{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:57:03Z","timestamp":1792421823766,"version":"4.5.0"},"reference-count":60,"publisher":"Termedia Sp. z.o.o.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"published-print":{"date-parts":[[2020,10,29]]},"abstract":"<jats:p>Hyperuricemia, i.e. increased serum uric acid (UA) concentration, is a\u00a0common problem in clinical practice. While there are clear guidelines concerning management of symptomatic hyperuricemia in acute conditions such as gout, urolithiasis or acute urate nephropathy, less is known about their secondary prevention. Moreover, despite the ongoing debate on the role of UA in the pathogenesis of chronic kidney disease, hypertension, cardiovascular disease and heart failure, the management of asymptomatic hyperuricemia in patients with these chronic conditions is still mainly up to physicians\u2019 judgement. Individual considerations should always be taken into account when prescribing urate-lowering therapy. &lt;br \/&gt;\nIn this narrative review study, we attempt to present current trends concerning treatment of patients with either symptomatic or asymptomatic hyperuricemia in the light of the available knowledge on the role of hyperuricemia in the development of gout, renal, cardiovascular and other diseases.<\/jats:p>","DOI":"10.5114\/reum.2020.100140","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T12:35:55Z","timestamp":1605530155000},"page":"312-323","source":"Crossref","is-referenced-by-count":96,"title":["Pathophysiology of hyperuricemia and its clinical significance \u2013 a\u00a0narrative review"],"prefix":"10.5114","volume":"58","author":[{"given":"Marta","family":"Skoczy\u0144ska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Chowaniec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Szymczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Langner-Hetma\u0144czuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Maci\u0105\u017cek-Chyra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Wiland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"ref-780259","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00160"},{"key":"ref-780260","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-014-0175-z"},{"key":"ref-780261","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.69.8.594"},{"key":"ref-780262","doi-asserted-by":"publisher","DOI":"10.12659\/msm.899852"},{"key":"ref-780263","doi-asserted-by":"publisher","DOI":"10.1186\/ar2519"},{"key":"ref-780264","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S87202"},{"key":"ref-780265","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2005.11.014"},{"key":"ref-780266","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2727.187916"},{"key":"ref-780267","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/301021"},{"key":"ref-780268","first-page":"1295","article-title":"Is it time to revise the normal range of serum uric acid levels?","volume":"18","author":"Desideri G","year":"2014","unstructured":"Desideri G, Castaldo G, Lombardi A, et al. 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