{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:57:22Z","timestamp":1772503042515,"version":"3.50.1"},"reference-count":38,"publisher":"King Faisal Specialist Hospital and Research Centre","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Saudi Med"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Prescribing habits during admission have largely contributed to the opioid epidemic. Orthopedic surgeons represent the third-highest opioid-prescribing specialty. Since more than half of body fractures in Saudi Arabia have been lower extremity fractures, it is imperative to understand opioid administration patterns and correlates among opioid-na\u00efve inpatients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVES:<\/jats:title>\n            <jats:p>Assess opioid administration patterns and correlates among opioid-na\u00efve inpatients with lower extremity fractures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>DESIGN AND SETTINGS:<\/jats:title>\n            <jats:p>Retrospective cohort<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS AND METHODS:<\/jats:title>\n            <jats:p>Opioid na\u00efve individuals aged 18 to 64 years, admitted due to lower extremity fracture from 2016 to 2020 were included. Data was collected from health records of the Ministry of National Guard Health Affairs (MNG-HA) at five different medical centers. The high-dose (\u226550 MME) patients were compared with low dose (&lt;50 MME) patients. Any association between inpatient factors and high-dose opioid use was analyzed by multiple logistic regression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MAIN OUTCOME MEASURES:<\/jats:title>\n            <jats:p>Opioids taken during inpatient admission as measured by milligram morphine equivalents (MME)\/per day.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SAMPLE SIZE:<\/jats:title>\n            <jats:p>1520 patients<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Most of the 1520 patients (88.5%) received an opioid medication, while (20.3%) received high-dose opioids at a median daily dose of 33.7 MME\/per day. The proportion of patients received naloxone (20.7%) was double among high-dose opioid inpatients. High-dose opioid patients during admission were two times more likely to receive an opioid prescription after discharge (odds ratio, 2.32; 95% confidence interval, 1.53, 3.51), and three more times likely to receive ketamine during admission (odds ratio, 3.02; 95% confidence interval, 1.64, 5.54).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION:<\/jats:title>\n            <jats:p>Notable variabilities exist in opioid administration patterns that were not explained by patient factors. Evidence-based opioid prescribing practices should be developed for orthopedic patients to prevent opioid overprescribing and potential opioid overdose among orthopedic patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>LIMITATIONS:<\/jats:title>\n            <jats:p>Retrospective, unmeasurable confounders might have biased our results. Since based on National Guard employees, results may not be generalizable.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONFLICT OF INTEREST:<\/jats:title>\n            <jats:p>None.<\/jats:p>\n          <\/jats:sec>","DOI":"10.5144\/0256-4947.2022.366","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T12:09:44Z","timestamp":1669723784000},"page":"366-376","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of opioid administration patterns following lower extremity fracture among opioid-na\u00efve inpatients: retrospective multicenter cohort study"],"prefix":"10.5144","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-2155","authenticated-orcid":true,"given":"Majed","family":"Ramadan","sequence":"first","affiliation":[{"name":"From the Population Health, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahya","family":"Alnashri","sequence":"additional","affiliation":[{"name":"From the Department of Family and Community Medicine, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amjad","family":"Ilyas","sequence":"additional","affiliation":[{"name":"From the Department of Orthopedic Surgery, Dr. Soliman Fakeeh Hospital, Makkah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Batouk","sequence":"additional","affiliation":[{"name":"From the Department of Surgery, King Khalid National Guard Hospital, Makkah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid A.","family":"Alsheikh","sequence":"additional","affiliation":[{"name":"From the College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Alhelabi","sequence":"additional","affiliation":[{"name":"From the Population Health, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suliman Abdulah","family":"Alnashri","sequence":"additional","affiliation":[{"name":"From the Population Health, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3134","reference":[{"issue":"10028","key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(16)00161-6","article-title":"Use of and barriers to access to opioid analgesics: a worldwide, regional, and national study","volume":"387","author":"Berterame S","year":"2016","unstructured":"Berterame S, Erthal J, Thomas J, Fellner S, Vosse B, Clare, et al. 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