{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:52:20Z","timestamp":1771231940653,"version":"3.50.1"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2021,3,22]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology which causes progressive deterioration\nof the joints, leading to severe pain and functional disability. Vitamin D and\nits receptor (VDR) play a significant part in the onset of autoimmune diseases such as RA. The purpose of this study was to evaluate the association\nbetween VDR gene polymorphisms and risk of developing RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A  retrospective study was performed, including\n214 RA cases and 748 controls of Caucasian origin. FokI (rs2228570), BsmI\n(rs1544410), TaqI (rs731236), ApaI (rs7975232) and Cdx2 (rs11568820) gene\npolymorphisms were analyzed by TaqMan<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The recessive logistic regression model showed that the VDR FokIAA genotype was associated with lower risk of RA (p = 0.0255; OR = 0.58;\n95% CI: 0.35\u20130.92). No other genetic polymorphism showed any association with RA in any of the models tested. Haplotype analysis revealed that\nthe haplotypes ACGAG (p = 0.033; OR = 1.62; 95% CI: 1.04\u20132.53) and GTGCA\n(p &lt; 0.01; OR = 2.77; 95% CI: 1.53\u20134.98) for BsmI, Cdx2, FokI, ApaI and TaqI\nwere associated with higher risk of RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>VDR FokI gene polymorphism showed a  trend for risk of  RA,\ntaking into account the variables of gender, age and tobacco use, and preventing false positives. Among our patients we found no influence of VDR\nBsmI, TaqI, ApaI and Cdx2 on the risk of developing RA. However, haplotype\nanalysis indicated that the haplotypes ACGAG and GTGCA were associated\nwith higher risk of RA.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms\/116606","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T22:03:38Z","timestamp":1616450618000},"source":"Crossref","is-referenced-by-count":7,"title":["Association of vitamin D receptor gene polymorphisms\nwith rheumatoid arthritis"],"prefix":"10.5114","author":[{"given":"Noelia","family":"Marquez Pete","sequence":"first","affiliation":[{"name":"Pharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves,\nUGC Provincial de Farmacia de Granada, Granada, Spain"}]},{"given":"Cristina","family":"Perez Ramirez","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves,\nUGC Provincial de Farmacia de Granada, Granada, Spain"},{"name":"Department of Social Pharmacy, Faculty of Pharmacy, University of Lisbon, Lisbon,\nPortugal"},{"name":"Department of Biochemistry, Faculty of Pharmacy, University of Granada, Granada,\nSpain"}]},{"given":"Maria del Mar","family":"Maldonado Montoro","sequence":"additional","affiliation":[{"name":"Clinical Analysis Service, Hospital Campus de la Salud, Granada, Spain"}]},{"given":"Fernando","family":"Martinez Martinez","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, Faculty of Pharmacy, University of Granada,\nGranada, Spain"}]},{"given":"Fernando","family":"Fern\u00e1ndez-Llimos","sequence":"additional","affiliation":[{"name":"Department of Social Pharmacy, Faculty of Pharmacy, University of Lisbon, Lisbon,\nPortugal"}]},{"given":"Antonio","family":"S\u00e1nchez Pozo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, University of Granada, Granada,\nSpain"}]},{"given":"Mar\u00eda del Carmen","family":"Ramirez Tortosa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, University of Granada, Granada,\nSpain"}]},{"given":"Alberto","family":"Jim\u00e9nez Morales","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves,\nUGC Provincial de Farmacia de Granada, Granada, Spain"}]}],"member":"3061","published-online":{"date-parts":[[2021,3,22]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-116606-62989","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-116606-62989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T14:20:01Z","timestamp":1635517201000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Association-of-vitamin-D-receptor-gene-polymorphisms-nwith-rheumatoid-arthritis,116606,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,22]]},"references-count":0,"alternative-id":["116606"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/116606","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,22]]}}}