{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:31:32Z","timestamp":1784302292020,"version":"3.55.0"},"reference-count":13,"publisher":"Termedia Sp. z.o.o.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatologia"],"published-print":{"date-parts":[[2022,7,4]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>In this study, we aimed to determine the\u00a0frequency of\u00a0MEFV mutations in Beh\u00e7et\u2019s disease (BD) and to investigate the\u00a0relationship between clinical findings of\u00a0the\u00a0disease and the\u00a0MEFV mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A\u00a0total of\u00a066 participants (30 BD patients, 36 healthy subjects) were included in this study. The MEFV gene was analyzed by using DNA sequence analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The\u00a0distribution of\u00a0MEFV mutations was not significantly different between the patients and the control group (p\u00a0=\u00a00.373). However, individuals with R202Q mutation had a\u00a0risk of\u00a0OR\u00a04 times (95% CI: 1.1\u201314.5) higher than those without the\u00a0mutation (p\u00a0=\u00a00.035). The rate of vascular involvement was statistically significantly higher in patients with the mutation than in patients without the mutation (p = 0.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MEFV mutation was associated with vascular involvement in patients with BD. This is also the\u00a0first study to indicate that the\u00a0R202Q mutation may have a\u00a0role in BD. However large series from different regions are required to compare these results.<\/jats:p><\/jats:sec>","DOI":"10.5114\/reum.2022.117843","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T11:52:31Z","timestamp":1657713151000},"page":"220-223","source":"Crossref","is-referenced-by-count":4,"title":["Association of MEFV mutations and vascular involvement in Behcet\u2019s disease: a study from Hatay, Turkey"],"prefix":"10.5114","volume":"60","author":[{"given":"Gamze","family":"Serarslan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel","family":"Cura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gezmi\u015f","family":"Kimyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"\u00dc\u00e7g\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Karada\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"ref-786594","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01067"},{"key":"ref-786595","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1809-100"},{"key":"ref-786596","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200674"},{"key":"ref-786597","doi-asserted-by":"publisher","DOI":"10.1016\/s0049-0172(00)80015-3"},{"key":"ref-786598","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1004(200009)16:3<271::AID-HUMU16>3.0.CO;2-A"},{"key":"ref-786599","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2016.10.011"},{"key":"ref-786600","first-page":"1078","article-title":"International Study Group for Beh\u00e7et\u2019s Disease","volume":"335","author":"Criteria for","year":"1990","unstructured":"Criteria for diagnosis of Beh\u00e7et\u2019s disease.  International Study Group for Beh\u00e7et\u2019s Disease.  Lancet1990;  335: 1078\u2013 1080 [No authors listed].","journal-title":"Lancet"},{"key":"ref-786601","doi-asserted-by":"publisher","DOI":"10.1080\/03009740510017931"},{"key":"ref-786602","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306352110"},{"key":"ref-786603","first-page":"S35","article-title":"MEFV mutations are increaed in Beh\u00e7et\u2019s disease (BD) and are associated with vascular involvement","volume":"21","author":"Atagunduz P","year":"2003","unstructured":"Atagunduz P, Ergun T, Direskeneli H. MEFV mutations are increaed in Beh\u00e7et\u2019s disease (BD) and are associated with vascular involvement.  Clin Exp Rheumatol 2003,  21 ( Suppl 30):  S35\u2013 S37.","journal-title":"Clin Exp Rheumatol"},{"key":"ref-786604","first-page":"S24","article-title":"MEFV, TNFRSF1A and CARD15 mutation analysis in Beh\u00e7et\u2019s disease","volume":"29","author":"Baruch Y","year":"2011","unstructured":"Baruch Y, Dagan E, Rosner I, . MEFV, TNFRSF1A and CARD15 mutation analysis in Beh\u00e7et\u2019s disease.  Clin Exp Rheumatol 2011;  29 ( Suppl 67):  S24\u2013 S27.","journal-title":"Clin Exp Rheumatol"},{"key":"ref-786605","first-page":"530","article-title":"Familial mediterranean fever and Beh\u00e7et\u2019s disease \u2013 are they associated?","volume":"29","author":"Ben-Chetrit E","year":"2002","unstructured":"Ben-Chetrit E, Cohen R, Chajek-Shaul T. Familial mediterranean fever and Beh\u00e7et\u2019s disease \u2013 are they associated? J Rheumatol 2002;  29: 530\u2013 534.","journal-title":"J Rheumatol"},{"key":"ref-786606","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39113-5"}],"container-title":["Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/reu.termedia.pl\/pdf-151514-86063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reu.termedia.pl\/pdf-151514-86063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T07:56:39Z","timestamp":1674806199000},"score":1,"resource":{"primary":{"URL":"https:\/\/reu.termedia.pl\/Association-of-MEFV-mutations-and-vascular-involvement-in-Behcet-s-disease-a-study,151514,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,4]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"alternative-id":["151514"],"URL":"https:\/\/doi.org\/10.5114\/reum.2022.117843","relation":{},"ISSN":["0034-6233","2084-9834"],"issn-type":[{"value":"0034-6233","type":"print"},{"value":"2084-9834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,4]]}}}