{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:39:12Z","timestamp":1791005952265,"version":"4.1.0"},"reference-count":42,"publisher":"King Faisal Specialist Hospital and Research Centre","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Saudi Med"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The presence of nodules in the thyroid gland is common in iodine-deficient areas of the world. Recently, vitamin D levels were found to be lower than normal and sometimes deficient in malignant nodules of the thyroid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>Evaluate the relationship between the serum vitamin D levels and benign thyroid nodules in euthyroid patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN:<\/jats:title>\n                    <jats:p>Cross-sectional.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING:<\/jats:title>\n                    <jats:p>Tertiary care center in Turkey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND METHODS:<\/jats:title>\n                    <jats:p>Patients referred to the general surgery outpatient clinic and diagnosed with thyroid nodules were the study group. The control group consisted of healthy individuals without thyroid nodules. Age, BMI, thyroid ultrasonography, serum 25-hydroxyvitamin D, free T3, free T4, thyroid stimulating hormone, calcium, magnesium, phosphorous, total protein, albumin, glucose, creatinine levels and glomerular filtration rate (GFR) were compared between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN OUTCOME MEASURE:<\/jats:title>\n                    <jats:p>Serum 25-hydroxy-vitamin D levels and size of the thyroid nodules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SAMPLE SIZE AND CHARACTERISTICS:<\/jats:title>\n                    <jats:p>Of 849 individuals, 453 were patients with thyroid nodules and 396 were healthy individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The mean serum vitamin D levels of patients with thyroid nodules were significantly lower than controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;.001). Serum vitamin D levels along with serum total protein levels and eGFR were independent variables associated with the presence of a thyroid nodule (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;.001, p=.005 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =.017, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>These findings suggest vitamin D deficiency might be one of the pathophysiologic factors in development of thyroid nodules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LIMITATION:<\/jats:title>\n                    <jats:p>Single-center and possible information bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONFLICTS OF INTEREST:<\/jats:title>\n                    <jats:p>None.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5144\/0256-4947.2022.83","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T07:59:24Z","timestamp":1649145564000},"page":"83-88","source":"Crossref","is-referenced-by-count":10,"title":["Benign nodules of the thyroid gland and 25-hydroxy-vitamin D levels in euthyroid patients"],"prefix":"10.5144","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9481-7756","authenticated-orcid":true,"given":"Hac\u0131","family":"Bolat","sequence":"first","affiliation":[{"name":"From the Department of General Surgery, Faculty of Medicine, Ni\u011fde \u00d6mer Halisdemir University, Ni\u011fde, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliriza","family":"Erdo\u011fan","sequence":"additional","affiliation":[{"name":"From the Department of General Surgery, Faculty of Medicine, Ni\u011fde \u00d6mer Halisdemir University, Ni\u011fde, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3134","reference":[{"issue":"1","key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer","volume":"26","author":"Haugen BR","year":"2016","unstructured":"Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2016;26(1):1\u2013133.","journal-title":"Thyroid"},{"issue":"3","key":"e_1_3_1_3_2","first-page":"2332","article-title":"Treatment for benign thyroid nodules with a combination of natural extracts","volume":"20","author":"Stancioiu F","year":"2019","unstructured":"Stancioiu F, Mihai D, Papadakis GZ, Tsatsakis A, Spandidos DA, Badiu C. Treatment for benign thyroid nodules with a combination of natural extracts. Mol Med Rep. 2019;20(3):2332\u20138.","journal-title":"Mol Med Rep"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.11.002"},{"issue":"8","key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1056\/NEJM199302253280807","article-title":"Management of a Solitary Thyroid Nodule","volume":"328","author":"Desforges JF","year":"1993","unstructured":"Desforges JF, Mazzaferri EL. Management of a Solitary Thyroid Nodule. N Engl J Med. 1993;328(8):553\u20139.","journal-title":"N Engl J Med"},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000503575","article-title":"Review of Factors Contributing to Nodular Goiter and Thyroid Carcinoma","volume":"29","author":"Yildirim Simsir I","year":"2020","unstructured":"Yildirim Simsir I, Cetinkalp S, Kabalak T. Review of Factors Contributing to Nodular Goiter and Thyroid Carcinoma. Vol. 29, Medical Principles and Practice. S. Karger AG; 2020; 1\u20135.","journal-title":"Medical Principles and Practice"},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s40618-015-0391-7","article-title":"Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters","volume":"39","author":"Knobel M","year":"2016","unstructured":"Knobel M. Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters. Vol. 39, Journal of Endocrinological Investigation. Springer International Publishing; 2016; 357\u201373.","journal-title":"Journal of Endocrinological Investigation"},{"issue":"5","key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00108-005-1395-8","article-title":"Diagnostik und therapie des schilddr\u00fcsenknotens","volume":"46","author":"T\u00f6njes A","year":"2005","unstructured":"T\u00f6njes A, Paschke R. Diagnostik und therapie des schilddr\u00fcsenknotens. Internist. 2005 May;46(5):565\u201374.","journal-title":"Internist"},{"issue":"1","key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/10408398.2020.1714542","article-title":"Nutritional status and follicular-derived thyroid cancer: An update","volume":"61","author":"Barrea L","year":"2021","unstructured":"Barrea L, Gallo M, Ruggeri RM, Giacinto PD, Sesti F, Prinzi N, Adinolfi V, Barucca V, Renzelli V, Muscogiuri G, Colao A, Baldelli R; E.O.L.O. Group. Nutritional status and follicular-derived thyroid cancer: An update. Crit Rev Food Sci Nutr. 2021;61(1):25\u201359.","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"3","key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.7863\/ultra.33.3.495","article-title":"Real-time ultrasound elastography for differentiation of benign and malignant thyroid nodules: A meta-analysis","volume":"33","author":"Sun J","year":"2014","unstructured":"Sun J, Cai J, Wang X. Real-time ultrasound elastography for differentiation of benign and malignant thyroid nodules: A meta-analysis. J Ultrasound Med. 2014;33(3):495\u2013502.","journal-title":"J Ultrasound Med"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.01204"},{"key":"e_1_3_1_12_2","volume-title":"Lippincott'sIllustrated Reviews Series","author":"Champe PC","year":"2007","unstructured":"Champe PC, Harvey RA FD. Biochemistry. In: E. U, editor. Lippincott'sIllustrated Reviews Series. 3rd ed. Nobel Medicine Bookstores. 2007.","edition":"3"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/0256-4947.87097"},{"issue":"2","key":"e_1_3_1_14_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1478-3231.2011.02638.x","article-title":"Changes in vitamin D binding protein and vitamin D concentrations associated with liver transplantation","volume":"32","author":"Reese PP","year":"2012","unstructured":"Reese PP, Bloom RD, Feldman HI, Huverserian A, Thomasson A, Shults J, et al. Changes in vitamin D binding protein and vitamin D concentrations associated with liver transplantation. Liver Int. 2012;32(2):287\u201396.","journal-title":"Liver Int"},{"issue":"14","key":"e_1_3_1_15_2","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13143516","article-title":"The Role of Vitamin D as a Prognostic Marker in Papillary Thyroid Cancer","volume":"13","author":"Bains A","year":"2021","unstructured":"Bains A, Mur T, Wallace N, Noordzij JP. The Role of Vitamin D as a Prognostic Marker in Papillary Thyroid Cancer. Cancers (Basel). 2021;13(14).","journal-title":"Cancers (Basel)"},{"key":"e_1_3_1_16_2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.nut.2018.04.015","article-title":"Vitamin D deficiency as a risk factor for thyroid cancer: A meta-analysis of case-control studies","volume":"57","author":"Zhao J","year":"2019","unstructured":"Zhao J, Wang H, Zhang Z, Zhou X, Yao J, Zhang R, et al. Vitamin D deficiency as a risk factor for thyroid cancer: A meta-analysis of case-control studies. Nutrition. 2019;57:5\u201311.","journal-title":"Nutrition"},{"issue":"3","key":"e_1_3_1_17_2","first-page":"160","article-title":"Vitamin D deficiency as a potentially modifiable risk factor for thyroid cancer","volume":"41","author":"Roskies M","year":"2012","unstructured":"Roskies M, Dolev Y, Caglar D, Hier MP, Mlynarek A, Majdan A, et al. Vitamin D deficiency as a potentially modifiable risk factor for thyroid cancer. J Otolaryngol - Head Neck Surg. 2012;41(3):160\u20133.","journal-title":"J Otolaryngol - Head Neck Surg"},{"key":"e_1_3_1_18_2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.nut.2018.04.015","article-title":"Vitamin D deficiency as a risk factor for thyroid cancer: A meta-analysis of case-control studies","volume":"57","author":"Zhao J","year":"2019","unstructured":"Zhao J, Wang H, Zhang Z, Zhou X, Yao J, Zhang R, et al. Vitamin D deficiency as a risk factor for thyroid cancer: A meta-analysis of case-control studies. Vol. 57, Nutrition. Elsevier Inc.; 2019;5\u201311.","journal-title":"Nutrition"},{"key":"e_1_3_1_19_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/805716","article-title":"The Prevalence of Vitamin D Deficiency Is Similar between Thyroid Nodule and Thyroid Cancer Patients","volume":"2010","author":"Laney N","year":"2010","unstructured":"Laney N, Meza J, Lyden E, Erickson J, Treude K, Goldner W. The Prevalence of Vitamin D Deficiency Is Similar between Thyroid Nodule and Thyroid Cancer Patients. Int J Endocrinol. 2010;2010:1\u20137.","journal-title":"Int J Endocrinol"},{"issue":"1","key":"e_1_3_1_20_2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12902-019-0376-1","article-title":"Changes of serum 25(OH) D3 and IGF-1 levels in patients with thyroid nodules","volume":"19","author":"Du X","year":"2019","unstructured":"Du X, Liu Y, Zhao C, Fang J, Wang X, Wei L. Changes of serum 25(OH) D3 and IGF-1 levels in patients with thyroid nodules. BMC Endocr Disord. 2019 May;19(1):48.","journal-title":"BMC Endocr Disord"},{"issue":"5","key":"e_1_3_1_21_2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4103\/ijem.IJEM_526_19","article-title":"Vitamin D, Thyroid Autoimmunity and Cancer: An Interplay of Different Factors","volume":"23","author":"Dutta D","year":"2019","unstructured":"Dutta D, Sharma M, Aggarwal S, Mohindra R, Bhattacharya S, Kalra S. Vitamin D, Thyroid Autoimmunity and Cancer: An Interplay of Different Factors. Indian J Endocrinol Metab. 2019;23(5):507\u201313.","journal-title":"Indian J Endocrinol Metab"},{"issue":"7","key":"e_1_3_1_22_2","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S2213-8587(20)30183-2","article-title":"Vitamin-D and COVID-19: do deficient risk a poorer outcome?","volume":"8","author":"Mitchell F","year":"2020","unstructured":"Mitchell F. Vitamin-D and COVID-19: do deficient risk a poorer outcome? Lancet Diabetes Endocrinol. 2020;8(7):570.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"e_1_3_1_23_2","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses","volume":"41","author":"Erdfelder E","year":"2009","unstructured":"Erdfelder E, FAul F, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behav Res Methods. 2009;41:1149\u201360.","journal-title":"Behav Res Methods"},{"key":"e_1_3_1_24_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul F","year":"2007","unstructured":"Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175\u201391.","journal-title":"Behav Res Methods"},{"issue":"8","key":"e_1_3_1_25_2","first-page":"380","article-title":"Estado de vitamina D en pacientes egipcios con BMN eutiroideo y su correlaci\u00f3n con las concentraciones de TSH","volume":"63","author":"Aboelnaga MM","year":"2016","unstructured":"Aboelnaga MM, Elshafei MM, Elsayed E. Estado de vitamina D en pacientes egipcios con BMN eutiroideo y su correlaci\u00f3n con las concentraciones de TSH. Endocrinol y Nutr. 2016;63(8):380\u20136.","journal-title":"Endocrinol y Nutr"},{"issue":"5","key":"e_1_3_1_26_2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4103\/ijem.IJEM_526_19","article-title":"Vitamin D, thyroid autoimmunity and cancer: An interplay of different factors","volume":"23","author":"Dutta D","year":"2019","unstructured":"Dutta D, Sharma M, Aggarwal S, Mohindra R, Bhattacharya S, Kalra S. Vitamin D, thyroid autoimmunity and cancer: An interplay of different factors. Indian J Endocrinol Metab. 2019;23(5):507\u201313.","journal-title":"Indian J Endocrinol Metab"},{"key":"e_1_3_1_27_2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.annepidem.2007.12.002","article-title":"Vitamin D and Cancer Incidence in the Harvard Cohorts","volume":"19","author":"Giovannucci E","year":"2009","unstructured":"Giovannucci E. Vitamin D and Cancer Incidence in the Harvard Cohorts. Vol. 19, Annals of Epidemiology. Ann Epidemiol; 2009; 84\u20138.","journal-title":"Annals of Epidemiology"},{"key":"e_1_3_1_28_2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc3691","article-title":"The role of vitamin D in reducing cancer risk and progression","volume":"14","author":"Feldman D","year":"2014","unstructured":"Feldman D, Krishnan A V., Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Vol. 14, Nature Reviews Cancer. Nature Publishing Group; 2014; 342\u201357.","journal-title":"Nature Reviews Cancer"},{"key":"e_1_3_1_29_2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-pharmtox-010510-100611","article-title":"Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D","volume":"51","author":"Krishnan A V.","year":"2011","unstructured":"Krishnan A V., Feldman D. Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D. Annu Rev Pharmacol Toxicol. 2011;51:311\u201336.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.23736\/S2724-6507.20.03160-0"},{"issue":"3","key":"e_1_3_1_31_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/jcb.240490314","article-title":"1,25-Dihydroxycholecalciferol modulates 3H-Thymidine Incorporation in FRTL5 Cells","volume":"49","author":"Ongphiphadhanakul B","year":"1992","unstructured":"Ongphiphadhanakul B, Ebner SA, Fang SL, Lombardi A, Baran DT, Braverman LE. 1,25-Dihydroxycholecalciferol modulates 3H-Thymidine Incorporation in FRTL5 Cells. J Cell Biochem. 1992;49(3):304\u20139.","journal-title":"J Cell Biochem"},{"issue":"1","key":"e_1_3_1_32_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0303-7207(91)90274-V","article-title":"Cholecalciferol metabolites attenuate cAMP production in rat thyroid cells (FRTL-5)","volume":"76","author":"Berg JP","year":"1991","unstructured":"Berg JP, S\u00f8rnes G, Torjesen PA, Haug E. Cholecalciferol metabolites attenuate cAMP production in rat thyroid cells (FRTL-5). Mol Cell Endocrinol. 1991;76(1-3):201\u20136.","journal-title":"Mol Cell Endocrinol"},{"issue":"11","key":"e_1_3_1_33_2","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1089\/thy.2014.0090","article-title":"Low serum 25 hydroxyvitamin d is associated with poor clinicopathologic characteristics in female patients with papillary thyroid cancer","volume":"24","author":"Kim JR","year":"2014","unstructured":"Kim JR, Kim BH, Kim SM, Oh MY, Kim WJ, Jeon YK, et al. Low serum 25 hydroxyvitamin d is associated with poor clinicopathologic characteristics in female patients with papillary thyroid cancer. Thyroid. 2014;24(11):1618\u201324.","journal-title":"Thyroid"},{"issue":"1","key":"e_1_3_1_34_2","article-title":"Vitamin D deficiency in non-autoimmune hypothyroidism: A case-control study","volume":"20","author":"Ahi S","year":"2020","unstructured":"Ahi S, Dehdar MR, Hatami N. Vitamin D deficiency in non-autoimmune hypothyroidism: A case-control study. BMC Endocr Disord. 2020;20(1).","journal-title":"BMC Endocr Disord"},{"issue":"3","key":"e_1_3_1_35_2","first-page":"267","article-title":"Vitamin D Deficiency and Its Association with Thyroid Disease","volume":"7","author":"Mackawy AMH","year":"2013","unstructured":"Mackawy AMH, Al-Ayed BM, Al-Rashidi BM. Vitamin D Deficiency and Its Association with Thyroid Disease. Int J Health Sci (Qassim). 2013;7(3):267\u201375.","journal-title":"Int J Health Sci (Qassim)"},{"issue":"5","key":"e_1_3_1_36_2","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.20960\/nh.1719","article-title":"Serum vitamin D level and its relation to thyroid hormone, blood sugar and lipid profiles in iranian sedentary work staff","volume":"35","author":"Mansorian B","year":"2018","unstructured":"Mansorian B, Attari MMA, Vahabzadeh D, Mohebbi I. Serum vitamin D level and its relation to thyroid hormone, blood sugar and lipid profiles in iranian sedentary work staff. Nutr Hosp. 2018;35(5):1107\u201314.","journal-title":"Nutr Hosp"},{"issue":"4","key":"e_1_3_1_37_2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1210\/jcem-51-4-793","article-title":"Influence of thyroid function on the serum concentration of 1,25-dihydroxyvitamin D3","volume":"51","author":"Bouillon R","year":"1980","unstructured":"Bouillon R, Muls E, De Moor P. Influence of thyroid function on the serum concentration of 1,25-dihydroxyvitamin D3. J Clin Endocrinol Metab. 1980;51(4):793\u20137.","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"e_1_3_1_38_2","first-page":"1203","article-title":"Functional abnormalities and thyroid nodules in patients with end-stage renal disease","volume":"31","author":"Cuna V","year":"2017","unstructured":"Cuna V, Menghi V, Comai G, Cappuccilli M, Cianciolo G, Raimondi C, et al. Functional abnormalities and thyroid nodules in patients with end-stage renal disease. In Vivo. 2017;31(6):1203\u20138.","journal-title":"In Vivo"},{"issue":"1","key":"e_1_3_1_39_2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3164\/jcbn.17-69","article-title":"The relationship between vitamin D and estimated glomerular filtration rate and urine microalbumin\/creatinine ratio in Korean adults","volume":"62","author":"Kim SG","year":"2018","unstructured":"Kim SG, Kim GS, Lee JH, Moon AE, Yoon H. The relationship between vitamin D and estimated glomerular filtration rate and urine microalbumin\/creatinine ratio in Korean adults. J Clin Biochem Nutr. 2018;62(1):94\u20139.","journal-title":"J Clin Biochem Nutr"},{"issue":"2","key":"e_1_3_1_40_2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12020-017-1394-2","article-title":"Association of obesity and diabetes with thyroid nodules","volume":"60","author":"Buscemi S","year":"2018","unstructured":"Buscemi S, Massenti FM, Vasto S, Galvano F, Buscemi C, Corleo D, et al. Association of obesity and diabetes with thyroid nodules. Endocrine. 2018;60(2):339\u201347.","journal-title":"Endocrine"},{"issue":"1","key":"e_1_3_1_41_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/07435800.2019.1625056","article-title":"Thyroid Nodules in Severely Obese Patients: Frequency and Risk of Malignancy on Ultrasonography","volume":"45","author":"de Siqueira RA","year":"2020","unstructured":"de Siqueira RA, Rodrigues AP dos S, Miamae LM, Tomimori EK, Silveira EA. Thyroid Nodules in Severely Obese Patients: Frequency and Risk of Malignancy on Ultrasonography. Endocr Res. 2020;45(1):9\u201316.","journal-title":"Endocr Res"},{"issue":"2","key":"e_1_3_1_42_2","first-page":"268","article-title":"Detection rate of thyroid nodules in routine health check-up and its influencing factors: a 10-year survey of 309 576 cases","volume":"40","author":"Lai X","year":"2020","unstructured":"Lai X, Ouyang P, Zhu H, An S, Xia L, Yao Y, et al. Detection rate of thyroid nodules in routine health check-up and its influencing factors: a 10-year survey of 309 576 cases. Nan Fang Yi Ke Da Xue Xue Bao. 2020;40(2):268\u201373.","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"issue":"3","key":"e_1_3_1_43_2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.31557\/APJCP.2019.20.3.693","article-title":"Factors associated with the occurrence of thyroid nodules in severely obese patients: A case-control study","volume":"20","author":"de Siqueira RA","year":"2019","unstructured":"de Siqueira RA, Noll M, Rodrigues AP dos S, Silveira EA. Factors associated with the occurrence of thyroid nodules in severely obese patients: A case-control study. Asian Pacific J Cancer Prev. 2019;20(3):693\u20137.","journal-title":"Asian Pacific J Cancer Prev"}],"container-title":["Annals of Saudi Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T02:36:29Z","timestamp":1750300589000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.annsaudimed.net\/doi\/10.5144\/0256-4947.2022.83"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.5144\/0256-4947.2022.83"],"URL":"https:\/\/doi.org\/10.5144\/0256-4947.2022.83","relation":{},"ISSN":["0256-4947","0975-4466"],"issn-type":[{"value":"0256-4947","type":"print"},{"value":"0975-4466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}