{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T11:04:24Z","timestamp":1783249464132,"version":"3.54.6"},"reference-count":27,"publisher":"Termedia Sp. z.o.o.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"published-print":{"date-parts":[[2021,11,8]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients with seronegative spondyloarthritis (SpA) \u2013 psoriatic arthritis (PsA) and ankylosing spondylitis (AS) \u2013 have a\u00a0higher risk of cardiovascular morbidity and mortality. The aim of the present study was to evaluate the incidence and type of dyslipidemia, a\u00a0potent atherosclerosis risk factor, in SpA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>It was a\u00a0two-center, case-control study. Patients diagnosed with PsA and AS aged 23\u201360 years, with disease duration &lt; 10 years, were enrolled. The inflammatory activity, serum levels of C-reactive protein (CRP) and lipid profile were evaluated in each patient. In patients &gt; 40 years old, the 10-year risk of fatal cardiovascular disease (CVD), using Systematic Coronary Risk Evaluation (SCORE), was estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total 79 patients with SpA were included in the study, with PsA diagnosed, n = 39 (mean age 45.1 \u00b19.6 years; 21, 53.9%, women), and with AS diagnosed, n = 40 (age 40.3 \u00b19.5; 12.3%,  women), control group (CG): n = 88 (age 42.3 \u00b18.1; 42, 47.7% women). Based on the interview and laboratory tests, dyslipidemia was diagnosed in 19 (47.5%) patients with AS and in 28 (71.8%) patients with PsA. Most patients had hypercholesterolemia or mixed hyperlipidemia. Types of dyslipidemia were similar. In SpA patients (PsA and AS), the level of triglycerides (TG) and atherogenic index (AI) were significantly higher than in the CG, respectively TG in SpA: 116 (83\u2013156) and in the CG: 91.2 (72.6\u2013134.6) mg\/dl, p = 0.0182; AI in SpA: 3.77 \u00b11.26 and in the CG: 2.58 \u00b11.27, p &lt; 0.0001. The low-density cholesterol (LDL) level was significantly lower in SpA patients than in the CG, SpA: 109.1 \u00b129.4 vs. CG: 125.2 \u00b135.9 mg\/dl, p = 0.0023. There was a\u00a0strong negative correlation between CRP levels and HDL cholesterol levels in patients with PsA, rho = 0.42, p = 0.0132. Mean SCORE values were 2.33% in PsA patients and 2.38% in AS patients, which results in moderate  10-year risk of death from CVD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In young patients with spondyloarthropathies, inflammatory factors significantly influence dyslipidemia patterns, which result in higher TG and lower LDL cholesterol levels. In patients with PsA, dyslipidemia was diagnosed more often than in patients with AS.<\/jats:p><\/jats:sec>","DOI":"10.5114\/reum.2021.110610","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T09:21:11Z","timestamp":1636363271000},"page":"285-291","source":"Crossref","is-referenced-by-count":9,"title":["Patterns of dyslipidemia in young patients with seronegative spondyloarthropathies without cardiovascular diseases"],"prefix":"10.5114","volume":"59","author":[{"given":"Patrycja","family":"Ozdowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Kowalik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Sadowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Szwed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"G\u0142uszko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Rupi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brygida","family":"Kwiatkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Sikorska-Siudek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"D\u0105browski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2021,11,7]]},"reference":[{"key":"ref-783400","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133645"},{"key":"ref-783401","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-307838"},{"key":"ref-783402","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2004.07.010"},{"key":"ref-783403","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.151191"},{"key":"ref-783404","doi-asserted-by":"publisher","DOI":"10.1002\/art.24492"},{"key":"ref-783405","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20363"},{"key":"ref-783406","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.050443"},{"key":"ref-783407","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0380-5"},{"key":"ref-783408","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/839135"},{"key":"ref-783409","first-page":"2440","article-title":"Modest but sustained increase of serum high-density lipoprotein cholesterol levels in patients with inflammatory arthritides treated with infliximab","volume":"33","author":"Spanakis E","year":"2006","unstructured":"Spanakis E, Sidiropoulos P, Papadakis J, et al. (2006). Modest but sustained increase of serum high-density lipoprotein cholesterol levels in patients with inflammatory arthritides treated with infliximab J Rheumatol. 33: 2440-2446.","journal-title":"J Rheumatol"},{"key":"ref-783410","doi-asserted-by":"crossref","first-page":"11324","DOI":"10.3390\/ijms150711324","article-title":"Endothelial dysfunction in chronic inflammatory diseases","volume":"15","author":"Steyers CM","year":"2014","unstructured":"Steyers CM, Miller FJ Jr. (2014). Endothelial dysfunction in chronic inflammatory diseases Int J Mol Sci. 15: 11324-11349.","journal-title":"Int J Mol Sci"},{"key":"ref-783411","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"ref-783412","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133645"},{"key":"ref-783413","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"ref-783414","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"ref-783415","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2015.0182"},{"key":"ref-783416","first-page":"2167","article-title":"Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis","volume":"33","author":"Han C","year":"2006","unstructured":"Han C, Robinson DW Jr, Hackett MV, et al. (2006). Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis J Rheumatol. 33: 2167-2172.","journal-title":"J Rheumatol"},{"key":"ref-783417","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22185"},{"key":"ref-783418","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R300019-JLR200"},{"key":"ref-783419","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken090"},{"key":"ref-783420","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20364"},{"key":"ref-783421","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150193"},{"key":"ref-783422","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jbspin.2007.11.007","article-title":"No differences of carotid intima-media thickness between young patients with ankylosing spondylitis and healthy controls","volume":"75","author":"Choe JY","year":"2008","unstructured":"Choe JY, Lee MY, Rheem I, et al. (2008). No differences of carotid intima-media thickness between young patients with ankylosing spondylitis and healthy controls Joint Bone Spine. 75: 548-553.","journal-title":"Joint Bone Spine"},{"key":"ref-783423","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204933"},{"key":"ref-783424","first-page":"29","article-title":"M\u0142odzie\u0144cze spondyloartropatie","volume":"56","author":"Rutkowska-Sak L","year":"2010","unstructured":"Rutkowska-Sak L, S\u0142owi\u0144ska S, \u017buber Z. (2010). M\u0142odzie\u0144cze spondyloartropatie Ann Acad Med Stetin. 56: 29-33.","journal-title":"Ann Acad Med Stetin"},{"key":"ref-783425","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei145"},{"key":"ref-783426","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2016.0029"}],"container-title":["Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/reu.termedia.pl\/pdf-142779-86005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reu.termedia.pl\/pdf-142779-86005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T08:00:06Z","timestamp":1674806406000},"score":1,"resource":{"primary":{"URL":"https:\/\/reu.termedia.pl\/Patterns-of-dyslipidemia-in-young-patients-with-seronegative-spondyloarthropathies,142779,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,7]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021]]}},"alternative-id":["142779"],"URL":"https:\/\/doi.org\/10.5114\/reum.2021.110610","relation":{},"ISSN":["0034-6233","2084-9834"],"issn-type":[{"value":"0034-6233","type":"print"},{"value":"2084-9834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,7]]}}}