{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:52:21Z","timestamp":1774569141517,"version":"3.50.1"},"reference-count":16,"publisher":"King Faisal Specialist Hospital and Research Centre","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Saudi Med"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>In 2015, multiple myeloma (MM) represented 1% of all cancers and about 5% of hematologic malignancies in Saudi cancer registry. We conducted this large study because only small pilot studies have examined MM outcomes after autologous stem-cell transplantation (ASCT). The standard therapy for eligible patients is induction chemotherapy followed by ASCT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVES:<\/jats:title>\n            <jats:p>Determine the demographic characteristics of MM patients and the outcomes of ASCT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>DESIGN:<\/jats:title>\n            <jats:p>Retrospective.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SETTING:<\/jats:title>\n            <jats:p>Tumor registry database of major tertiary cancer care center in Riyadh.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS AND METHODS:<\/jats:title>\n            <jats:p>We identified patients with newly diagnosed MM who underwent ASCT from October 1997 to March 2015.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MAIN OUTCOME MEASURES:<\/jats:title>\n            <jats:p>The demographic characteristics of MM patients and the outcomes of ASCT in the form of response evaluation, progression-free survival (PFS) and overall survival (OS).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SAMPLE SIZE:<\/jats:title>\n            <jats:p>169 patients with newly diagnosed MM.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>The median age at diagnosis was 51 years (range 23\u201369) and 100 (59.2%) were male. The most common immunoglobulin (Ig) subtype was IgG-kappa (80 patients; 47.6%). Most patients presented with advanced ISS stage III (75 patients; 47.5%). The cytogenetic analysis was documented in only 87 patients (51.4%); about half (48.3%) had normal cytogenetics by fluorescence in situ hybridization. Deletion 13 was present in 18.4% of patients. In post-induction therapy, 84 patients (50%) achieved a complete response, which increased to 78.1% (132 patients) after ASCT. The median PFS and OS post-transplantation were 30 and 202 months, respectively. Only one patient (&lt;1%) died in the first 100 days after transplantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Our transplant eligible MM patients tend to be younger with a higher OS and a low ASCT-related mortality (&lt;1%) than is reported internationally.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>LIMITATIONS:<\/jats:title>\n            <jats:p>Usual limitations of a retrospective analysis using registry-level data; no data on quality of life.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONFLICTS OF INTEREST:<\/jats:title>\n            <jats:p>None.<\/jats:p>\n          <\/jats:sec>","DOI":"10.5144\/0256-4947.2021.198","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T12:42:44Z","timestamp":1636893764000},"page":"198-205","source":"Crossref","is-referenced-by-count":12,"title":["Outcomes of autologous stem cell transplantation for multiple myeloma in Saudi Arabia"],"prefix":"10.5144","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0800-990X","authenticated-orcid":true,"given":"Ahmed Kotb","family":"Abdrabou","sequence":"first","affiliation":[{"name":"From the Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"},{"name":"From the Department of Medicine, Hematology Unit, Zagazig University, Zagazig, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahad Al","family":"Sharif","sequence":"additional","affiliation":[{"name":"From the Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi 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