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The outcome included studies reporting visual analog scale scores, the Western Ontario and McMaster Universities Osteoarthritis Index, Whole-Organ Magnetic Resonance Imaging Scores, International Knee Documentation Committee scores, and the Knee injury and Osteoarthritis Outcome Score. A total of 28 meta-analyses with 32 763 participants. MSCs and PRP therapies were significantly associated with an improvement in KOA scores. This umbrella meta-analysis supports the beneficial health effects of MSCs and PRP in KOA.<\/jats:p>","DOI":"10.5144\/0256-4947.2024.195","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T02:14:09Z","timestamp":1717985649000},"page":"195-211","source":"Crossref","is-referenced-by-count":6,"title":["Mesenchymal stem cells and platelet rich plasma therapy for knee osteoarthritis: an umbrella review of systematic reviews with meta-analysis"],"prefix":"10.5144","volume":"44","author":[{"given":"Feng","family":"Lin","sequence":"first","affiliation":[{"name":"From the Department of Joint Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Department of Joint Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4309-9161","authenticated-orcid":false,"given":"Cunbao","family":"Cui","sequence":"additional","affiliation":[{"name":"From the Department of Joint Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3134","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/2191926","article-title":"Efficacy and safety of intraarticular platelet-rich plasma in osteoarthritis knee: a systematic review and meta-analysis","volume":"2021","author":"Hong M","year":"2021","unstructured":"Hong M, Cheng C, Sun X, Yan Y, Zhang Q, Wang W, et al. 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