{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:19:36Z","timestamp":1790803176289,"version":"4.1.0"},"reference-count":16,"publisher":"Termedia Sp. z.o.o.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"published-print":{"date-parts":[[2020,9,29]]},"abstract":"Objectives<\/jats:title>The study aim was to prospectively evaluate the relationship between disease flare development in children with juvenile idiopathic arthritis (JIA) after discontinuation of treatment and serum calprotectin levels (MRP8\/14).<\/jats:p><\/jats:sec>Material and methods<\/jats:title>Determination of blood serum level of calprotectin was performed in \n54 patients with inactive JIA from various regions of Ukraine. The inclusion criterion was the existence of an inactive state of the disease in children with JIA for at least 6 months. During 1 week after blood sampling for determination of serum calprotectin (MRP8\/14) level the patients were completely discontinued of all therapy. Determination of calprotectin level in blood serum was performed with reagents EK-MRP8\/14 Buhlmann (MRP8\/14; S100A8\/9), Switzerland, using the ELISA method.<\/jats:p><\/jats:sec>Results<\/jats:title>The trial results showed that 3 months after discontinuation of treatment in patients with inactive JIA, the flares developed in 5 out of 54 patients (9.3%). The median calprotectin level before discontinuation of the treatment was 1,700 ng\/ml in patients who developed a flare, and 1,500 ng\/ml in other studied patients (not statistically significant). At 6 months, the flare had developed in an additional 3 out of 48 (6.3%) of patients, who continued to be followed up, while their median calprotectin serum levels were 1,300 ng\/ml and 1,500 ng\/ml respectively (not statistically significant). At 12 months, the flares had developed in 13 more out of 45 (28.9%) patients, who continued to be followed up, while the median calprotectin serum level in these patients before discontinuation of treatment was 1,100 ng\/ml and 1,650 ng\/ml respectively (not statistically significant).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>After discontinuation of treatment a flare over the next year of follow-up developed in 38.9% of patients. The study results did not reveal a significant difference in calprotectin level in patients with JIA prior to complete discontinuation of treatment who developed a flare and those without a flare after 3, 6 and 12 months.<\/jats:p><\/jats:sec>","DOI":"10.5114\/reum.2020.98431","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T08:36:07Z","timestamp":1600245367000},"page":"202-207","source":"Crossref","is-referenced-by-count":12,"title":["Blood calprotectin in children with juvenile idiopathic arthritis: relationship to flare development after discontinuation of treatment"],"prefix":"10.5114","volume":"58","author":[{"given":"Yaryna","family":"Boyko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoriia","family":"Ivanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryna","family":"Vakaruk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamila","family":"Kozina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliia","family":"Shevchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliia","family":"Vaizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olha","family":"Synoverska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Chubata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olha","family":"Marchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Havrylyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"ref-779329","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-11-S2-P206"},{"key":"ref-779330","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201329"},{"key":"ref-779331","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5349837"},{"key":"ref-779332","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket375"},{"key":"ref-779333","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203923"},{"key":"ref-779334","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket152"},{"key":"ref-779335","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.005686"},{"key":"ref-779336","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s13075-015-0723-1","article-title":"MRP8\/14 serum levels as a predictor of response to starting and stopping anti-TNF treatment in juvenile idiopathic arthritis","volume":"17","author":"Anink J","year":"2015","unstructured":"Anink J, Van Suijlekom-Smit LWA, Otten MH, . MRP8\/14 serum levels as a predictor of response to starting and stopping anti-TNF treatment in juvenile idiopathic arthritis. Arthritis Res Ther 2015; 17: 200.","journal-title":"Arthritis Res Ther"},{"key":"ref-779337","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200598"},{"key":"ref-779338","doi-asserted-by":"publisher","DOI":"10.1002\/art.40727"},{"key":"ref-779339","first-page":"1991","article-title":"Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban","volume":"25","author":"Petty RE","year":"1998","unstructured":"Petty RE, Southwood TR, Baum J, . Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban. J Rheumatol 1998; 25: 1991- 1994.","journal-title":"J Rheumatol"},{"key":"ref-779340","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis, second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","unstructured":"Petty RE, Southwood TR, Manners PS, . International League of Associations for Rheumatology classification of juvenile idiopathic arthritis, second revision, Edmonton, 2001. J Rheumatol 2004; 31: 390- 392.","journal-title":"J Rheumatol"},{"key":"ref-779341","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20497"},{"key":"ref-779342","first-page":"18","article-title":"Diagnostic and Predictive Role of Blood Calprotectin (MRP8\/MRP14) in Patients with Different Forms of Juvenile Idiopathic Arthritis","volume":"7","author":"Boyko JJ","year":"2016","unstructured":"Boyko JJ. Diagnostic and Predictive Role of Blood Calprotectin (MRP8\/MRP14) in Patients with Different Forms of Juvenile Idiopathic Arthritis. Zdorovie rebionka [Health of a Child] 2016; 7: 18- 24.","journal-title":"Zdorovie rebionka [Health of a Child]"},{"key":"ref-779343","doi-asserted-by":"publisher","DOI":"10.1002\/art.24349"},{"key":"ref-779344","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2017.66682"}],"container-title":["Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/reu.termedia.pl\/pdf-125486-85913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reu.termedia.pl\/pdf-125486-85913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T08:02:28Z","timestamp":1674806548000},"score":1,"resource":{"primary":{"URL":"https:\/\/reu.termedia.pl\/Blood-calprotectin-in-children-with-juvenile-idiopathic-arthritis-relationship-to,125486,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,31]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020]]}},"alternative-id":["125486"],"URL":"https:\/\/doi.org\/10.5114\/reum.2020.98431","relation":{},"ISSN":["0034-6233","2084-9834"],"issn-type":[{"value":"0034-6233","type":"print"},{"value":"2084-9834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,31]]}}}