age of the population at the time of diagnosis was 56 years, and 57% of the patients were women. All patients had elevated peripheral eosinophilia and sedimentation rate, and only one patient had hypergammaglobulinemia. All patients had edema and cutaneous thickening of the limbs, 57% had constitutional symptoms, and 57% had inflammatory arthritis with joint contracture. Prednisolone (PDN) therapy was initiated in all patients, and only in two was the association of PDN with methotrexate (MTX) initially performed. In one patient triple therapy of PDN, MTX, and cyclosporine was required. At the time of this publication, only one patient maintains active disease, and tocilizumab has been initiated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recent studies show a more favorable response from the combination of PDN and MTX than from PDN alone. Considering the rarity of the disease, more long-term studies are needed regarding the etiopathogenetics, progression, recurrence of EF, and new effective therapies.<\/jats:p><\/jats:sec>","DOI":"10.5114\/reum.2019.84813","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T11:36:16Z","timestamp":1557920176000},"page":"85-90","source":"Crossref","is-referenced-by-count":22,"title":["Eosinophilic fasciitis (Shulman\u2019s disease): review and comparative evaluation of seven patients"],"prefix":"10.5114","volume":"57","author":[{"given":"Joana","family":"Urzal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Cimbron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"Farinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"key":"ref-775938","first-page":"46","article-title":"Diffuse fasciitis with hypergammaglobulinemia and eosinophilia: a new syndrome? (abstract)","volume":"1","author":"Shulman LE","year":"1974","unstructured":"Shulman LE. (1974). Diffuse fasciitis with hypergammaglobulinemia and eosinophilia: a new syndrome? (abstract) J Rheumatol. 1: 46.","journal-title":"J Rheumatol"},{"key":"ref-775939","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0025-7125(16)30625-3","article-title":"Eosinophilic fasciitis","volume":"73","author":"Doyle JA","year":"1989","unstructured":"Doyle JA, Ginsburg WW. (1989). Eosinophilic fasciitis Med Clin North Am. 73: 1157-1166.","journal-title":"Med Clin North Am"},{"key":"ref-775940","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3109\/03009747909114628","article-title":"Eosinophilic fasciitis. Review and report of six cases","volume":"8","author":"Nassonova VA","year":"1979","unstructured":"Nassonova VA, Ivanova MM, Akhnazarova VD, et al. (1979). Eosinophilic fasciitis. Review and report of six cases Scand J Rheumatol. 8: 225-233.","journal-title":"Scand J Rheumatol"},{"key":"ref-775941","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1136\/jnnp.49.3.324","article-title":"Eosinophilic fasciitis and the carpal tunnel syndrome","volume":"49","author":"Jones HR","year":"1986","unstructured":"Jones HR, Beetham WP, Silverman ML, Margles SW. (1986). Eosinophilic fasciitis and the carpal tunnel syndrome J Neurol Neurosurg Psychiatry. 49: 324-327.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref-775942","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s00431-002-1038-1","article-title":"Eosinophilic fasciitis leading to painless contractures","volume":"161","author":"Huppke P","year":"2002","unstructured":"Huppke P, Wilken B, Brockmann K, et al. (2002). Eosinophilic fasciitis leading to painless contractures Eur J Pediatr. 161: 528-530.","journal-title":"Eur J Pediatr"},{"key":"ref-775943","first-page":"259","article-title":"Eosinophilic fasciitis is clinically distinguishable from the eosinophilia-myalgia syndrome and is not associated with L-tryptophan use","volume":"18","author":"Varga J","year":"1991","unstructured":"Varga J, Griffin R, Newman JH, Jimenez SA. (1991). Eosinophilic fasciitis is clinically distinguishable from the eosinophilia-myalgia syndrome and is not associated with L-tryptophan use J Rheumatol. 18: 259-263.","journal-title":"J Rheumatol"},{"key":"ref-775944","first-page":"311","article-title":"Eosinophilic pleuropericarditis and fasciitis. A new case","volume":"57","author":"Rizzo S","year":"2002","unstructured":"Rizzo S. (2002). Eosinophilic pleuropericarditis and fasciitis. A new case Monaldi Arch Chest Dis. 57: 311-313.","journal-title":"Monaldi Arch Chest Dis"},{"key":"ref-775945","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/pmj.76.891.36","article-title":"Eosinophilic fasciitis with pulmonary and pleural involvement","volume":"76","author":"Killen JW","year":"2000","unstructured":"Killen JW, Swift GL, White RJ. (2000). Eosinophilic fasciitis with pulmonary and pleural involvement Postgrad Med J. 76: 36-37.","journal-title":"Postgrad Med J"},{"key":"ref-775946","first-page":"259","article-title":"Eosinophilic fasciitis is clinically distinguishable from the eosinophilia-myalgia syndrome and is not associated with L-tryptophan use","volume":"18","author":"Varga J","year":"1991","unstructured":"Varga J, Griffin R, Newman JH, Jimenez SA. (1991). Eosinophilic fasciitis is clinically distinguishable from the eosinophilia-myalgia syndrome and is not associated with L-tryptophan use J Rheumatol. 18: 259-263.","journal-title":"J Rheumatol"},{"key":"ref-775947","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jaci.2005.06.031","article-title":"Eosinophil-fibroblast interactions induce fibroblast IL-6 secretion and extracellular matrix gene expression: implications in fibrogenesis","volume":"116","author":"Gomes I","year":"2005","unstructured":"Gomes I, Mathur SK, Espenshade BM, et al. (2005). Eosinophil-fibroblast interactions induce fibroblast IL-6 secretion and extracellular matrix gene expression: implications in fibrogenesis J Allergy Clin Immunol. 116: 796-804.","journal-title":"J Allergy Clin Immunol"},{"key":"ref-775948","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000063916","article-title":"Eosinophilic fasciitis (Shulman syndrome)","volume":"205","author":"Mosconi S","year":"2002","unstructured":"Mosconi S, Streit M, Br\u00f6nimann M, Braathen L. (2002). Eosinophilic fasciitis (Shulman syndrome) Dermatology. 205: 204-206.","journal-title":"Dermatology"},{"key":"ref-775949","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/120347540100500108","article-title":"Eosinophilic fasciitis occurring four weeks after the onset of dialysis in a renal failure patient","volume":"5","author":"Florell SR","year":"2001","unstructured":"Florell SR, Egan CA, Gregory MC, et al. (2001). Eosinophilic fasciitis occurring four weeks after the onset of dialysis in a renal failure patient J Cutan Med Surg. 5: 33-36.","journal-title":"J Cutan Med Surg"},{"key":"ref-775950","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1159\/000018271","article-title":"Eosinophilic fasciitis following idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia and Hashimoto\u2019s disease","volume":"199","author":"Bachmeyer C","year":"1999","unstructured":"Bachmeyer C, Monge M, Dh\u00f4te R, et al. (1999). Eosinophilic fasciitis following idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia and Hashimoto\u2019s disease Dermatology. 199: 282.","journal-title":"Dermatology"},{"key":"ref-775951","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12016-015-8485-8","article-title":"Eosinophilic Skin Diseases: A Comprehensive Review","volume":"50","author":"Long H","year":"2016","unstructured":"Long H, Zhang G, Wang L, Lu Q. (2016). Eosinophilic Skin Diseases: A Comprehensive Review Clin Rev Allergy Immunol. 50: 189-213.","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref-775952","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.autrev.2014.01.019","article-title":"Diagnosis and classification of eosinophilic fasciitis","volume":"13","author":"Pinal-Fernandez I","year":"2014","unstructured":"Pinal-Fernandez I, Selva-O\u2019Callaghan A, Grau JM. (2014). Diagnosis and classification of eosinophilic fasciitis Autoimmun Rev. 13: 379-382.","journal-title":"Autoimmun Rev"},{"key":"ref-775953","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/RLU.0000000000000260","article-title":"Usefulness of FDG PET\/CT in the diagnosis of eosinophilic fasciitis","volume":"39","author":"Kim HJ","year":"2014","unstructured":"Kim HJ, Lee SW, Kim GJ, Lee JH. (2014). Usefulness of FDG PET\/CT in the diagnosis of eosinophilic fasciitis Clin Nucl Med. 39: 801-802.","journal-title":"Clin Nucl Med"},{"key":"ref-775954","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/RHU.0000000000000020","article-title":"Ultrasound assessment of subcutaneous compressibility: a potential adjunctive diagnostic tool in eosinophilic fasciitis","volume":"19","author":"Kissin EY","year":"2013","unstructured":"Kissin EY, Garg A, Grayson PC, et al. (2013). Ultrasound assessment of subcutaneous compressibility: a potential adjunctive diagnostic tool in eosinophilic fasciitis J Clin Rheumatol. 19: 382-385.","journal-title":"J Clin Rheumatol"},{"key":"ref-775955","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4168\/aair.2014.6.2.179","article-title":"A case of eosinophilic fasciitis presenting as pitting edema of the lower extremities","volume":"6","author":"Lee HS","year":"2014","unstructured":"Lee HS, Chang SJ, Kang MS, et al. (2014). A case of eosinophilic fasciitis presenting as pitting edema of the lower extremities Allergy Asthma Immunol Res. 6: 179-182.","journal-title":"Allergy Asthma Immunol Res"},{"key":"ref-775956","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s10067-006-0525-6","article-title":"Eosinophilic fasciitis: report of two cases and a systematic review of the literature dealing with clinical variables that predict outcome","volume":"26","author":"Endo Y","year":"2007","unstructured":"Endo Y, Tamura A, Matsushima Y, et al. (2007). Eosinophilic fasciitis: report of two cases and a systematic review of the literature dealing with clinical variables that predict outcome Clin Rheumatol. 26: 1445-1451.","journal-title":"Clin Rheumatol"},{"key":"ref-775957","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1136\/annrheumdis-2012-202657","article-title":"Outcomes of patients with systemic sclerosis-associated polyarthritis and myopathy treated with tocilizumab or abatacept: a EUSTAR observational study","volume":"72","author":"Elhai M","year":"2013","unstructured":"Elhai M, Meunier M, Matucci-Cerinic M, et al. (2013). Outcomes of patients with systemic sclerosis-associated polyarthritis and myopathy treated with tocilizumab or abatacept: a EUSTAR observational study Ann Rheum Dis. 72: 1217-1220.","journal-title":"Ann Rheum Dis"},{"key":"ref-775958","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.hemonc.2013.12.003","article-title":"Eosinophilic fasciitis as a paraneoplastic syndrome, a case report and review of the literature","volume":"7","author":"Haddad H","year":"2014","unstructured":"Haddad H, Sundaram S, Magro C, Gergis U. (2014). Eosinophilic fasciitis as a paraneoplastic syndrome, a case report and review of the literature Hematol Oncol Stem Cell Ther. 7: 90-92.","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"ref-775959","first-page":"1364","article-title":"Compartment syndrome as a late complication of eosinophilic fasciitis","volume":"16","author":"Niskanen L","year":"1989","unstructured":"Niskanen L, Tulla H, Fr\u00e4ki J, Tahvanainen K. (1989). Compartment syndrome as a late complication of eosinophilic fasciitis J Rheumatol. 16: 1364-1365.","journal-title":"J Rheumatol"},{"key":"ref-775960","doi-asserted-by":"crossref","first-page":"224","DOI":"10.4103\/ijdvl.IJDVL_306_16","article-title":"Eosinophilic fasciitis associated with Raynaud\u2019s phenomenon, esophageal dysmotility, positive antinuclear antibody and anti-neutrophil cytoplasmic antibody","volume":"84","author":"Behera B","year":"2018","unstructured":"Behera B, Singh N, Chandrashekar L, et al. (2018). Eosinophilic fasciitis associated with Raynaud\u2019s phenomenon, esophageal dysmotility, positive antinuclear antibody and anti-neutrophil cytoplasmic antibody Indian J Dermatol Venereol Leprol. 84: 224-227.","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref-775961","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/BF02206669","article-title":"Eosinophilic fasciitis presenting with a reactive hepatitis","volume":"10","author":"Loeliger AE","year":"1991","unstructured":"Loeliger AE, van den Brink HR, Derksen RH, Bijlsma JW. (1991). Eosinophilic fasciitis presenting with a reactive hepatitis Clin Rheumatol. 10: 440-444.","journal-title":"Clin Rheumatol"},{"key":"ref-775962","first-page":"bcr20126158","article-title":"Eosinophilic fasciitis","volume":"2012","author":"Tsoi KL","year":"2012","unstructured":"Tsoi KL, Custers M, Bij de Vaate L, Jacobs JWG. (2012). Eosinophilic fasciitis BMJ Case Rep. 2012: bcr20126158.","journal-title":"BMJ Case Rep"},{"key":"ref-775963","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-4632.2007.03544.x","article-title":"Eosinophilic fasciitis: demographics, disease pattern and response to treatment: report of 12 cases and review of the literature","volume":"47","author":"Bischoff L","year":"2008","unstructured":"Bischoff L, Derk CT. (2008). Eosinophilic fasciitis: demographics, disease pattern and response to treatment: report of 12 cases and review of the literature Int J Dermatol. 47: 29-35.","journal-title":"Int J Dermatol"},{"key":"ref-775964","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000093847","article-title":"Eosinophilic fasciitis 30 years after \u2013 what do we really know? Report of 11 patients and review of the literature","volume":"213","author":"Antic M","year":"2006","unstructured":"Antic M, Lautenschlager S, Itin PH. (2006). Eosinophilic fasciitis 30 years after \u2013 what do we really know? Report of 11 patients and review of the literature Dermatology. 213: 93-101.","journal-title":"Dermatology"},{"key":"ref-775965","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/rheumatology\/ker366","article-title":"Eosinophilic fasciitis (Shulman disease): new insights into the therapeutic management from a series of 34 patients","volume":"51","author":"Lebeaux D","year":"2012","unstructured":"Lebeaux D, Franc\u00e8s C, Barete S, et al. (2012). Eosinophilic fasciitis (Shulman disease): new insights into the therapeutic management from a series of 34 patients Rheumatology (Oxford). 51: 557-561.","journal-title":"Rheumatology (Oxford)"},{"key":"ref-775966","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0049-0172(88)90008-X","article-title":"Eosinophilic fasciitis: clinical spectrum and therapeutic response in 52 cases","volume":"17","author":"Lakhanpal S","year":"1988","unstructured":"Lakhanpal S, Ginsburg WW, Michet CJ, et al. (1988). Eosinophilic fasciitis: clinical spectrum and therapeutic response in 52 cases Semin Arthritis Rheum. 17: 221-231.","journal-title":"Semin Arthritis Rheum"},{"key":"ref-775967","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jbspin.2015.02.008","article-title":"Efficacy of Tocilizumab in the treatment of Eosinophilic fasciitis: Report of one case","volume":"82","author":"Espinoza F","year":"2015","unstructured":"Espinoza F, Jorgensen C, Pers Y-M. (2015). Efficacy of Tocilizumab in the treatment of Eosinophilic fasciitis: Report of one case Joint Bone Spine. 82: 460-461.","journal-title":"Joint Bone Spine"}],"container-title":["Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/reu.termedia.pl\/pdf-106257-85797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reu.termedia.pl\/pdf-106257-85797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T08:34:51Z","timestamp":1674808491000},"score":1,"resource":{"primary":{"URL":"https:\/\/reu.termedia.pl\/Eosinophilic-fasciitis-Shulman-s-disease-review-and-comparative-evaluation-of-seven,106257,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,29]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019]]}},"alternative-id":["106257"],"URL":"https:\/\/doi.org\/10.5114\/reum.2019.84813","relation":{},"ISSN":["0034-6233","2084-9834"],"issn-type":[{"value":"0034-6233","type":"print"},{"value":"2084-9834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,29]]}}}