{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:49:32Z","timestamp":1780541372266,"version":"3.54.1"},"reference-count":18,"publisher":"King Faisal Specialist Hospital and Research Centre","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Saudi Med"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n            We report a 38-year-old woman who presented with a subdural hematoma after minor facial trauma in a stressful situation. The laboratory data showed a subnormal platelet count (166\u00d710\n            <jats:sup>9<\/jats:sup>\n            \/L), VWF:RCo activity was 45% and VWF:Ag was 53% with a VWF:RCo\/VWF Ag ratio of 0.79. Hemostasis results and gene analysis revealed von Willebrand disease (VWD) type 2B with normal multimers and a novel mutation c.4136 G&gt;T (R1379L), which appears to be a novel mutation of VWD type 2B that is mainly diagnosed with hypersensitivity to ristocetin and an hyperfixation of platelet Willebrand to a recombinant Gp1b.\n          <\/jats:p>\n          <jats:sec>\n            <jats:title>SIMILAR CASES PUBLISHED:<\/jats:title>\n            <jats:p>None.<\/jats:p>\n          <\/jats:sec>","DOI":"10.5144\/0256-4947.2021.59","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T21:07:25Z","timestamp":1612818445000},"page":"59-61","source":"Crossref","is-referenced-by-count":3,"title":["Von Willebrand disease type 2B with a novel mutation in the VWF gene"],"prefix":"10.5144","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5428-9167","authenticated-orcid":true,"given":"Mohammed Abdullah","family":"Jeraiby","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Faculty of Medicine, Jazan University, Prince Muhammed Bin Naser Hospital, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susen","family":"Sophie","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Regional and University Hospital Centre Lille, Lille, Hauts-de-France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Caron","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Regional and University Hospital Centre Lille, Lille, Hauts-de-France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Campos","sequence":"additional","affiliation":[{"name":"From the Department of hematology, CHU Saint-Etienne, Sant Etienne, Rhone-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tardy","family":"Brigitte","sequence":"additional","affiliation":[{"name":"From the Department of hematology, CHU Saint-Etienne, Sant Etienne, Rhone-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3134","reference":[{"issue":"1","key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1538-7836.2003.00523.x","article-title":"Type IIB von Willebrand disease: A paradox explains how von Willebrand factor works","volume":"2","author":"Ruggeri ZM","year":"2004","unstructured":"Ruggeri ZM. 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