{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:05:46Z","timestamp":1773097546927,"version":"3.50.1"},"reference-count":16,"publisher":"King Faisal Specialist Hospital and Research Centre","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Saudi Med"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>\n              Thyrotoxicosis is a common medical problem. Thyroid nuclear imaging with either I\n              <jats:sup>123<\/jats:sup>\n              or technetium-99m (Tc-99m) pertechnetate are used to determine the cause. Although I\n              <jats:sup>123<\/jats:sup>\n              has been the standard technique, Tc-99m pertechnetate is now commonly used, acceptable and easier to perform. The commonly used normal value of Tc-99m pertechnetate is 1\u20134%, but lower normal values have been reported in different populations.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVE:<\/jats:title>\n            <jats:p>Determine normal reference range of Tc-99m pertechne-tate thyroid uptake for thyroid scintigraphy in Saudi Arabia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>DESIGN:<\/jats:title>\n            <jats:p>Retrospective, cross-sectional.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SETTING:<\/jats:title>\n            <jats:p>Nuclear medicine service at tertiary care center in Riyadh.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS AND METHODS:<\/jats:title>\n            <jats:p>We used data from biochemically euthyroid patients who underwent a thyroid Tc-99m pertechnetate scan while having parathyroid scintigraphy for hyperparathyroidism between April 2009 to April 2019. Medical records and biochemical thyroid function tests were reviewed and Tc-99m pertechnetate thyroid uptake values were determined for each patient.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MAIN OUTCOME MEASURES:<\/jats:title>\n            <jats:p>Thyroid uptake of Tc-99m pertechne-tate in euthyroid patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SAMPLE SIZE:<\/jats:title>\n            <jats:p>167<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              The mean and median uptake of Tc-99m pertechnetate in euthyroid patients were 0.86% and 1.0%, respectively, and the inter-quartile range was 0.0\u20131.0%. The normal reference range in the study population was 0.2-2%. Thyroid uptake inversely correlated with age in females (r=\u22120.37,\n              <jats:italic>P<\/jats:italic>\n              &lt;.001), males (r=\u22120.46,\n              <jats:italic>P<\/jats:italic>\n              =.001), and for all patients (r=?0.39,\n              <jats:italic>P<\/jats:italic>\n              &lt;.0001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION:<\/jats:title>\n            <jats:p>The range for normal thyroid Tc-99m pertechnetate was lower than the standard 1-4% range. Moreover, uptake decreased with age. Further studies are needed to establish the normal age-adjusted uptake for the thyroid Tc-99m pertechnetate scan.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>LIMITATIONS:<\/jats:title>\n            <jats:p>Single center and retrospective.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONFLICT OF INTEREST:<\/jats:title>\n            <jats:p>None.<\/jats:p>\n          <\/jats:sec>","DOI":"10.5144\/0256-4947.2021.86","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T12:14:36Z","timestamp":1617624876000},"page":"86-90","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of normal reference values for thyroid uptake of technetium-99m pertechnetate in a Saudi population"],"prefix":"10.5144","volume":"41","author":[{"given":"Awad","family":"Alshahrani","sequence":"first","affiliation":[{"name":"From the Department of Medicine, National Guard Health Affairs, Riyadh, Saudi Arabia"},{"name":"From the King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"},{"name":"From the College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulam M.","family":"Syed","sequence":"additional","affiliation":[{"name":"From the Nuclear Medicine and PET\/CT Center, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Altaf H.","family":"Khan","sequence":"additional","affiliation":[{"name":"From the King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shah P.","family":"Numani","sequence":"additional","affiliation":[{"name":"From the Nuclear Medicine and PET\/CT Center, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz","family":"Alnaim","sequence":"additional","affiliation":[{"name":"From the Polyclinic Center, King Faisal University, Al Hasa, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Alanazi","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Majmaah University College of Medicine, Al Majmaah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6796-9428","authenticated-orcid":true,"given":"Moeber M.","family":"Mahzari","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, National Guard Health Affairs, Riyadh, Saudi Arabia"},{"name":"From the King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"},{"name":"From the College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3134","reference":[{"issue":"10","key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/thy.2016.0229","article-title":"2016 american thyroid association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis","volume":"26","author":"Ross DS","year":"2016","unstructured":"Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, Rivkees SA, Samuels M, Sosa JA, Stan MN. 2016 american thyroid association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. 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Asia Oceania Journal of Nuclear Medicine and Biology [Internet]. 2020;8(1):54.","journal-title":"Asia Oceania Journal of Nuclear Medicine and Biology [Internet]."}],"container-title":["Annals of Saudi Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T11:52:45Z","timestamp":1618228365000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.annsaudimed.net\/doi\/10.5144\/0256-4947.2021.86"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.5144\/0256-4947.2021.86"],"URL":"https:\/\/doi.org\/10.5144\/0256-4947.2021.86","relation":{},"ISSN":["0256-4947","0975-4466"],"issn-type":[{"value":"0256-4947","type":"print"},{"value":"0975-4466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}