{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:31:02Z","timestamp":1778509862575,"version":"3.51.4"},"reference-count":42,"publisher":"King Faisal Specialist Hospital and Research Centre","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Saudi Med"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Gene-disease association between human leukocyte antigen (HLA)-C locus polymorphism and psoriatic arthritis (PsA) remains controversial.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVE:<\/jats:title>\n            <jats:p>Evaluate the relationship between HLA-C locus polymorphism and PsA in populations of European and Middle Eastern descent.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SEARCH METHODS:<\/jats:title>\n            <jats:p>PubMed, PMC, Elsevier and Google Scholar databases from 1980 to January 2020. The search was limited to articles in English.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SELECTION CRITERIA:<\/jats:title>\n            <jats:p>Case-control studies (with unrelated participants) that had allele\/genotype data on the association between HLA-C locus polymorphism and PsA susceptibility.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>DATA COLLECTION AND ANALYSIS:<\/jats:title>\n            <jats:p>Two investigators searched independently in searching the literature. Disagreements were resolved by discussion and consultation with a third researcher. The Q-Genie tool was used to assess the quality of articles.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Twenty-five studies met the inclusion criteria. At the allelic level, three alleles were associated with an increased risk of PsA and five were associated with a reduced risk. At the phenotypic level, four alleles were associated with increased risk of PsA and three were associated with a reduced risk. At both the allelic and phenotypic levels, the results revealed that HLA-C*04 played a protective role in PsA (The pooled odds ratio [OR] is 0.66 for allelic level and 0.63 for phenotypic level), while HLA-C*02, *06 and *12 increased the risk of suffering from PsA (The pooled ORs of C*02, *06 and *12 are 2.21, 2.63 and 1.49 for allelic level, and 1.79, 2.96 and 2.25 for phenotypic level, respectively).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION:<\/jats:title>\n            <jats:p>The pooled results showed a significant association between PsA and the HLA-C gene in populations of European and Middle Eastern descent. At both the allelic and phenotypic levels, the HLA-C*02, *06 and *12 may contribute to susceptibility to PsA, while HLA-C*04 may confer a protective role against PsA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>Not registered.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONFLICT OF INTEREST:<\/jats:title>\n            <jats:p>None.<\/jats:p>\n          <\/jats:sec>","DOI":"10.5144\/0256-4947.2020.338","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T16:39:28Z","timestamp":1596731968000},"page":"338-346","source":"Crossref","is-referenced-by-count":7,"title":["Associations between human leukocyte antigen C locus polymorphism and psoriatic arthritis in populations of European and Middle Eastern descent: a meta-analysis"],"prefix":"10.5144","volume":"40","author":[{"given":"Lin-Nan","family":"Shao","sequence":"first","affiliation":[{"name":"From the Blood Group, Balian Blood Center, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Blood Group, Balian Blood Center, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Hang","family":"Zhou","sequence":"additional","affiliation":[{"name":"From the Blood Group, Balian Blood Center, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1088-3973","authenticated-orcid":true,"given":"Zi","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Sports Medicine, Dalian Municipal Central Hospital, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3134","reference":[{"issue":"10","key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1136\/annrheumdis-2017-211414","article-title":"Cross-phenotype association mapping of the MHC identifies genetic variants that differentiate psoriatic arthritis from psoriasis","volume":"76","author":"Bowes J","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.semarthrit.2018.01.003","article-title":"Prevalence and incidence of psoriatic arthritis: A systematic review and meta-analysis","volume":"48","author":"Scotti L","year":"2018","journal-title":"Semin Arthritis Rheum"},{"issue":"9","key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1002\/acr.22831","article-title":"Global Prevalence of Spondyloarthritis: A Systematic Review and Meta-Regression Analysis","volume":"68","author":"Stolwijk C","year":"2016","journal-title":"Arthritis Care Res"},{"key":"e_1_3_1_5_2","first-page":"ii14","article-title":"Psoriatic arthritis: epidemiology, clinical features, course, and outcome","volume":"64","author":"Gladman DD","year":"2005","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"e_1_3_1_6_2","first-page":"86","article-title":"Healthcare and burden of disease in psoriatic arthritis. 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