{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:17:43Z","timestamp":1777709863938,"version":"3.51.4"},"reference-count":20,"publisher":"Termedia Sp. z.o.o.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"published-print":{"date-parts":[[2021,11,8]]},"abstract":"<jats:p>Pigmented villonodular synovitis (PVNS) is a\u00a0rare disease that has clinical and histopathological characteristics of both benign proliferative disorder and a\u00a0chronic inflammatory process of the synovial tissue. The primary mode of treatment is surgery followed by an adjuvant radiotherapy; however, the risk of recurrence is a\u00a0significant (40\u201370%). Several publications suggest that the TNF-\u03b1\u00a0inhibitors might be a\u00a0treatment option. We present a\u00a0case of a\u00a029-year-old female diagnosed with PVNS of the knee joint, refractory to surgery and 3 radionuclide synovectomies. Because the possibilities of conventional therapy were exhausted, treatment with an intra-articular anti-TNF-\u03b1\u00a0monoclonal antibody (infliximab) was performed. Despite a\u00a0high safety profile and a\u00a0good tolerance of that therapy we did not observe significant clinical and radiological improvement. To assess the effectiveness of intra-articular TNF-\u03b1\u00a0inhibitors as an adjuvant treatment in PVNS, prospective studies are needed.<\/jats:p>","DOI":"10.5114\/reum.2021.110601","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T09:21:11Z","timestamp":1636363271000},"page":"340-345","source":"Crossref","is-referenced-by-count":6,"title":["Is intra-articular infliximab therapy a good alternative to radionuclide synovectomy for a patient with refractory pigmented villonodular synovitis?"],"prefix":"10.5114","volume":"59","author":[{"given":"Anna","family":"Felis-Giemza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Apanel-Kotarska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Chojnowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzena","family":"Olesi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2021,11,7]]},"reference":[{"key":"ref-783861","doi-asserted-by":"publisher","DOI":"10.1080\/17453674.2017.1361126"},{"key":"ref-783862","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-015-0385-x"},{"key":"ref-783863","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507321103"},{"key":"ref-783864","doi-asserted-by":"publisher","DOI":"10.15557\/JoU.2018.0032"},{"key":"ref-783865","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.97B4.34907"},{"key":"ref-783866","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019856"},{"key":"ref-783867","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu230"},{"key":"ref-783868","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.025692"},{"key":"ref-783869","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12585"},{"key":"ref-783870","doi-asserted-by":"publisher","DOI":"10.1016\/j.eats.2017.06.029"},{"key":"ref-783871","doi-asserted-by":"publisher","DOI":"10.3881\/j.issn.1000-503X.2015.02.017"},{"key":"ref-783872","doi-asserted-by":"publisher","DOI":"10.4081\/reumatismo.2013.721"},{"key":"ref-783873","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-017-0634-1"},{"key":"ref-783874","first-page":"268","article-title":"[Intra-articular etanercept treatment for severe diffuse pigmented villonodular knee]","volume":"58","author":"Fiocco U","year":"2006","unstructured":"Fiocco U, Sfriso P, Oliviero F, et al. (2006). [Intra-articular etanercept treatment for severe diffuse pigmented villonodular knee] Reumatismo. 58: 268-274.","journal-title":"Reumatismo"},{"key":"ref-783875","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1185-z"},{"key":"ref-783876","volume-title":"StatPearls [Internet]","author":"Fecek C","year":"2021","unstructured":"Fecek C, Carter KR. (2021). StatPearls [Internet].  Stat. 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