{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:13:54Z","timestamp":1787609634222,"version":"build-2736575974"},"reference-count":52,"publisher":"King Faisal Specialist Hospital and Research Centre","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Saudi Med"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are surgical methods used for rectal neuroendocrine tumors (NETs) with diameters of \u2264 10 mm. However, which method has a higher performance remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>Evaluate which of the two methods shows a higher performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN:<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Data from PubMed, Embase, Cochrane Library, and Web of Science were searched from inception to 12 April 2022. Outcomes, including complete resection, en bloc resection, recurrence, perforation, bleeding, and procedure time, were pooled by 95% confidence intervals (95% CI) using a fixed- or random-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN OUTCOME MEASURES:<\/jats:title>\n                    <jats:p>Complete resection, en bloc resection, and recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SAMPLE SIZE:<\/jats:title>\n                    <jats:p>18 studies, including 1168 patients were included in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Eighteen retrospective cohort studies were included in this meta-analysis. There were no statistical differences in the rates of complete resection, en bloc resection, recurrence, perforation, and bleeding rates between EMR and ESD. However, a statistical difference was detected in the procedure time; EMR had a significantly shorter time (MD=\u221217.47, 95% CI=\u221222.31 \u2013 \u221212.62,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;.00001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>EMR and ESD had similar efficacies and safety profiles in resectioning rectal NETs \u2264 10 mm. Even so, the advantages of EMR included a shorter operation time and expenditure. Thus, with respect to health economics, EMR outperformed ESD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LIMITATION:<\/jats:title>\n                    <jats:p>Most of these studies are retrospective cohort studies instead of RCTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONFLICT OF INTEREST:<\/jats:title>\n                    <jats:p>None.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5144\/0256-4947.2023.179","type":"journal-article","created":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T04:05:06Z","timestamp":1685851506000},"page":"179-195","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of endoscopic mucosal resection versus endoscopic submucosal dissection for rectal neuroendocrine tumors \u226410mm: a systematic review and meta-analysis"],"prefix":"10.5144","volume":"43","author":[{"given":"Ce","family":"Zhou","sequence":"first","affiliation":[{"name":"From the Department of Proctology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furong","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the College of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-1624","authenticated-orcid":true,"given":"Yinghua","family":"We","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3134","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"941284","DOI":"10.3389\/fpubh.2022.941284","article-title":"Chinese and Global Burdens of Gastrointestinal Cancers From 1990 to 2019","volume":"10","author":"Xie W","year":"2022","unstructured":"Xie W, Yang T, Zuo J, Ma Z, Yu W, Hu Z, et al. 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