{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:51:13Z","timestamp":1782283873129,"version":"3.54.5"},"reference-count":84,"publisher":"Korean Association of Anatomists","issue":"2","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acbjournal.org"],"crossmark-restriction":true},"short-container-title":["Anat Cell Biol"],"published-print":{"date-parts":[[2026,6,30]]},"DOI":"10.5115\/acb.25.347","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:19:11Z","timestamp":1778224751000},"page":"207-218","update-policy":"https:\/\/doi.org\/10.5115\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive review of the cerebral aqueduct: anatomy, embryology, imaging, genetics, molecular, and pathology"],"prefix":"10.5115","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9295-2935","authenticated-orcid":false,"given":"Gabrielle","family":"Dituri","sequence":"first","affiliation":[{"name":"Tulane University School of Medicine, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9521-9878","authenticated-orcid":false,"given":"Noritaka","family":"Komune","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-9703","authenticated-orcid":false,"given":"Nicol\u00e1s E.","family":"Ottone","sequence":"additional","affiliation":[{"name":"Laboratory of Plastination and Anatomical Techniques, Universidad de La Frontera, Temuco, Chile"},{"name":"Department of Integral Adults Odontology, Centre for Research in Dental Sciences (CICO), Dental School, Universidad de La Frontera, Temuco, Chile"},{"name":"Center of Excellence in Morphological and Surgical Studies (CEMyQ), School of Medicine, Universidad de La Frontera, Temuco, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4419-6255","authenticated-orcid":false,"given":"Nikola","family":"Vu\u010dini\u0107","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-8158","authenticated-orcid":false,"given":"Carmine Antonio","family":"Donofrio","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, ASST Cremona, Cremona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0041-0945","authenticated-orcid":false,"given":"Filippo","family":"Badaloni","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6205-3744","authenticated-orcid":false,"given":"Antonio","family":"Fioravanti","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, ASST Cremona, Cremona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8502-7952","authenticated-orcid":false,"given":"Joe","family":"Iwanaga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA"},{"name":"Department of Neurology, Tulane University School of Medicine, New Orleans, LA, USA"},{"name":"Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA, USA"},{"name":"Department of Neurosurgery and Ochsner Neuroscience Institute, Ochsner Health System, New Orleans, LA, USA"},{"name":"Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5760-1382","authenticated-orcid":false,"given":"C. J.","family":"Bui","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Ochsner Neuroscience Institute, Ochsner Health System, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5289-7011","authenticated-orcid":false,"given":"Joseph","family":"Lockwood","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8077-8992","authenticated-orcid":false,"given":"Aaron S.","family":"Dumont","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1317-1047","authenticated-orcid":false,"given":"R. Shane","family":"Tubbs","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA"},{"name":"Department of Neurology, Tulane University School of Medicine, New Orleans, LA, USA"},{"name":"Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA, USA"},{"name":"Department of Neurosurgery and Ochsner Neuroscience Institute, Ochsner Health System, New Orleans, LA, USA"},{"name":"Department of Otolaryngology, Tulane University School of Medicine, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3054","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-014-2431-6"},{"key":"ref2","unstructured":"Franciscus Sylvius [Internet]. Wellcome Collection; 1973 [cited 2025 Sep 12]. Available from: https:\/\/wellcomecollection.org\/works\/rv4evxja"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-31889-9_19-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/B0-12-227210-2\/00356-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2022.07.036"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000146420"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2298\/MPNS0512534S"},{"key":"ref8","unstructured":"Gilbert SF. Formation of the neural tube. In: Gilbert SF, editor. Developmental Biology. 6th ed. Sunderland; 2000."},{"key":"ref9","unstructured":"Singh R, Munakomi S. Embryology, neural tube [Internet]. StatPearls Publishing; 2023 [cited 2025 Sep 12]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK542285\/"},{"key":"ref10","unstructured":"Sadler TW. Langman's medical embryology. 12th ed. Lippincott Williams & Wilkins; 2012."},{"key":"ref11","unstructured":"Hochstetter F. [Beitr\u00e4ge zur Entwicklungsgeschichte des menschlichen Gehirns]. Deuticke, 1929."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-013-2321-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01639-x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2021.703835"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1242\/dev.175794"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.05.080"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394307-1.00002-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0029(20010301)52:5<591::AID-JEMT1043>3.0.CO;2-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8454-5-3"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-819507-9.00022-3"},{"key":"ref21","unstructured":"Javed K, Reddy V, Lui F. Neuroanatomy, choroid plexus [Internet]. StatPearls Publishing; 2023 [cited 2025 Sep 12]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538156\/"},{"key":"ref22","unstructured":"Rubino JM, Hogg JP. Neuroanatomy, cerebral aqueduct (Sylvian) [Internet]. StatPearls Publishing; 2023 [cited 2025 Sep 12]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK540988\/"},{"key":"ref23","unstructured":"Margetis K, Baker S. Physiology, cerebral spinal fluid [Internet]. StatPearls Publishing; 2025 [cited 2025 Sep 12]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519007\/"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6413-x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/BF00588270"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4124"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-10-36"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25160"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.5233"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2007.12.021"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600462"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3390\/app9102131"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-019-0159-0"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002\/bies.200800207"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-021-05408-0"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/BF00341738"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1308"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10088"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-817424-1.00009-4"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23606"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2011.05.010"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2003.00124.x"},{"key":"ref43","unstructured":"Mayo Clinic. Hydrocephalus [Internet]. Mayo Clinic; c1998-2026 [cited 2025 Sep 12]. Available from: https:\/\/www.mayoclinic.org\/diseases-conditions\/hydrocephalus\/symptoms-causes\/syc-20373604."},{"key":"ref44","unstructured":"Park JJ, Park BH, Lee HS, Lee JS. A Parkinsonism as a component of Sylvian aqueduct syndrome: effect of floating cranioplasty and distal catheter elongation. J Korean Neurosurg Soc 2006;39:438-42."},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.37.1.21"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.38.3.288"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-024-06645-9"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.11.096"},{"key":"ref49","unstructured":"UCLA Health. Cavernous angioma [Internet]. UCLA Health; c2025 [cited 2025 Oct 9]. Available from: https:\/\/www.uclahealth.org\/medical-services\/neurosurgery\/conditions-treated\/cavernous-angioma"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.4103\/sni.sni_165_17"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2024.02.023"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870929"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/B0-12-227210-2\/00170-9"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-015-2827-y"},{"key":"ref55","unstructured":"Kuhn J, Weisbrod LJ, Emmady PD. Chiari malformation type 2 [Internet]. StatPearls Publishing; 2024 [cited 2025 Sep 12]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557498\/"},{"key":"ref56","unstructured":"National Institute of Neurological Disorders and Stroke. Chiari malformations [Internet]. National Institutes of Health; 2025 [cited 2025 Oct 9]. Available from: https:\/\/www.ninds.nih.gov\/health-information\/disorders\/chiari-malformations"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.134.3.6965544"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1101\/gad.349358.122"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-003-2127-5"},{"key":"ref60","unstructured":"Zamora EA, Das JM, Ahmad T. Dandy-Walker malformation [Internet]. StatPearls Publishing; 2023 [cited 2025 Sep 12]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538197\/"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53486-6.00058-2"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-024-00513-z"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-070815-014023"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/B0-12-227210-2\/00152-7"},{"key":"ref65","unstructured":"Arienta C, Cappricci E, Baiguini M. Non tumoral aqueduct stenosis. Multiple microscopic subependymal glial protuberances demonstrated at histological examination. J Neurosurg Sci 1986;30:67-70."},{"key":"ref66","unstructured":"O'Callaghan WJ, Robertson DM. Gliosis of the aqueduct. Can Med Assoc J 1966;95:1260-3."},{"key":"ref67","unstructured":"Russell DS. Observations on the pathology of hydrocephalus. Her Majesty's Stationery Office; 1949."},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-003-0805-2"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.3171\/CASE24695"},{"key":"ref70","unstructured":"Fowler JB, De Jesus O, Mesfin FB. Ventriculoperitoneal shunt [Internet]. StatPearls Publishing; 2023 [cited 2025 Sep 12]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459351\/"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.3171\/ped.2005.103.5.0388"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-006-0227-z"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-27250-4_80"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2012.02.013"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-023-06171-0"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1080\/02688697.2016.1245848"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.4103\/0976-3147.98222"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.3171\/2011.4.PEDS10503"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1186\/s41016-020-00228-8"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.04.255"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1002\/ca.24258"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1002\/ca.70007"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1002\/ca.24293"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1002\/ca.24156"}],"container-title":["Anatomy &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/ACB\/2026\/059\/acb-59-2-207.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/pdf.medrang.co.kr\/ACB\/2026\/059\/acb-59-2-207.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:37:40Z","timestamp":1782283060000},"score":1,"resource":{"primary":{"URL":"https:\/\/acbjournal.org\/journal\/view.html?doi=10.5115\/acb.25.347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":84,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6,30]]}},"alternative-id":["10.5115\/acb.25.347"],"URL":"https:\/\/doi.org\/10.5115\/acb.25.347","relation":{},"ISSN":["2093-3665","2093-3673"],"issn-type":[{"value":"2093-3665","type":"print"},{"value":"2093-3673","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"https:\/\/acbjournal.org\/journal\/view.html?doi=10.5115\/acb.25.347","URL":"https:\/\/acbjournal.org\/journal\/view.html?doi=10.5115\/acb.25.347","name":"the_journal","label":"Anat Cell Biol","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2025-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":3,"name":"published","label":"Online First","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":4,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2026 The Korean Association of Anatomists","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}