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Many ankylosing spondylitis patients suffer from concomitant osteopenia or osteoporosis, which represent indications for calcium supplementation. Conversely, there are still concerns about the use of calcium salts for the prevention of bone fragility in non-osteoporotic or non-osteopenic patients. &lt;br \/&gt;\nIn these cases, biologic agents may indirectly normalize calcium dysmetabolism by rebalancing the cyto\u00adkine milieu, in turn associated with bone remodeling. Calcium supplements may be disadvantageous for entheseal calcifications, but so far there are no clear data confirming that such an association exists.<\/jats:p>","DOI":"10.5114\/reum.2020.100112","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T12:35:55Z","timestamp":1605530155000},"page":"297-311","source":"Crossref","is-referenced-by-count":6,"title":["Calcium physiology, metabolism and supplementation: a\u00a0glance at patients with ankylosing spondylitis"],"prefix":"10.5114","volume":"58","author":[{"given":"Rossella","family":"Talotta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Rucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Scaglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"ref-780130","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2015.08.006"},{"key":"ref-780131","doi-asserted-by":"publisher","DOI":"10.1159\/000380990"},{"key":"ref-780132","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0298-6_4"},{"key":"ref-780133","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2018.01.014"},{"key":"ref-780134","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210770"},{"key":"ref-780135","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24025"},{"key":"ref-780136","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2015-000053"},{"key":"ref-780137","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2015.07.008"},{"key":"ref-780138","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1007\/s10067-017-3749-8","article-title":"Enthesis as a target organ in rheumatic diseases: an expanding frontier","volume":"36","author":"Slobodin G","year":"2017","unstructured":"Slobodin G, Rosner I. 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