{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:17:26Z","timestamp":1780046246496,"version":"3.53.1"},"reference-count":12,"publisher":"King Faisal Specialist Hospital and Research Centre","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Saudi Med"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Intraoperative lactate levels increase in patients undergoing craniotomy, but the reason is not yet fully known. High levels of intraoperative lactate are associated with mortality and morbidity in patients with septic shock and abdominal and cardiac surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVES:<\/jats:title>\n            <jats:p>Investigate whether intraoperative lactate elevation is associated with postoperative systemic and neurological complications and mortality in craniotomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>DESIGN:<\/jats:title>\n            <jats:p>Retrospective study<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SETTING:<\/jats:title>\n            <jats:p>University hospital in Turkey.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS AND METHODS:<\/jats:title>\n            <jats:p>In this study, we included patients who underwent elective intracranial tumor surgery in our hospital between 1 January 2018, and 31 December 2018. According to the level of intraoperative lactate, patients were divided into two groups: high (\u22652.1 mmol\/L) and normal (&lt;2.1 mmol\/L). The groups were compared by the presence of postoperative new neurological deficits, postoperative surgical and medical complications, mechanical ventilation duration, 30-day mortality, in-hospital mortality, and hospital stay length. Cox regression analysis was performed for the 30-day mortality outcome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MAIN OUTCOME MEASURES:<\/jats:title>\n            <jats:p>Association between intraoperative lactate levels and postoperative 30-day mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SAMPLE SIZE:<\/jats:title>\n            <jats:p>163 patients with lactate data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              While no significant difference was found between the groups regarding age, gender, ASA score, tumor location, operation time and pathology results, preoperative neurologic deficits were higher in the high intraoperative lactate group (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =.017). No statically significant difference was found between the groups for postoperative neurological deficit, need for prolonged mechanical ventilation, and hospital stay length. The postoperative 30-day mortality rate was higher in the group with high intraoperative lactate (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =.028). High lactate and medical complications were significant in the Cox analysis.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION:<\/jats:title>\n            <jats:p>Intraoperative lactate elevation was associated with postoperative 30-day mortality in patients undergoing craniotomy. The intraoperative level of lactate is an important mortality predictor in patients undergoing craniotomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>LIMITATIONS:<\/jats:title>\n            <jats:p>Retrospective design and single-centered, missing most data for several variables.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONFLICT OF INTEREST:<\/jats:title>\n            <jats:p>None.<\/jats:p>\n          <\/jats:sec>","DOI":"10.5144\/0256-4947.2023.166","type":"journal-article","created":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T08:05:06Z","timestamp":1685865906000},"page":"166-171","source":"Crossref","is-referenced-by-count":5,"title":["Association of intraoperative lactate elevation and postoperative mortality and morbidity in patients undergoing craniotomy: retrospective analysis"],"prefix":"10.5144","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4052-9593","authenticated-orcid":true,"given":"Seval","family":"K\u0131lbasanl\u0131","sequence":"first","affiliation":[{"name":"From the Department of Anesthesiology, Nigde Training and Research Hospital, Nigde, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat Ya\u015far","family":"\u00d6zkalkanl\u0131","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3134","reference":[{"issue":"3","key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s11060-016-2318-3","article-title":"Epidemiology for primary brain tumors: a nationwide population-based study","volume":"13","author":"Darlix A","year":"2017","unstructured":"Darlix A, Zouaoui S, Rigau V, Bessaoud F, Figarella-Branger D, Mathieu-Daud\u00e9 H, et al. 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